• Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics

Welcome to the Garcia Lab

“Spectrometry for the Masses”

The Garcia Lab utilizes high-resolution mass spectrometry to explore cellular signaling, epigenetic mechanisms and chromatin regulation.  We are especially interested in understanding how protein and nucleic acid modifications mediate their canonical functions and regulate nuclear processes. Mass spectrometry has become an unparalleled tool in the analysis of these biological molecules and allows us to obtain quantitative information about modifications as well as their co-occurrence. These modifications are critical for nuclear stability and transcription; and dysregulation of these pathways underlie several human diseases such as cancer.  Our work aims to reveal the roles of these modifications in the cell cycle, proliferation, differentiation, signaling pathways and metabolism, to consequently help elucidate the mechanisms of various diseases. The Garcia Lab is part of the Epigenetics Institute and Department of Biochemistry and Biophysics here at the University of Pennsylvania School of Medicine.

February 2020

The Garcia Lab is on Twitter!

Yekaterina has been awarded an American Society for Mass Spectrometry Graduate Travel Award to attend the annual conference in Houston this summer, congrats!

Sam’s research work on building a computational framework for analysis of modified RNA MS/MS spectra is published in Nature Communications, congrats!

Ben was interviewed for the Real Science Real Life Podcast.

Yekaterina presented at the Women in STEM Symposium at Penn, and this was mentioned in Penn Today!

Mariel C and Mariel M publish their Middle Down proteomics workflow in the journal Methods, nice work!

January 2020

Many lab publications have come out. Our collaborations with the Lakdawala and Wojcik labs to understand intracellular transport of viral RNA and to create a new method for proteomics analysis of FFPE tissue are published in Nature Communications and the Journal of Proteome Research, respectively. Additionally, Kevin’s manuscript to describe a combined approach for Bottom up and Middle down analysis of histones is published in JASMS.