Cancer and Metabolic Epigenetics

The cancer epigenetics and metabolism program provides a forum to nucleate researcher at Penn studying interrelationships between chromatin state and cancer biology. Emerging evidence from this multidisciplinary group reveals that metabolic changes present in cancer cells not only affect energy balance and anabolic processes that support uncontrolled cellular proliferation during cancer, but also impact histone post-translational modifications and chromatin state. We seek to address fundamental questions regarding the mechanisms underlying these chromatin associated phenomena and how they influence transcription, DNA repair, cellular differentiation state, and other cancer phenotypes.

Director

Interest Group Members

Publications

From Ben Garcia Lab

Proteome-wide acetylation dynamics in human cells. Kori Y, Sidoli S, Yuan ZF, Lund PJ, Zhao X, Garcia BA. Sci Rep. 2017 Aug 31;7(1):10296.

From Roger Greenberg Lab

Mitotic progression following DNA damage enables pattern recognition within micronuclei. Harding SM, Benci JL, Irianto J, Discher DE, Minn AJ, Greenberg RA.  Nature. 2017 Aug 24;548(7668):466-470. DOI: 10.1038/nature23470. Epub 2017 Jul 31 PMID: 28759889

From Kathryn Wellen Lab

Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination. Sivanand S, Rhoades S, Jiang Q, Lee JV, Benci J, Zhang J, Yuan S, Viney I, Zhao S, Carrer A, Bennett MJ, Minn AJ, Weljie AM, Greenberg RA, Wellen KE. Mol Cell. 2017 Jul 20;67(2):252-265.e6. doi: 10.1016/j.molcel.2017.06.008. Epub 2017 2017 Jul 6. PMID:28689661

From Mitch Lazar Lab

Histone Deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge  Emmett MJ, Lim HW, Jager J, Richter HJ, Adlanmerini M, Peed LC, Briggs ER, Steger DJ, Ma T, Sims CA, Baur JA, Pei L, Won KJ, Seale P, Gerhart-Hines Z, Lazar MA.  Nature. 2017 Jun 22;546(7659):544-548. doi: 10.1038/nature22819. Epub 2017 Jun 14.

From Patrick Seale Lab

EBF2 transcriptionally regulares brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex. Shapira SN, Lim HW, Rajakumari S, Sakers AP, Ishibashia J, Harms MJ, Won KJ, Seale P. Genes Dev. 2017 Apr 1;31(7):660-673. doi: 10.1101/gad.294405.116. Epub 2017 Apr 20. PMID:28428261

From Shelley Berger Lab

RNA Binding to CBP Stimulates Histone Acetylation and Transcription  Bose DA, Donahue G, Reinberg D, Shiekhattar R, Bonasio R, Berger SL.  Cell. 2017 Jan 12;168(1-2):135-149.e22. doi:10.1016/j.cell.2016.12.020. Epub 2017 Jan 12. PMID:28086087