• Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics
  • Quantitative Mass Spectrometry for Systems Epigenetics

Welcome to the Garcia Lab

“Spectrometry for the Masses”

The Garcia Lab utilizes high-resolution mass spectrometry to explore cellular signaling, epigenetic mechanisms and chromatin regulation.  We are especially interested in understanding how protein and nucleic acid modifications mediate their canonical functions and regulate nuclear processes. Mass spectrometry has become an unparalleled tool in the analysis of these biological molecules and allows us to obtain quantitative information about modifications as well as their co-occurrence. These modifications are critical for nuclear stability and transcription; and dysregulation of these pathways underlie several human diseases such as cancer.  Our work aims to reveal the roles of these modifications in the cell cycle, proliferation, differentiation, signaling pathways and metabolism, to consequently help elucidate the mechanisms of various diseases. The Garcia Lab is part of the Epigenetics Institute and Department of Biochemistry and Biophysics here at the University of Pennsylvania School of Medicine.

August 2020

The Lab says good to Jen as she starts the next chapter of her career at the University of Connecticut Proteomics Facility, congrats!

July 2020

Lindsay is awarded a postdoctoral fellowship slot on the Immunology of Normal and Neoplastic Lymphocytes NIH T32 training grant, congrats!!

A collaboration with the Josefowicz lab (Weill Cornell) on the role of histone H3.3 in stimulated macrophages is published in Nature, while Kevin’s collaboration with the Gregory lab (UPenn) to understand how m6A deposition induces loss of RNA secondary structure resulting in changes in mRNA stability for transcripts encoding abiotic stress response is published in Plant Direct.

Richard’s collaboration with the Weitzman lab (CHOP) on how Adenovirus induced ubquitination affects RNA-protein interactions is published in Nature Microbiology.

The lab says goodbye to Abby who will start graduate school at Memorial Sloan Kettering soon, best of luck!

A collaboration with the Dou lab (Univ. of Michigan) on the role of the acetyltransferase MOF during cellular quiescence is published in Cell Stem Cell.