Mitchell A. Lazar, M.D., Ph.D.

Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases and Metabolic Diseases; Director of the Institute for Diabetes, Obesity, and Metabolism; Chief of Endocrinology Division, Diabetes, and Metabolism

University of Pennsylvania
The Perelman School of Medicine
Department of Medicine
Division of Endocrinology, Diabetes & Metabolism
Office: 12-102 Smilow Translational Research Center
Lab: 12-196 Smilow Translational Research Center
3400 Civic Center Blvd
Philadelphia, PA 19104
Fax: 215-898-5408

Office: 215-898-0198

•Discovery of thyroid hormone receptors and their mechanism of repression.

• Discovery of Nuclear Receptor Corepressor Complexes.

• Elucidation of physiological Roles of Nuclear Receptor Corepressors and HDAC3.

• Discovery of REV-ERB and mechanisms of circadian regulation of transcription and metabolism.

• Identification and characterization of PPAR g in Adipose Biology.

Research Interest

The goal of the Lazar lab is to understand the transcriptional regulation of circadian rhythms and metabolism both in normal physiology and in  metabolic diseases such as diabetes and obesity. The focus is on nuclear receptors and HDAC3-containing corepressor complexes, whose functions are interrogated using a combination of genomic, proteomic, bioinformatic, and metabolic phenotyping methods.  Of particular interest are the circadian REV-ERB nuclear receptors, which are transcriptional repressors that function in the circadian clock and coordinate biological rhythms of metabolism in liver, adipose, and other tissues. Another focus is on nuclear receptor PPARg, a key transcriptional link between obesity and diabetes which functions as the master regulator of adipocyte biology and whose ligands have potent antidiabetic activity. Nuclear receptors corepressors and HDAC3 are also of great interest as an integrators of the activities of nuclear receptors and other transcription factors, with tissue-specific functions that protect from challenges to the circadian, nutritional, and thermal environment.

Lab Members

AhrenAlbertoUndergraduates & Visiting/Rotating Students/
MichelleBurrowsLab Manager &
KirillBatmanovAffiliates &
IsaacCelwynLab Manager &
TiffanyFleetGraduate Students &
MaxFrankfurterUndergraduates & Visiting/Rotating Students/
AmyHauckGraduate Studnets &
Shin-IchiInoueGraduate Students &
MariaKriegLab Manager &
YifanLiuLab Manager &
Zhenyang "Natalie"LiuUndergraduates & Visiting/Rotating Students/
LilyMelinkLab Manager &
RashidMehmoodGraduate Students &
Mohit KMidhaGraduate Students &
KaanOralUndergraduates & Visiting/Rotating Students/
Yoon JeongParkGraduate Students &
MichaelTackenbergGraduate Students &
LaurenWoodieGraduate Students &
YangXiaoGraduate Students &
EricYangUndergraduates & Visiting/Rotating Students/
DelaineZayas-Bazán BurgosGraduate Students &
KunZhuGraduate Students &