The Epigenetics of Reproduction group is interested in understanding the epigenetic mechanisms that govern gametogenesis and thus their potential implications for fertility and transgenerational inheritance. Multiple model systems are utilized, including yeast sporulation and mouse spermatogenesis, to investigate the role of histone post -translational modifications (PTMs) and their associated in chromatin packaging and parental transmission of the epigenome to subsequent generations of offspring. The group is particularly interested in linking histone PTMs during gamete formation to physiological function and routinely performs a diverse set of experimental techniques that focus on both molecular and function al studies. The group also collaborates with clinicians to translate basic findings in the yeast and mouse with human samples.

Lab Members
Post-Baccalaureate Scholar (PennPREP)
Research Associate