• Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics

Welcome to the Garcia Lab

“Spectrometry for the Masses”

The Garcia Lab utilizes high-resolution mass spectrometry to explore cellular signaling, epigenetic mechanisms and chromatin regulation.  We are especially interested in understanding how protein and nucleic acid modifications mediate their canonical functions and regulate nuclear processes. Mass spectrometry has become an unparalleled tool in the analysis of these biological molecules and allows us to obtain quantitative information about modifications as well as their co-occurrence. These modifications are critical for nuclear stability and transcription; and dysregulation of these pathways underlie several human diseases such as cancer.  Our work aims to reveal the roles of these modifications in the cell cycle, proliferation, differentiation, signaling pathways and metabolism, to consequently help elucidate the mechanisms of various diseases. The Garcia Lab is part of the Epigenetics Institute and Department of Biochemistry and Molecular Biophysics here at the University of Pennsylvania School of Medicine.

May 2018

The Garcia Lab hosts the First Annual BMB 500 racing competition for the BMB graduate program. Mariel M and Mariel C finished 8th and 4th, respectively. Nice job!

Lucy graduates from Penn, congrats! Next stop some traveling and then onto medical school.

Richard receives a travel award from the Delaware Valley MS Discussion Group to attend the upcoming ASMS conference where he will be presenting a poster, congrats!

Geoff receives a Damon Runyon Postdoctoral Fellowship, congrats!

April 2018

Ben Garcia will receive the Biemann Medal at this year’s American Society for Mass Spectrometry Conference. Read more about it here.

Our second year students, Mariel M, Yekaterina and Richard all pass their 2nd year prelim examinations, congrats!

Alina Garcia works in the lab for “Bring your child to work day”.

Graduate student Heejong Kim joins the Garcia Lab (joint student with the Murakami lab), welcome!

Anumita gives a talk at GSK during the Michael Brown Postdoctoral Program Symposium.

Peder’s collaboration with the Wu lab (UPenn) to investigate aerobic and anaerobic mechanisms in the gut microbiome are published in PNAS. Additionally, Kasia’s collaboration with the Witze lab (UPenn) on Wnt signaling promotion of melanoma is published in Elife, and a collaboration with th4e Reinberg lab (NYU) on PRC2 activity is published in Molecular Cell.