• Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics

Welcome to the Garcia Lab

“Spectrometry for the Masses”

The Garcia Lab utilizes high-resolution mass spectrometry to explore cellular signaling, epigenetic mechanisms and chromatin regulation.  We are especially interested in understanding how protein and nucleic acid modifications mediate their canonical functions and regulate nuclear processes. Mass spectrometry has become an unparalleled tool in the analysis of these biological molecules and allows us to obtain quantitative information about modifications as well as their co-occurrence. These modifications are critical for nuclear stability and transcription; and dysregulation of these pathways underlie several human diseases such as cancer.  Our work aims to reveal the roles of these modifications in the cell cycle, proliferation, differentiation, signaling pathways and metabolism, to consequently help elucidate the mechanisms of various diseases. The Garcia Lab is part of the Epigenetics Institute and Department of Biochemistry and Molecular Biophysics here at the University of Pennsylvania School of Medicine.

October 2017

Kelly’s research on histone ADP-ribosylation is published in Molecular BioSystems, congrats!

The Garcia Lab comes back from the Epigenetics Institute Retreat at Citizens Bank Park (home of the Philadelphia Phillies). Mariel gave a talk, and Kasia, Simone, Peder and Laura presented posters.

The Garcia Lab welcomes new postdoc Geoff Dann to the group.

Collaborations with the Bonasio lab (UPenn) on methods to determine RNA-binding protein domains, with the Weitzman lab to identify proteomes on viral genomes, and with the Berger lab on the role of cytoplasmic chromatin in senescence are published in JoVEMolecular and Cellular Proteomics, and Nature, respectively.

 

September 2017

Collaborations with the Klein lab (UPenn), Eckenhoff lab (UPenn) and Lazar lab (UPenn) focusing on the GSK-3 phosphoproteome,  identification of drug-binding sites on the transient receptor potential ankyrin 1 ion channel,  and the HDAC3 interactome are published in JBC, the Biophysical Journal and Nature Communications, respectively.

The Garcia Lab comes back from a GRAAM (Garcia-Roeder-Allis-Armstrong-Muir) meeting at Rockefeller University where John presented his latest research.

Laura and Kevin present their research progress at the department Friday Research Discussion.

The Garcia Lab wishes Yanping well in her new position at Johnson & Johnson.

The Garcia Lab welcomes a new Research Specialist Joseph Cesare to the Quantitative Proteomics Resource Core.

PGG graduate student Khadija Wilson joins the group for the Fall rotation, welcome!