Developmental Epigenetics

The Developmental Epigenetics Interest Group addresses questions regarding epigenetic gene regulation in development and disease. For example, how does epigenetic gene regulation control lineage determination and cell identity? Additionally, how does disease and the environment impact epigenetic gene regulation? We use a variety of model systems, from mouse to plants, as well as in vitro systems in our studies. We also pursue genetic and biochemical studies that focus on the epigenetic machinery. To address these questions at the single cell level, in tissues or in organisms, we use state-of-the art tools and computation.

Publications

From Ken Zaret Lab

MITOTIC TRANSCRIPTION AND WAVES OF GENE REACTIVATION DURING MITOTIC EXIT

Mitotic transcription and waves of gene reactivation during mitotic exit. Katherine C. Palozola, Greg, Donahue, Hong Liu, Gregory R Grant, Justin S. Becker, Allison Cote, Hongtao Yu, Arjun Raj, Kenneth S. Zaret. Published Online 12 Sep 2017 full access. doi: 10.1126/science.aal4671

From Roberto Bonasio LabDoris Wagner Lab

CIS AND TRANS DETERMINANTS OF EPIGENETIC SILENCING BY POLYCOMB REPRESSIVE COMPLEX 2 IN ARABIDOPSIS

Cis and trans determinants of epigenetic silencing by Polycomb repressive complex 2 in Arabidopsis. Xiao J, Jin R, Yu X, Shen M, Wagner JD, Pai A, Song C, Zhuang M, Klasfeld S, He C, Santos AM, Helliwell C, Pruneda-Paz JL, Kay SA, Lin X, Cui S, Garcia MF, Clarenz O, Goodrich J, Zhang X, Austin RS, Bonasio R, Wagner D. Nat Genet. 2017 Aug 21. doi: 10.1038/ng.3937.

From Roberto Bonasio Lab

THE NEUROPEPTIDE CORAZONIN CONTROLS SOCIAL BEHAVIOR AND CASTE IDENTITY IN ANTS

The Neuropeptide Corazonin Controls Social Behavior and Caste Identity in Ants. Gospocic J, Shields EJ, Glastad KM, Lin Y, Penick CA, Yan H, Mikheyev AS, Linksvayer TA, Garcia BA, Berger SL, Liebig J, Reinberg D, Bonasio R. Cell. 2017 Aug 10;170(4):748-759.e12. doi: 10.1016/j.cell.2017.07.014

From Zhaolan Zhou Lab

ELEVATING EXPRESSION OF MECP2 T158M RESCUES DNA BINDING AND RETT SYNDROME-LIKE PHENOTYPES

Elevating expression of MeCP2 T158M rescues DNA binding and Rett syndrome-like phenotypes. Lamonica JM, Kwon DY, Goffin D, Fenik P, Johnson BS, Cui Y, Guo H, Veasey S, and Zhou Z. Journal of Clinical Investigation 127(5): 1889-1904,2017.

From Klaus Kaestner Lab

EPIGENETIC REGULATION OF INTESTINAL STEM CELLS BY TET 1-MEDIATED DNA HYDROXYMETHYLATION

Epigenetic regulation of intestinal stem cells by Tet 1-mediated DNA hydroxymethylation. Kim R, Sheaffer KL, Choi I, Won KJ, Kaestner KH. Genes Dev. 2016

From Arjun Raj Lab

VISUALIZING ALLELE-SPECIFIC EXPRESSION IN SINGLE CELLS REVEALS EPIGENETIC MOSAICISM IN AN H19 LOSS OF IMPRINTING MUTANT

Visualizing allele-specific expression in single cells reveals epigenetic mosaicism in an H19 loss of imprinting mutant. Ginard, P., Kalish, J.M., Jiang, C.L., Yu, A.C., Bartolomei, M.S.* and A. Raj*. (2016). Genes and Development, 30:567-578