The Neuroepigenetics Interest Group addresses questions regarding epigenetic regulation in the nervous system and disorders. Recent studies have shown dynamic regulation of various epigenetic modifications not only during the development of the nervous system, but also in the mature nervous system. We are interested in developing novel technologies to probe dynamic epigenetic modifications under normal physiology and disorders at the system and single cell levels. We are also interested in addressing the function and dysfunction of various epigenetic mechanisms in the nervous system at the molecular, cellular, circuitry and behavioral levels.

Director of Neuroepigenetics Interest Group

Hongjun Song, Ph.D. Perelman Professor of Neuroscience

Interest Group Members

Marisa Bartolomei, Ph.D. Perelman Professor of Cell and Developmental Biology; Co-Director of Epigenetics Institute
Shelley L. Berger, Ph.D. Daniel S. Och University Professor Director, Epigenetics Institute Penn Integrated Knowledge Professor (PIK)
Nancy M. Bonini, Ph.D. Florence R.C. Murray Professor of Biology
Elizabeth Heller, Ph.D. Assistant Professor of Pharmacology
Erica Korb, Ph.D Assistant Professor of Genetics
Jennifer E. Phillips-Cremins, Ph.D. Associate Professor of Bioengineering
Christopher Pierce, Ph.D., M.S. Professor of Neuroscience in Psychiatry
Yijing Su, Ph.D. Research Assistant Professor of Neuroscience
Hao Wu, Ph.D. Assistant Professor of Genetics
Zhaolan (Joe) Zhou, Ph.D. Associate Professor of Genetics


Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease.Nativio R, Donahue G, Berson A, Lan Y, Amlie-Wolf A, Tuzer F, Toledo JB, Gosai SJ, Gregory BD, Torres C, Trojanowski JQ, Wang LS, Johnson FB, Bonini NM, Berger SL. Nat Neurosci. 2018 Apr;21(4):497-505

Dissecting Cell-Type Composition and Activity-Dependent Transcriptional State in Mammalian Brains by Massively Parallel Single-Nucleus RNA-Seq. Hu P, Fabyanic E, Kwon DY, Tang S, Zhou Z, Wu H. Mol Cell. 2017 Dec 7;68(5):1006-1015.e7. doi: 10.1016/j.molcel.2017.11.017.

Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation. Yoon KJ, Ringeling FR, Vissers C, Jacob F, Pokrass M, Jimenez-Cyrus D, Su Y, Kim NS, Zhu Y, Zheng L, Kim S, Wang X, Doré LC, Jin P, Regot S, Zhuang X, Canzar S, He C, Ming GL, Song H.Cell. 2017 Nov 2;171(4):877-889.e17

Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome. Johnson BS, Zhao YT, Fasolino M, Lamonica JM, Kim YJ, Georgakilas G, Wood KH, Bu D, Cui Y, Goffin D, Vahedi G, Kim TH, Zhou Z. Nat Med. 2017 Oct;23(10):1203-1214. doi: 10.1038/nm.4406.