Junwei Shi, Ph.D.
University of Pennsylvania
The Perelman School of Medicine
Department of Cancer Biology
620 BRB II/III
421 Curie Blvd
Philadelphia , 19104
Contributions to Science
- Identifying Epigenetic Dependencies in Leukemia.
- CRISPR-based Genetic Screening Methods
- Identifying Transcriptional, Epi-transcriptional and Kinase Dependencies in Leukemia.
- Investigating Genetic Regulatory Pathways using CRISPR-based Screening Methods.
The physiological effects of cancer are a manifestation of the genetic abnormalities that cause the disease. While much progress has been made in the understanding of such genetic perturbations, scientists still struggle to effectively identify, understand, and treat cancer-causing mutations. This is due to the fast-paced evolution of the disease, and the accumulation of novel mutations that permit cell survival even in the harsh environment created by a therapeutic. CRISPR is a gene-editing technology that couples the elegance of base complementarity with the enzymatic activity of a DNA nuclease in order to introduce mutations into target loci. CRISPR technologies help advance our understanding of the genetic perturbations that contribute to cancer maintenance.
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