Postdoctoral Research Fellow – Cremins Lab

Reposted: February 1, 2019,

Multiple Postdoc positions are available in 3D genome mapping and
engineering in human brain development and disease.

The Cremins Lab in the Department of Bioengineering, Department of
Genetics, and the Epigenetics Institute at the University of
Pennsylvania is recruiting multiple postdoctoral research fellows with
expertise in molecular biology and/or computational genomics. Projects
available involve the integration of 3D genome engineering with
high-resolution chromatin architecture analysis in human model systems
of the developing and diseased human brain. Candidates will be part of
an enthusiastic interdisciplinary team focused on analyzing 3-D
organization of epigenomes in the developing mammalian central nervous
system and understanding the possible functional role for 3D genome
folding using CRISPR/Cas9 genome editing. The laboratory space is
located in Penn’s Department of Bioengineering and laboratory members
have will have extensive involvement in the Epigenetics Institute in
Penn’s School of Medicine, thus providing a rich multi-disciplinary
training environment in molecular biology, genomics, epigenetics, stem
cells, bioinformatics and biostatistics.

Candidates are required to hold a PhD, MD, or both. For wet lab
candidates, preference will be given to enthusiastic and motivated
candidates with previous expertise in cell and molecular biology,
including some subset of: CRISPR/Cas9 genome editing cloning, qRT-PCR,
virus packaging, mammalian cell transduction, ChIPseq, or 3C/4C/5C/Hi-C.
For dry lab candidates, preference will be given to those with at least
4 years experience writing algorithms in python and
creating/implementing statistical methods to find patterns in large
genomics data sets and generate biologically-relevant, testable
hypotheses. We are interested in providing opportunities for postdocs to
cross-train across computational and experimental disciplines.

Applicants should submit a CV, a statement of research interests, and 3
or more references to jcremins@seas.upenn.edu