• Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics

Welcome to the Garcia Lab

“Spectrometry for the Masses”

The Garcia Lab utilizes high-resolution mass spectrometry to explore cellular signaling, epigenetic mechanisms and chromatin regulation.  We are especially interested in understanding how protein and nucleic acid modifications mediate their canonical functions and regulate nuclear processes. Mass spectrometry has become an unparalleled tool in the analysis of these biological molecules and allows us to obtain quantitative information about modifications as well as their co-occurrence. These modifications are critical for nuclear stability and transcription; and dysregulation of these pathways underlie several human diseases such as cancer.  Our work aims to reveal the roles of these modifications in the cell cycle, proliferation, differentiation, signaling pathways and metabolism, to consequently help elucidate the mechanisms of various diseases. The Garcia Lab is part of the Epigenetics Institute and Department of Biochemistry and Biophysics here at the University of Pennsylvania School of Medicine.

March 2019

John’s work on the epigenetic mechanisms in MPNST cancers is published in Cancer Research, congrats!

Yekaterina gave a talk, and our former summer HS student Bella presented a poster at the Pittcon Conference in Philadelphia, PA.

Collaborations with the Maze lab (Mt. Sinai) on a new histone modification sertonylation, and with the Jabado lab (McGill University) to further understand how the H3K27M mutation affects H3K27 methylation spreading are published in Nature and Nature Communications, respectively. Additionally,  Bhanu’s work describing signaling cross-talk with a trans-histone code during myogenesis is published in the Journal of Biological Chemistry, congrats.

The Garcia Lab is the featured lab of the month on the Epigenetics Institute website, check out the video here, and the Garcia Lab blog post here.

The Garcia Lab will have 4 talks (Josue, Zuo-Fei, Amber and Mariel C), and 12 posters at the ASMS Conference later this year, watch out Atlanta!

The Garcia Lab returns from the US HUPO Conference in Rockville, MD. Mariel C., Peder and Richard gave short talks; Khadija, Zuo-Fei, Kasia and Congcong gave lightning talks; Yekaterina gave a Tips & Tricks talk and Ben gave an invited talk. We also had poster presentations from Josue, Yekaterina, Jen, Khadija, Joe, Kasia, Abby, Bhanu, Zuo-Fei, Congcong and Super M. Last but not least, Yekaterina also won first place in the graduate student poster competition!

Richard’s collaboration with the Bonasio and Davidovich labs to map RNA-protein binding sites on the EZH2 complex that influence its activity is published in Nat Struct Mol Biol.

Mariel C. has been selected to attend the Lindau Nobel Laureate meeting in Germany, congrats!

Sam successfully defends his PhD thesis, congratulations Dr. Wein!

The Garcia Lab says goodbye to Simone, who is off to start his independent faculty position at the Einstein College of Medicine, you’ll be missed, best of luck!

February 2019

Abby has been selected to receive an Undergraduate Student travel award from the American Society for Mass Spectrometry (ASMS) to attend the annual ASMS conference in June, congratulations!

Former graduate student Kelly Karch has received a President’s Postdoctoral Scholars Fellowship from the Ohio State University to join Vicki Wysocki’s lab for her postdoctoral studies, congrats!

Mariel C. has been awarded a Graduate Student travel award from the American Society for Mass Spectrometry (ASMS) to attend the annual ASMS conference in June, congrats!

Amber has been selected to receive an AACR-Margaret Foti Scholar-in-Training award from the American Association for Cancer Research, congrats!

A collaborative study with the Berger lab (UPenn) on the role of p300 in senescence is published in Molecular Cell.

Congcong’s multi-omics study to interrogate signaling pathway crosstalk and epigenetic mechanisms during the epithelial to mesenchymal transition in cancer is published in Epigenetics and Chromatin.

Peder has been awarded a travel award to attend the US-HUPO conference next month.

Simone publishes a methods article on understanding the role of acetyl-CoA metabolism and histone modifications.

Peder has received a Chrohn’s and Colitis Foundation Postdoctoral Fellowship, congratulations!

Josue is awarded an American Society for Mass Spectrometry Postdoctoral Career Development Award, congrats!

The Garcia Lab says goodbye to Anumita, who will be starting her new position at Merck, good luck!