The Penn Epigenetics Institute announces a request for applications of a Pilot Project Grant for faculty to conduct Epigenetics-related research projects. A broad spectrum of proposal topics will be considered. Including those that involve fundamental studies in Epigenetics as well as more applied or disease-oriented studies that utilize Epigenetics as a central component of the research.
Award Amount & Duration: Up to $50,000 for a 1-year pilot project. Renewable for a second year of funding.
Award Dates:
Application Receipt Deadline: May 2, 2022, at 11:59 pm
Notification of Award: June 6, 2022
Funding Period: July 1, 2022 – June 30, 2023
Apply Here: https://upenn.co1.qualtrics.com/jfe/form/SV_4GfDeJRFp6uUJhQ
2023 At-Large Epi Pilot Grant RFA
Past At-Large Epigenetics Pilot Grant Awardees
| Year(s) Awarded | Investigator(s) | Title of Project | Publication(s) | Grant Submission(s) |
|---|---|---|---|---|
| 2023 | George Burslem, Ph.D. & Andrey Poleshko, Ph.D. | Unbiased Probe Discover for Epigenetics Reprogramming | N/A | N/A |
| 2023 | Wanding Zhou, Ph.D., 8 Rahul Kohli, M.D., Ph.D. & Marisa Bartolomei, Ph.D. | Comprehensive resolution of epigenome diversity using the ternary-code DNA modification | N/A | N/A |
| 2023 | Erica Korb, Ph.D. & George Burslem, Ph.D. | Developing tools to examine the role and regulation of histone crotonylation in the brain | N/A | N/A |
| 2020 | Brian Capell, M.D., Ph.D & Kathy Fange Liu, Ph.D. | Defining the m6A epitranscriptome in epithelial gene regulaLon, development, and carcinogenesis | N/A | N/A |
| 2020 | Roberto Bonasio, Ph.D. & Elizabeth Heller, Ph.D. | In search of the epigeneQc engram in planarians | N/A | N/A |
| 2019 & 2020 | Elizabeth Heller, Ph.D. & Zhaolan Zhou, Ph.D. | Application of a novel method for neuronal cell-type specific simultaneous transcriptome and epigenome profiling in vivo in mice | N/A | N/A |
| 2019 & 2020 | Junwei Shi, Ph.D. | Develop a Cas 12a-based genetic method to identify paired epigenetic dependencies in acute myeloid leukemia | N/A | N/A |
| 2018 & 2019 | Eric Joyce, Ph.D., Melike Lakadamyali, Ph.D. & Rajan Jain, M.D. | Inheritance of Lamin-associated domains and their role in maintaining cellular identity | N/A | N/A |
| 2018 & 2019 | Maya Capelson, Ph.D. & Eric Joyce, Ph.D. | Identifying regulators of nuclear gene positioning via a high-throughput imaging screen. | Alejandro Gozalo, Ashley Duke, Yemin Lan, Pau Pascual-Garcia, Jessica A. Talamas, Son Nguyen, Eric F. Joyce and Maya Capelson. Core components of the nuclear pore bind distinct states of chromatin and contribute to Polycomb repression. In review at Mol Cell | N/A |
| 2017 & 2018 | Hao Wu, Ph.D. & Rahul M. Kohli, M.D., Ph.D. | APOBEC-Coupled Epigenetic Sequencing | EK Schutsky, JE DeNizio, P Hu, MY Liu, CS Nabel, EB Fabyanic, Y Hwang, FD Bushman, H Wu, RM Kohli, Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase. Nature Biotechnology, accepted on 24 May 2018. | N/A |
| 2017 & 2018 | Golnaz Vahedi, Ph.D. & Nancy A. Speck, Ph.D | Uncovering regulatory coordination during T cell development using single-cell epigenomics | N/A | Submitted to NIDDK in May 2018 |
| 2015 & 2017 | Benjamin Garcia, Ph.D. | A novel mass spectrometry based platform for characterization of microRNA (miRNA) post-transcriptional modifications | N/A | N/A |
| 2015 & 2017 | Robert Babak Faryabi, Ph.D. & Warren S. Pear, M.D., Ph.D. | Interrogating the oncogenic enhancer landscape in B cell lymphoma | Notch-Regulated Enhancers in B-Cell Lymphoma Activate MYC and Potentiate B-Cell Receptor Signaling. Russell JH Ryan, Jelena Petrovic, Dylan Rausch, Caleb Lareau, Winston Lee, Laura Donohue, Amanda L Christie, Shawn Gillespie, Michael J Kluk, Valentina Nardi, Robert B Faryabi, Ephraim P Hochberg, David M Weinstock, Bradley E Bernstein, Jon C Aster, Warren S Pear. Blood Dec 2016. | 1) Targeting the Notch:Myc axis in leukemia/lymphoma, NCI R01. Scored at 12th percentile (Nov 2016), current NCI payline is 10th percentile. 2) Oncogenic Notch Signaling P01 (submitted September 2016) |
| 2015 | Arjun Raj, Ph.D. & Roberto Bonasio, Ph.D. | CRISPR Drop-seq | N/A | N/A |
| 2013 & 2014 | Ben Black, Ph.D. & Michael Lampson, Ph.D. | Maintaining centromere identity in mammalian oocytes | N/A | N/A |
| 2013 & 2014 | Hua-Ying Fan, Ph.D. | Mechanisms of Transcription Memory Maintenance by the Notch Pathway Effector RBPJ | RBPJ, the major transcriptional effector of Notch signaling, remains associated with chromatin throughout mitosis, suggesting a role in mitotic bookmarking. Lake RJ, Tsai PF, Choi I, Won KJ, Fan HY. PLoS Genet. 2014 Mar 6;10(3):e1004204. doi: 10.1371/journal.pgen.1004204. eCollection 2014 Mar. Erratum in: PLoS Genet. 2016 Jul;12(7):e1006209. PMID:24603501 | NIH/NIGMS 1R01GM114132-01 Title: Mechanistic basis for mitotic transcriptional memory |
| 2013 & 2014 | Maya Capelson, Ph.D. & Sara Cherry, Ph.D. | Defining Role of Nuclear Pore Proteins in Antiviral Gene Expression | Nup98 promotes antiviral gene expression to restrict RNA viral infection in Drosophila. Panda D, Pascual-Garcia P, Dunagin M, Tudor M, Hopkins KC, Xu J, Gold B, Raj A, Capelson M, Cherry S.Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):E3890-9. doi: 10.1073/pnas.1410087111. Epub 2014 Sep 2. PMID:25197089 | N/A |