• Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics

Welcome to the Garcia Lab

“Spectrometry for the Masses”

The Garcia Lab utilizes high-resolution mass spectrometry to explore cellular signaling, epigenetic mechanisms and chromatin regulation.  We are especially interested in understanding how protein and nucleic acid modifications mediate their canonical functions and regulate nuclear processes. Mass spectrometry has become an unparalleled tool in the analysis of these biological molecules and allows us to obtain quantitative information about modifications as well as their co-occurrence. These modifications are critical for nuclear stability and transcription; and dysregulation of these pathways underlie several human diseases such as cancer.  Our work aims to reveal the roles of these modifications in the cell cycle, proliferation, differentiation, signaling pathways and metabolism, to consequently help elucidate the mechanisms of various diseases. The Garcia Lab is part of the Epigenetics Institute and Department of Biochemistry and Molecular Biophysics here at the University of Pennsylvania School of Medicine.

December 2017

Ben is named to the Advisory Committee in the Division of Biological Sciences for the National Science Foundation (NSF).

Ben gives a short research talk at the Eastern PA section of the Leukemia and Lymphoma Society.

November 2017

A multi-Penn lab collaborative effort linking TDP-43 to chromatin remodeling complexes important for induction of protective disease gene expression in amyotrophic lateral sclerosis and frontotemporal dementia is published in Current Biology.

Bernard Delanghe from Thermo (creator of the Proteome Discoverer software) visits the Garcia Lab and gives a workshop on the capabilities of the latest software version.

The Garcia Lab returns from the Department/BMB graduate group retreat in the Poconos Mountains. Joe, Simone, Kasia, Yekaterina, Dylan, Kevin, Abby, Laura, Zuo-Fei, Mariel C, Amber and Sam presented posters, and Kelly gave a great talk. Additionally, Mariel C won 2nd Place for her poster in the Biophysics category, congrats!

Congratulations to Qi, as her manuscript “Assessment of quantification precision of histone post-translational modifications by using an ion trap and down to 50,000 cells as starting material” is published in the Journal of Proteome Research.

Peder gives a talk at the Penn/CHOP Microbiome Program Symposium.

Amber’s manuscript “GiaPronto: a one-click graph visualization software for proteomics datasets” is accepted by Molecular and Cellular Proteomics, and is picked up by the Proteomics news blogspot, congrats! GiaPronto can be accessed here.

Visiting graduate student Mariana Lopes (Instituto Butantan, Brazil) joins the lab, welcome!

A collaboration with the Gorbunova lab (Univ. of Rochester) on the naked mole rat epigenome (implications for cancer resistance and longevity ) is published in Stem Cell Reports., while another collaborative study with the Sykes lab (Fox Chase Cancer Center) describing the role of the kinase PKCε in supporting cell survival and disease progression in acute myeloid leukemia is published in Clinical Cancer Research.