Publications

Isotopic Labeling and Quantitative Proteomics of Acetylation on Histones and Beyond

Isotopic Labeling and Quantitative Proteomics of Acetylation on Histones and Beyond. Lund PJ, Kori Y, Zhao X, Sidoli S, Yuan ZF, Garcia BA. Methods Mol Biol. 2019;1977:43-70.

Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription

Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription. Behera V, Stonestrom AJ, Hamagami N, Hsiung CC, Keller CA, Giardine B, Sidoli S, Yuan ZF, Bhanu NV, Werner MT, Wang H, Garcia BA, Hardison RC, Blobel GA. Cell Rep. 2019 Apr 9;27(2):400-415.e5. doi: 10.1016/j.celrep.2019.03.057.

The long noncoding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration

The long noncoding RNA Falcor regulates Foxa2 expression to maintain lung epithelial homeostasis and promote regeneration. Swarr DT, Herriges M, Li S, Morley M, Fernandes S, Sridharan A, Zhou S, Garcia BA, Stewart K, Morrisey EE. Genes Dev. 2019 Mar 28. doi: 10.1101/gad.320523.118. [Epub ahead of print]

Target identification reveals lanosterol synthase as a vulnerability in glioma

Target identification reveals lanosterol synthase as a vulnerability in glioma. Phillips RE, Yang Y, Smith RC, Thompson BM, Yamasaki T, Soto-Feliciano YM, Funato K, Liang Y, Garcia-Bermudez J, Wang X, Garcia BA, Yamasaki K, McDonald JG, Birsoy K, Tabar V, Allis CD. Proc Natl Acad Sci U S A. 2019 Mar 28. pii: 201820989. doi: 10.1073/pnas.1820989116. [Epub ahead of print]

Epigenomic reordering induced by Polycomb loss drives oncogenesis but leads to therapeutic vulnerabilities in malignant peripheral nerve sheath tumors

Epigenomic reordering induced by Polycomb loss drives oncogenesis but leads to therapeutic vulnerabilities in malignant peripheral nerve sheath tumors. Wojcik JB, Marchione DM, Sidoli S, Djedid A, Lisby A, Majewski J, Garcia BA. Cancer Res. 2019 Mar 21. pii: canres.3704.2018. doi: 10.1158/0008-5472.CAN-18-3704. [Epub ahead of print]

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis. Harutyunyan AS, Krug B, Chen H, Papillon-Cavanagh S, Zeinieh M, De Jay N, Deshmukh S, Chen CCL, Belle J, Mikael LG, Marchione DM, Li R, Nikbakht H, Hu B, Cagnone G, Cheung WA, Mohammadnia A, Bechet D, Faury D, McConechy MK, Pathania M, Jain SU, Ellezam B, Weil AG, Montpetit A, Salomoni P, Pastinen T, Lu C, Lewis PW, Garcia BA, Kleinman CL, Jabado N, Majewski J. Nat Commun. 2019 Mar 19;10(1):1262.

Regulation of proline-directed kinases and the trans-histone code H3K9me3/H4K20me3 during human myogenesis

Regulation of proline-directed kinases and the trans-histone code H3K9me3/H4K20me3 during human myogenesis. Bhanu NV, Sidoli S, Yuan ZF, Molden RC, Garcia BA. J Biol Chem. 2019 Mar 14. pii: jbc.RA118.004977. doi: 10.1074/jbc.RA118.004977. [Epub ahead of print]

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3. Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H 3rd, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I. Nature. 2019, 67(7749):535-539.

RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2

RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2. Zhang Q, McKenzie NJ, Warneford-Thomson R, Gail EH, Flanigan SF, Owen BM, Lauman R, Levina V, Garcia BA, Schittenhelm RB, Bonasio R, Davidovich C. Nat Struct Mol Biol. 2019 Mar;26(3):237-247.

Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence

Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL. Mol Cell. 2019 Feb 21;73(4):684-698.