Mechanobiology of the Heart
Our lab studies mechanotransduction in the heart, the process of converting mechanical forces to intracellular signals.
Image: The artists at Science Signaling graphically summed up our research focus!
Measuring Force in Single Heart Cells
We have developed and patented techniques to attach muscle cells (green, below) to mechanical apparatus using a novel biological adhesive called MyoTak (red). Using this system we can precisely record and control force and length in single cardiomyocytes to mimic the changes in mechanical stress heart cells experience in vivo. Image is a 3D reconstruction of confocal Z-stacks through a heart cell attached to MyoTak coated glass rods.
Item A: Webinar on measuring force in heart cells given by Dr. Prosser
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