• Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics

Welcome to the Garcia Lab

“Spectrometry for the Masses”

The Garcia Lab utilizes high-resolution mass spectrometry to explore cellular signaling, epigenetic mechanisms and chromatin regulation.  We are especially interested in understanding how protein and nucleic acid modifications mediate their canonical functions and regulate nuclear processes. Mass spectrometry has become an unparalleled tool in the analysis of these biological molecules and allows us to obtain quantitative information about modifications as well as their co-occurrence. These modifications are critical for nuclear stability and transcription; and dysregulation of these pathways underlie several human diseases such as cancer.  Our work aims to reveal the roles of these modifications in the cell cycle, proliferation, differentiation, signaling pathways and metabolism, to consequently help elucidate the mechanisms of various diseases. The Garcia Lab is part of the Epigenetics Institute and Department of Biochemistry and Molecular Biophysics here at the University of Pennsylvania School of Medicine.

August 2018

The Garcia Lab has a fun time at the Department of Biochemistry and Biophysics picnic. Kevin, Laura, Simone, Bella, Alina and Ben even help the department team (“RNAces”) beat the Physiology department in the big softball game 4-3 (Bella even knocked in the winning run!).

Amber has been named a finalist for the PhD Poster Competition at next month’s World HUPO Congress. She will give a short presentation and compete against 7 other finalists, read here. Good luck!

The Garcia Lab says goodbye to Dr. Kelly Karch, who will travel the world before moving onto a postdoc position.

The Garcia Lab also says goodbye to our summer undergrad and HS researchers: Emily, Maura, Bella, Ayushi and Nia. Thanks for all the hard work!

Visiting graduate student Minghui Chen finishes her studies in the Garcia Lab, good luck in the future!

Collaborative papers with Gerd Blobel (CHOP) and Jenny Brodbelt (UT Austin) are published in Science and the Journal of Proteome Research, respectively.

July 2018

The Garcia Lab has their annual Summer Lab Party. It was a really good time, lots of food (histone salad and nucleosome cake) and sports activities. Congratulations to Kevin and Simone (“Kev-mone”) for overcoming their differences and coming together to win the Wii Boxing Tournament!

Mariel C presented a poster on her work at the first annual Office of Research and Diversity Training Research Symposium here on campus.

Amber’s NIH F31 NRSA Predoctoral Fellowship is funded by the National Cancer Institute, congratulations!

Excited to announce that John Wojcik has officially started as an Assistant Professor in the Department of Pathology and Laboratory Medicine here at the University of Pennsylvania School of Medicine. Congratulations John, and looking forward to big things in the future from your new lab!

Ben and Donita Brady (Cancer Biology) are interviewed to discuss the Presidential Professorship and diversity in science by UPenn’s Office of Inclusion and Diversity (OID). This interview was included in the OID Annual Report (Page 7) which can be read here.

Hendrik Weisser from STORM Therapeutics visits the Garcia Lab and gives a seminar on the latest in RNA modifications analysis for therapeutic use.

Khadija has been awarded an NIH Pharmacology T32 graduate training fellowship, congrats!

Ben has been featured on the American Chemical Society (ACS) Scholars Alumni Profile Series, read here.