• Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics

Announcement: The Garcia Lab will be moving to the Washington University School of Medicine in St. Louis in the summer of 2021. Ben will become the next Head of the Dept of Biochemistry and Molecular Biophysics and also help guide the development of a new Mass Spectrometry Center! Press release can be read here.

 

Welcome to the Garcia Lab

“Spectrometry for the Masses”

The Garcia Lab utilizes high-resolution mass spectrometry to explore cellular signaling, epigenetic mechanisms and chromatin regulation.  We are especially interested in understanding how protein and nucleic acid modifications mediate their canonical functions and regulate nuclear processes. Mass spectrometry has become an unparalleled tool in the analysis of these biological molecules and allows us to obtain quantitative information about modifications as well as their co-occurrence. These modifications are critical for nuclear stability and transcription; and dysregulation of these pathways underlie several human diseases such as cancer.  Our work aims to reveal the roles of these modifications in the cell cycle, proliferation, differentiation, signaling pathways and metabolism, to consequently help elucidate the mechanisms of various diseases.

 

December 2020

Collaboration with the Bhoj lab (CHOP) on new discoveries of histone H3.3 mutations in unidentified neurodevelopmental disorders is published in Science Advances.

Kevin Janssen has successfully defended his thesis! Congrats! He will next be a postdoc at the Children’s Hospital of Philadelphia (CHOP).

Khadija has been selected to participate in the 2021 St. Jude National Graduate Student Symposium (NGSS), congrats!

The lab says goodbye to Congcong who will be going back to China for her next career move as an Assistant Professor at Nankai University, congrats!

Collaborations with the Skoultchi lab (Albert Einstein) and Eckenhoff Lab (UPenn) to understand how histone H1 controls chromatin compaction, and to characterize volatile anesthetic drug binding sites in the TREK1 K2P channel are published in Nature and Elife, respectively.

Mariel Coradin successfully defends her thesis! Congratulations and best of luck in your new postdoctoral position in Colorado!

The Garcia Lab welcomes Axe Xie to the lab as our newest postdoc!

November 2020

Congcong’s review on proteomic approaches for epigenetics research is published in MCP, congrats!

Collaborations with the Jabado lab on the K27M induced methylation changes in gliomas, and with the Bonasio lab to understand how TET2 regulates tRNA fragments are published in Cell Reports and NSMB, respectively.

Peder is selected for the ASMS Emerging Talent program, congrats!