• Quantitative Systems Mass Spectrometry
  • Quantitative Systems Mass Spectrometry
  • Quantitative Systems Mass Spectrometry
  • Quantitative Systems Mass Spectrometry
  • Quantitative Systems Mass Spectrometry
  • Quantitative Systems Mass Spectrometry
  • Quantitative Systems Mass Spectrometry
  • Quantitative Systems Mass Spectrometry

Announcement: The Garcia Lab will be moving to the Washington University School of Medicine in St. Louis in the summer of 2021. Ben will become the next Head of the Dept of Biochemistry and Molecular Biophysics and also help guide the development of a new Mass Spectrometry Center! Press release can be read here.

 

Welcome to the Garcia Lab

“Spectrometry for the Masses”

The Garcia Lab utilizes high-resolution mass spectrometry to explore cellular signaling, epigenetic mechanisms and chromatin regulation.  We are especially interested in understanding how protein and nucleic acid modifications mediate their canonical functions and regulate nuclear processes. Mass spectrometry has become an unparalleled tool in the analysis of these biological molecules and allows us to obtain quantitative information about modifications as well as their co-occurrence. These modifications are critical for nuclear stability and transcription; and dysregulation of these pathways underlie several human diseases such as cancer.  Our work aims to reveal the roles of these modifications in the cell cycle, proliferation, differentiation, signaling pathways and metabolism, to consequently help elucidate the mechanisms of various diseases.

 

April 2021

The lab says farewell to Kevin and Stephanie, who are off to a postdoc at CHOP and new position at GSK, respectively.

Neha has been awarded an American Chemical Society (ACS) Division of Analytical Chemistry Summer Graduate Fellowship, congrats!!

Congcong’s work describing the characterization of histone H3 combinatorial modifications during the cell cycle is published in JASMS.

Michael has been awarded an NIH NRSA Predoctoral Fellowship, great job!

March 2021

Lindsay’s study to develop a new SILAC-DIA-MS workflow is published in the Journal of Proteome Research, and also has been highlighted here.