New genomic analyses indicate that pioneer transcription factors can sample a diverse repertoire of common binding sites among different cell types and become enriched where they cooperate with other factors specific to each cell. Pioneer-factor binding is mechanistically separate from, and is necessary for, subsequent phenomena of chromatin opening and epigenetic memory in vivo.
Research led by Rajan Jain and Jonathan Epstein of the Perelman School of Medicine suggests that the three-dimensional organization of DNA in the nucleus determines a cell’s ultimate destiny.
PIK professors Michael Platt and Shelley Berger are embarking on a joint research project focused on how stress affects the brain and behavior.
They discussed their burgeoning collaboration with Knowledge@Warton.