Understanding and Exploiting the Heterogeneity of Cell Intrinsic and Extrinsic Responses to DNA Damage in BRCA Mutant Cancer Cells
V Foundation Convergence Team Science Award
Susan Domchek, Ronny Drapkin, Andy Minn, and Junwei Shi


Congrats to Roger Greenberg, Ph.D., MD, for being promoted to full professor
Since joining the faculty at Penn in 2007, Roger’s scientific trajectory has been spectacular. He has established an extremely robust and productive research program focused on understanding how chromatin responses to DNA damage impact genome integrity, cancer susceptibility, and response to anti-cancer therapy. His laboratory’s work has led to the identification of several new breast cancer susceptibility genes, a human syndrome associated with biallelic BRCA1 mutations, and insights into mechanisms by which chromatin responses affect response to targeted therapies. His seminal discoveries on the molecular basis for BRCA1 recognition of DNA double strand breaks led to a flood of subsequent important additional discoveries, as well as the development of the first system to simultaneously visualize local DNA repair and transcriptional events in real time. Through these and other advances, Roger has established himself as an international leader in this area through a series of highly impactful publications in the most select peer-reviewed journals. In recognition of his scientific accomplishments, Roger has been awarded (among others) the 2010 Michael S. Brown New Investigator Award for Basic Research, the Sidney Kimmel Foundation Scholar Award, the Charles E. Culpeper Scholar Award in Medical Science, the Mary Kay Ash Foundation Award in Innovative/Translational Cancer Research, and the Harrington Scholar Innovator Award. Equally important, Roger has been an exemplary citizen within the Department of Cancer Biology, the AFCRI, and the Penn community.

Previous Next
Test Caption
Test Description goes like this