Interest Groups

At the Penn Epigenetics Institute, we love all facets of epigenetics. But we’ve come to appreciate that certain labs focus on similar areas of research, so we have established four different interest groups that serve our community: Cancer and Metabolic Epigenetics, Developmental Epigenetics, Spatial/Architectural Epigenetics, and Neuroepigenetics. Each interest group meets a few times a year – to find out when the next meeting is, visit our Events page!

Cancer and Metabolic Epigenetics

The cancer epigenetics and metabolism program provides a forum to nucleate researcher at Penn studying interrelationships between chromatin state and cancer biology. Emerging evidence from this multidisciplinary group reveals that metabolic changes present in cancer cells not only affect energy balance and anabolic processes that support uncontrolled cellular proliferation during cancer, but also impact histone post-translational modifications and chromatin state.

Developmental Epigenetics

The Developmental Epigenetics Interest Group addresses questions regarding epigenetic gene regulation in development and disease. For example, how does epigenetic gene regulation control lineage determination and cell identity? Additionally, how does disease and the environment impact epigenetic gene regulation? We use a variety of model systems, from mouse to plants, as well as in vitro systems in our studies.

Spatial / Architectural Epigenetics

Members of the Spatial/Architectural Epigenetics Interest Group Section are interested in the following questions: How is the genome is configured at various length scales? How is chromosomal topology influenced by chromatin modification and nuclear factors? Conversely, how does chromosomal topology impact transcription factor function, gene expression, and other nuclear processes?

Neuroepigenetics

The Neuroepigenetics Interest Group addresses questions regarding epigenetic regulation in the nervous system and disorders. Recent studies have shown dynamic regulation of various epigenetic modifications not only during the development of the nervous system, but also in the mature nervous system. We are interested in developing novel technologies to probe dynamic epigenetic modifications under normal physiology and disorders at the system and single cell levels.