Roles of Cardiac MyBP-C
In this work we describe a novel function for the cardiac regulatory protein MyBP-C, whose role has remained elusive. We propose that MyBP-C (red), which localizes to the sarcomere distant to the sites of calcium release (green), increases the calcium sensitivity of the contractile apparatus at this distant site in order to offset any non-uniformity in the calcium dependent activation of the sarcomere.
Image: Image acquired using STORM super-resolution imaging.
Super-Resolution View of Cardiac Microtubules
Current work in the lab is focused on the microtubule cytoskeleton and how it regulates the mechanobiology of heart cells. We are using novel techniques to manipulate and measure cell stress while using advanced imaging to examine how these stresses influence intracellular processes.
Image: STED super-resolution microscopy reveals intricate details of microtubule networks in the heart.