Highly Mutated Protein in Skin Cancer Plays Central Role in Skin Cell Renewal
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Brian Capell, M.D., Ph.D. received the 2018 Young Investigator Award from the American Academy of Dermatology, for his project ‘How Disrupted Epigenetics Drives Carcinogenesis.’
Congrats to Roger Greenberg, M.D, Ph.D. for his election to the National Academy of Physicians.
“Icebreaker” Protein Opens Genome for T cell Development, Penn Researchers Find
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New genomic analyses indicate that pioneer transcription factors can sample a diverse repertoire of common binding sites among different cell types and become enriched where they cooperate with other factors specific to each cell. Pioneer-factor binding is mechanistically separate from, and is necessary for, subsequent phenomena of chromatin opening and epigenetic memory in vivo.
Understanding and Exploiting the Heterogeneity of Cell Intrinsic and Extrinsic Responses to DNA Damage in BRCA Mutant Cancer Cells
V Foundation Convergence Team Science Award
Susan Domchek, Ronny Drapkin, Andy Minn, and Junwei Shi
Penn Study on Super-silenced DNA Hints at New Ways to Reprogram Cells
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Calling him “an outstanding, pioneering investigator,” the National Heart, Lung, and Blood Institute has honored Jonathan Epstein of the Perelman School of Medicine with an Outstanding Investigator Award. The prize will support his research to uncover how a fertilized egg gives rise to a diversity of specialized tissues in the body.
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Awarded a Pilot and Feasibility Grant from the NIH P30-funded Penn Skin Biology and Disease Resource-based Center (SBDRC), “Understanding the role of KMT2D and KMT2C in epithelial differentiation and carcinogenesis”.
Mia Levine awarded the NIGMS Maximizing Investigators’ Research Award (MIRA) (R35), “Causes and functional consequences of chromatin evolution.”