Roberto Bonasio, Ph.D.
The Perelman School of Medicine at the University of Pennsylvania
Department of Cell and Developmental Biology
9-111 Smilow Center for Translational Research
3400 Civic Center Blvd
Philadelphia, PA 19104-6059
The Bonasio laboratory investigates the molecular mechanisms of epigenetic memory with a focus on the role of noncoding RNAs. These processes are key to a number of biological phenomena, including embryonic development, cancer, stem cell pluripotency, and brain function. We approach these fundamental biological questions from both a mechanistic and systems-level perspective. We combine biochemistry and molecular biology with bioinformatics and genomics in conventional systems, such as mammalian cells, and nonconventional model organisms, such as ants, which offer new, unexplored avenues to study epigenetics.