Kenneth S. Zaret, Ph.D.
The Perelman School of Medicine at the University of Pennsylvania
Department of Cell and Developmental Biology
9-131 Smilow Center for Translational Research
3400 Civic Center Blvd
Philadelphia, PA 19104-6059
Office: 215-573-5813
Research Interest
Ken’s laboratory discovered “pioneer factors” that bind to silent chromatin, endow the competence for cell differentiation, and promote cellular reprogramming. Recently, his lab found broad chromatin domains that can resist pioneer factor binding and serve as impediments to cellular reprogramming; these domains appear to help commit cells to particular fates. Finally, his lab has unveiled how inductive signaling in the embryo leads to chromatin modifications that affect cell fate choices, thereby identifying specific enzymatic targets for small molecules to modulate cell fate control.
Lab Members
| FIRST NAME | LAST NAME | TITLE | |
|---|---|---|---|
| Kenneth | Zaret | PI | zaret@pennmedicine.upenn.edu |
| Jonathan | Lerner | Postdoctoral Fellow | jler@pennmedicine.upenn.edu |
| Ryan | McCaarthy | Postdoctoral Fellow | ryanlm@pennmedicine.upenn.edu |
| Kenji | Ito | Postdoctoral Fellow | kenji.ito@pennmedicine.upenn.edu |
| Jingchao | Zhang | Postdoctoral Fellow | Jingchao.zhang@pennmedicine.upenn.edu |
| Megan | Frederick | Graduate Student | meganfr@pennmedicine.upenn.edu |
| Kelsey | Kaeding | Graduate Student | kkaeding@pennmedicine.upenn.edu |
| Edgar | Monteiro | Graduate Student | edgarluz@sas.upenn.edu |
| Andrew | Katznelson | Graduate Student | akatznel@pennmedicine.upenn.edu |
| Sweta | Narayan | Graduate Student | sweta.narayan@pennmedicine.upenn.edu |
| Nisha | Krishnan | Undergrauate Student | knisha@sas.upenn.edu |
| Greg | Donahue | Senior Data Analyst | gdonahue@pennmedicine.upenn.edu |
| Ann | O'Brien Jenkins | Research Specialist | aoj@pennmedicine.upenn.edu |
| Naomi | Takenaka | MA, Research Specialist, Lab Manager | ntaken@pennmedicine.upenn.edu |
| Melinda | Yin | Research Specialist | melinda.yin@pennmedicine.upenn.edu |