• Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics

Welcome to the Garcia Lab

“Spectrometry for the Masses”

The Garcia Lab utilizes high-resolution mass spectrometry to explore cellular signaling, epigenetic mechanisms and chromatin regulation.  We are especially interested in understanding how protein and nucleic acid modifications mediate their canonical functions and regulate nuclear processes. Mass spectrometry has become an unparalleled tool in the analysis of these biological molecules and allows us to obtain quantitative information about modifications as well as their co-occurrence. These modifications are critical for nuclear stability and transcription; and dysregulation of these pathways underlie several human diseases such as cancer.  Our work aims to reveal the roles of these modifications in the cell cycle, proliferation, differentiation, signaling pathways and metabolism, to consequently help elucidate the mechanisms of various diseases. The Garcia Lab is part of the Epigenetics Institute and Department of Biochemistry and Biophysics here at the University of Pennsylvania School of Medicine.

January 2019

The Garcia Lab welcomes our new BMB rotation students Kollin Schultz and Michael Gilbert to the group.

Collaborative studies with the Zaret lab (UPenn) on the role of heterochromatin during lineage commitment, and with the Wellen lab (UPenn) on the role of acetyl-CoA metabolism in pancreatic cancer are published in Science, and Cancer Discovery, respectively.

December 2018

Hee Jong has has been awarded an NIH Chemistry-Biology Interface graduate training fellowship, well done!

A collaborative manuscript with the Pierce lab (UPenn) to understand epigenetic mechanisms behind transgenerational cocaine addiction and behavioral consequences is published in the European Journal of Neuroscience.

The Garcia Lab says goodbye to Ranran, who will be starting a new position at MD Anderson in Houston, best of luck!

The Garcia Lab had the annual Holiday Party with food, games and a gift exchange. Bhanu won the best “ugliest” sweater contest, although there were several top contenders.

The Garcia Lab participates in the Chemistry-Biology Interface Symposium. Simone gave a talk, and several members gave posters including Joe who won second place for his poster presentation.

Dylan and John’s review on cancer epigenetics is published in Expert Review in Proteomics.

Stephanie is awarded a Michael S. Brown Penn-GSK Postdoctoral Fellowship, congrats!