Mitchell A. Lazar, M.D., Ph.D.
University of Pennsylvania
The Perelman School of Medicine
Department of Medicine
Division of Endocrinology, Diabetes & Metabolism
Office: 12-102 Smilow Translational Research Center
Lab: 12-196 Smilow Translational Research Center
3400 Civic Center Blvd
Philadelphia, PA 19104
•Discovery of thyroid hormone receptors and their mechanism of repression.
• Discovery of Nuclear Receptor Corepressor Complexes.
• Elucidation of physiological Roles of Nuclear Receptor Corepressors and HDAC3.
• Discovery of REV-ERB and mechanisms of circadian regulation of transcription and metabolism.
• Identification and characterization of PPAR g in Adipose Biology.
The goal of the Lazar lab is to understand the transcriptional regulation of circadian rhythms and metabolism both in normal physiology and in metabolic diseases such as diabetes and obesity. The focus is on nuclear receptors and HDAC3-containing corepressor complexes, whose functions are interrogated using a combination of genomic, proteomic, bioinformatic, and metabolic phenotyping methods. Of particular interest are the circadian REV-ERB nuclear receptors, which are transcriptional repressors that function in the circadian clock and coordinate biological rhythms of metabolism in liver, adipose, and other tissues. Another focus is on nuclear receptor PPARg, a key transcriptional link between obesity and diabetes which functions as the master regulator of adipocyte biology and whose ligands have potent antidiabetic activity. Nuclear receptors corepressors and HDAC3 are also of great interest as an integrators of the activities of nuclear receptors and other transcription factors, with tissue-specific functions that protect from challenges to the circadian, nutritional, and thermal environment.
|FIRST NAME||LAST NAME||GROUP|
|Ahren||Alberto||Undergraduates & Visiting/Rotating Students/Scientistsfirstname.lastname@example.org|
|Michelle||Burrows||Lab Manager & Techniciansemail@example.com|
|Kirill||Batmanov||Affiliates & Othersfirstname.lastname@example.org|
|Isaac||Celwyn||Lab Manager & Techniciansemail@example.com|
|Tiffany||Fleet||Graduate Students & Postdocsfirstname.lastname@example.org|
|Max||Frankfurter||Undergraduates & Visiting/Rotating Students/Scientistsemail@example.com|
|Amy||Hauck||Graduate Studnets & Postdocsfirstname.lastname@example.org|
|Shin-Ichi||Inoue||Graduate Students & Postdocsemail@example.com|
|Maria||Krieg||Lab Manager & Technicians||Maria.Kreig@pennmedicine.upenn.edu|
|Yifan||Liu||Lab Manager & Techniciansfirstname.lastname@example.org|
|Zhenyang "Natalie"||Liu||Undergraduates & Visiting/Rotating Students/Scientistsemail@example.com|
|Lily||Melink||Lab Manager & Technicians||Lily.Melink@pennmedicine.upenn.edu|
|Rashid||Mehmood||Graduate Students & Postdocs||Rashid.Mehmood@pennmedicine.upenn.edu|
|Mohit K||Midha||Graduate Students & Postdocs||Mohit.Midha@pennmedicine.upenn.edu|
|Kaan||Oral||Undergraduates & Visiting/Rotating Students/Scientistsfirstname.lastname@example.org|
|Yoon Jeong||Park||Graduate Students & Postdocs||YoonJeong.Park@pennmedicine.upenn.edu|
|Michael||Tackenberg||Graduate Students & Postdocsemail@example.com|
|Lauren||Woodie||Graduate Students & Postdocs||Lauren.Woodie@pennmedicine.upenn.edu|
|Yang||Xiao||Graduate Students & Postdocsfirstname.lastname@example.org|
|Eric||Yang||Undergraduates & Visiting/Rotating Students/Scientistsemail@example.com|
|Delaine||Zayas-Bazán Burgos||Graduate Students & Postdocfirstname.lastname@example.org|
|Kun||Zhu||Graduate Students & Postdoc||Kun.Zhu@pennmedicine.upenn.edu|