• Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics

Welcome to the Garcia Lab

“Spectrometry for the Masses”

The Garcia Lab utilizes high-resolution mass spectrometry to explore cellular signaling, epigenetic mechanisms and chromatin regulation.  We are especially interested in understanding how protein and nucleic acid modifications mediate their canonical functions and regulate nuclear processes. Mass spectrometry has become an unparalleled tool in the analysis of these biological molecules and allows us to obtain quantitative information about modifications as well as their co-occurrence. These modifications are critical for nuclear stability and transcription; and dysregulation of these pathways underlie several human diseases such as cancer.  Our work aims to reveal the roles of these modifications in the cell cycle, proliferation, differentiation, signaling pathways and metabolism, to consequently help elucidate the mechanisms of various diseases. The Garcia Lab is part of the Epigenetics Institute and Department of Biochemistry and Molecular Biophysics here at the University of Pennsylvania School of Medicine.

February 2018

Kelly Karch will become the first Garcia Lab UPenn student to defend her PhD thesis. Don’t miss it, Tuesday Feb. 20th, JMEC Law Auditorium at 1 pm!

Mariel C’s collaboration with the Berger and Capell labs here at UPenn on MLL4 regulation of epithelial progenitor gene expression is published (http://genesdev.cshlp.org/content/early/2018/02/12/gad.306241.117.full.pdf+html), congrats!

January 2018

Laura Romano (PGG) joins us for the winter rotation, welcome!

Our collaboration with the Klein lab “Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing” has been selected as the representative ‘Genomics and proteomics’ article for the 2017 retrospective collection called “The year in JBC: 2017”. Read about it here.

The Garcia Lab says goodbye to Sara on her new industrial position, best of luck!