• Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics

Welcome to the Garcia Lab

“Spectrometry for the Masses”

The Garcia Lab utilizes high-resolution mass spectrometry to explore cellular signaling, epigenetic mechanisms and chromatin regulation.  We are especially interested in understanding how protein and nucleic acid modifications mediate their canonical functions and regulate nuclear processes. Mass spectrometry has become an unparalleled tool in the analysis of these biological molecules and allows us to obtain quantitative information about modifications as well as their co-occurrence. These modifications are critical for nuclear stability and transcription; and dysregulation of these pathways underlie several human diseases such as cancer.  Our work aims to reveal the roles of these modifications in the cell cycle, proliferation, differentiation, signaling pathways and metabolism, to consequently help elucidate the mechanisms of various diseases. The Garcia Lab is part of the Epigenetics Institute and Department of Biochemistry and Molecular Biophysics here at the University of Pennsylvania School of Medicine.

October 2018

The Garcia Lab welcomes our new postdoc Stephanie Miller Lehman to Philly.

Ben is interviewed by The Analytical Scientist, read here.

Kelly’s manuscript describing  Top and Middle Down Hydrogen-Deuterium exchange MS approaches for probing nucleosomal conformation is published in Structure.

Ben is interviewed in a Panel Discussion on the past, present and future of quantitative proteomics for the ProteomicsNOW MS Virtual Event (www.proteomicsnow.com) sponsored by Thermo Fisher Scientific and Wiley Publishing.

Our collaboration with the Greenberg Lab describing the effect of phosphorylation on TIP60 during DNA damage is published in Molecular and Cellular Biology.

The Garcia Lab returns from a great experience at the HUPO 2018 conference in Orlando, FL. We had multiple poster presentations from the lab (Kasia, Jen, Josue, John, Dylan, Kevin, Mariel M, Amber, Joe, Yekaterina, Bhanu, Peder and Geoff). Amber was also chosen as one of 8 Finalists for the PhD Poster Competition, where she gave a 3 min short talk on her work. Later she was selected as one of the 3 winners of the competition!  Laura, Mariel and Ben gave talks, and Yekaterina won a travel award. Overall, it was a fantastic conference and fun time.

September 2018

Collaboration with the Locasale lab (Duke) to understand acetate production from glucose is published in Cell.

Congratulations to Simone, who has accepted an offer to start his own lab at the Albert Einstein College of Medicine!

Our collaborative work with the Strome lab (UC Santa Cruz) to understand epigenetic memory and transmission of histone H3K36 methylation is published in Genetics.

Mariel M has been awarded an NIH Diversity Supplement grant award from the National Cancer Institute, congrats!

The Garcia lab welcomes Janice Reynaga and Neha Srikumar (both BMB graduate students) to the lab for the fall rotation.