The Garcia Lab utilizes high-resolution mass spectrometry to explore cellular signaling, epigenetic mechanisms and chromatin regulation. We are especially interested in understanding how protein and nucleic acid modifications mediate their canonical functions and regulate nuclear processes. Mass spectrometry has become an unparalleled tool in the analysis of these biological molecules and allows us to obtain quantitative information about modifications as well as their co-occurrence. These modifications are critical for nuclear stability and transcription; and dysregulation of these pathways underlie several human diseases such as cancer. Our work aims to reveal the roles of these modifications in the cell cycle, proliferation, differentiation, signaling pathways and metabolism, to consequently help elucidate the mechanisms of various diseases.
September 2021
Congratulations to Khadija who successfully defended her thesis!
July 2021
The Garcia Lab has relocated to the Washington University School of Medicine in St. Louis!
The Garcia Lab welcomes Faith Robison as the new Mass Spectrometry Manager/Scientist. Faith previously worked at ThermoFisher Scientific as a Field Service Engineer and Supervisor.
The Garcia Lab welcomes Xingyu Liu as a new postdoc to the group. Xingyu earned her PhD at the Stowers Institute co-advised by Jerry Workman and Michael Washburn.
Ben has been elected as an Alternate Councilor for the ACS Division of Analytical Chemistry.