• Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics

Welcome to the Garcia Lab

“Spectrometry for the Masses”

The Garcia Lab utilizes high-resolution mass spectrometry to explore cellular signaling, epigenetic mechanisms and chromatin regulation.  We are especially interested in understanding how protein and nucleic acid modifications mediate their canonical functions and regulate nuclear processes. Mass spectrometry has become an unparalleled tool in the analysis of these biological molecules and allows us to obtain quantitative information about modifications as well as their co-occurrence. These modifications are critical for nuclear stability and transcription; and dysregulation of these pathways underlie several human diseases such as cancer.  Our work aims to reveal the roles of these modifications in the cell cycle, proliferation, differentiation, signaling pathways and metabolism, to consequently help elucidate the mechanisms of various diseases. The Garcia Lab is part of the Epigenetics Institute and Department of Biochemistry and Molecular Biophysics here at the University of Pennsylvania School of Medicine.

December 2018

Dylan and John’s review on cancer epigenetics is published in Expert Review in Proteomics.

Stephanie is awarded a Michael S. Brown Penn-GSK Postdoctoral Fellowship, congrats!

November 2018

Ben returns from BGS graduate student recruiting at the ABRCMS conference in Indianapolis. Former Garcia Lab summer student Nia Harmon gave an excellent talk.

The Garcia Lab returns from the Department/BMB graduate program retreat at the Poconos Mountains. We had several poster presentations (Josue, Yekaterina, Sam, Kevin, Richard, Mariel C, Mariel M, Dylan and Laura). Mariel C won second place in the poster competition and Ben defended his “Student Outreach” award title.

Anumita, Geoff and Jen present at the annual Biomedical Postdoctoral Research Symposium on campus, nice work!

Collaborations with the Kashina lab (UPenn) on the human arginylome, and with the Berger lab on histone modifications changes in clinically abnormal sperm are published in Scientific Reports, and the Journal of Assisted Reproduction and Genetics, respectively.

The Garcia Lab says goodbye to Mariana Lopes, our visiting graduate student who will be going back to Brazil to finish her PhD studies.

Ben is named the John McCrea Dickson M.D. Presidential Professor.