Neuroepigenetics

The Neuroepigenetics Interest Group addresses questions regarding epigenetic regulation in the nervous system and disorders. Recent studies have shown dynamic regulation of various epigenetic modifications not only during the development of the nervous system, but also in the mature nervous system. We are interested in developing novel technologies to probe dynamic epigenetic modifications under normal physiology and disorders at the system and single cell levels. We are also interested in addressing the function and dysfunction of various epigenetic mechanisms in the nervous system at the molecular, cellular, circuitry and behavioral levels.

Director

Interest Group Members

Publications

From Shelley Berger Lab

Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease. Nativio R, Donahue G, Berson A, Lan Y, Amlie-Wolf A, Tuzer F, Toledo JB, Gosai SJ, Gregory BD, Torres C, Trojanowski JQ, Wang LS, Johnson FB, Bonini NM, Berger SL. Nat Neurosci. 2018 Apr;21(4):497-505. doi: 10.1038/s41593-018-0101-9.

From Shelley Berger Lab

Dysregulation of the epigenetic landscape of normal aging in Alzheimer’s disease. Nativio R, Donahue G, Berson A, Lan Y, Amlie-Wolf A, Tuzer F, Toledo JB, Gosai SJ, Gregory BD, Torres C, Trojanowski JQ, Wang LS, Johnson FB, Bonini NM, Berger SL. Nat Neurosci. 2018 Apr;21(4):497-505. doi: 10.1038/s41593-018-0101-9.

From Hao Wu Lab

Dissecting Cell-Type Composition and Activity-Dependent Transcriptional State in Mammalian Brains by Massively Parallel Single-Nucleus RNA-Seq. Hu P, Fabyanic E, Kwon DY, Tang S, Zhou Z, Wu H.  Mol Cell. 2017 Dec 7;68(5):1006-1015.e7. doi: 10.1016/j.molcel.2017.11.017.

From Hongjun Song Lab

Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation. Ki-Jun Yoon, Francisca Rojas Ringeling, Caroline Vissers, Fadi Jacob, Michael Pokrass, Dennisse Jimenez-Cyrus, Yijing SU, Nam-Shik Kim, Yunhua Zhu, Lily Zheng, Sungan Kim, Xinyuan Wang, Lousic C. Dore, Pen Jin, Sergi Regot, Jaoxi Zhuang, Stefan Canzar, Chuan He, Guo-li Ming, Hongjun Song.  DOI: dx.doi.org10.1016/j.cell.2017.09.003.

From Zhaolan Zhou Lab

Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome. Johnson BS, Zhao YT, Fasolino M, Lamonica JM, Kim YJ, Georgakilas G, Wood KH, Bu D, Cui Y, Goffin D, Vahedi G, Kim TH, Zhou Z.  Nat Med. 2017 Oct;23(10):1203-1214.