Archive for 2019

December 2019

A special issue in honor of Ben receiving the ASMS Biemann Medal is published in the Journal of the American Society for Mass Spectrometry, see here.

Khadija won 3rd place in the poster competition at the Fox Chase Cancer Center Epigenetics Symposium, congrats!

Mariel C and Amber were selected to attend the 2020 St. Jude National Graduate Student Symposium (NGSS), they are one of only 38 students selected from over 1500 invited to apply!

November 2019

Dylan defends his PhD thesis, becoming the 10th PhD graduate from the Garcia Lab, congratulations and best of luck at Agios!

Laura publishes her work on improved detection of proteoforms using deep proteomics analyses and custom RNA databases in Genome Research, congrats.

October 2019

Our new collaborative study with the Berger lab (UPenn) on how alcohol contributes to histone acetylation in the brain to influence alcohol-related associative learning is published in Nature.

New collaborative manuscripts describing development of a novel α2 adrenergic agonist photolabel with the Eckenhoff lab (UPenn), and  cross-talk between histone H3K23 and H3K14 acetylation with the Kutateladze lab (University of Colorado) are published in ACS Chemical Neuroscience and Nature Communications, respectively.

Peder and Stephanie’s protocols for lysine methylation characterization by MS is published in Methods in Enzymology, congrats!

Ben, Abby, Bhanu, Mariel C and Dylan return from a great visit to St. Jude Children’s Hospital for our Chromatin Consortium collaboration meeting.

September 2019

The lab says goodbye to Zuo-Fei, good luck in Memphis!

Ben has been re-elected to the United States Human Proteome Organization (US-HUPO) Board of Directors for another 3-year term.

Simone’s manuscript describing a method to assess chromatin compaction by MS is published in Scientific Reports, congrats!

Our new postdoc Lindsay Pino has arrived, welcome to the Garcia Lab!

Super M has received an NIH NRSA F31 Predoctoral Fellowship, congrats!

Ben has received the Distinguished Lectureship Award from the New Jersey American Chemical Society Mass Spectrometry Discussion Group.

Kevin publishes his work on simultaneous detection and quantification of single and combinatorial histone PTMs using a novel chromatographic approach to perform Bottom Up and Middle Down experiments in a single run in JASMS, congrats!

Collaborations with the Allis lab on the connection between DNA methylation and histone H3K36 methylation, and with the Reinberg lab on understanding the automethylation activity of PRC2 are published in Nature and Genes & Development, respectively.

Ben has been re-elected to the Human Proteome Organization (HUPO) governing council (Western region representative) for another 3-year term.

The Garcia Lab welcomes 1st year BMB  student Adriana Santiago-Ruiz to the lab for the fall rotation.

August 2019

Yekaterina has been awarded a Blavatnik Family Graduate Fellowship in Biomedical Research, congrats!

Mariel C, Bella and Zuo-Fei present posters at the UPenn Chemistry Biology Interface Symposium, where Mariel was awarded first place.

July 2019

The Garcia Lab welcomes Avi, Bella and Paige, our summer HS students to the lab.

Collaborations with the Wallace lab (CHOP) and Blau lab (Stanford) describing mitochondrial regulation of the epigenome, and the role of histone acetylation in muscle regeneration are published in PNAS and Cell Reports, respectively. Kevin and Peder led the Garcia Lab effort on these collaborations.

June 2019

The Garcia Lab comes back from a great ASMS Conference where we had talks from Josue, Mariel C, Zuo-Fei, and Amber. We also had posters from Yekaterina, Joe, Abby, Simone, Bhanu, Khadija, Dylan, Super M, Kevin and Stephanie. Additionally, Josue was awarded the postdoctoral Award, Mariel M. a graduate student travel award, and Abby an undergraduate student travel award.

The Garcia Lab welcomes new BMB graduate student members Michael Gilbert, Janice Reynaga and Neha Srikumar to the group!

Dylan and Anumita publish their research on more accurate biomarkers for malignant peripheral nerve sheath tumors and microfluidic approaches for single cell proteomics in Modern Pathology and Analytical Chemistry, respectively.

The Garcia Lab welcomes new BMB rotation student Julia Tasca to the lab for a summer rotation.

Super M was named a finalist for the HHMI Gilliam Fellowship, congrats.

 

May 2019

The lab’s new publication describing a new ultra-throughput analysis of histone modifications is published in Genome Research.

Amber wins a poster award at the Children’s Hospital of Philadelphia Research Institute Poster Day and Symposium, congrats!

The Garcia Lab welcomes new postdoc Libby Porter to the group!

Yekaterina receives a travel award from the Delaware Valley MS Discussion Group to attend the upcoming ASMS conference where she will be presenting a poster, congrats!

Collaborations with the Lewis lab (Univ. of Wisconsin) on an ‘oncohistone-mimic’, Stephen Mack (Baylor College of Medicine) on K27M oncohistone mechanisms in gliomas, and the Blobel lab (CHOP) on new regulators of fetal hemoglobin (HbF) production are published in Nature Communication,  Cancer Cell, and Blood Advances, respectively.

Yekaterina has been selected as a finalist for the Blavatnik Family Graduate Fellowship.

April 2019

Khadija and Hee Jong have passed their 2nd year prelim examinations, congrats!

Peder and Yekaterina’s methods article on protein acetylation is published in Methods in Molecular Biology, and a collaboration with the Blobel lab (CHOP) on the role of histone acetylation during mitotic transcription is published in Cell Reports.

Khadija is awarded an NSF Graduate Fellowship, and Hee Jong is named Honorable Mention for the NSF Graduate Fellowship, congratulations to both!

Abby wins the Garcia Lab 9th Floor Ballers NCAA Bracket Tournament Challenge, correctly being the only one to select UVa as the Champion. Ben and Peder finished a respectable 2nd and 3rd. “Auburn Joe” is born, and Amber, please stick to surface proteins

The Garcia lab welcomes visiting graduate student Hilde von Gruning (University of Pretoria) to the group for a short research collaboration stay.

March 2019

Collaborations with the Morrisey lab (UPenn) to study transcriptional factors that regulate lung epithelial homeostasis and with the Allis lab (Rockefeller University) to determine the cellular target of menin inhibition in glioma are published in Gene & Development and PNAS, respectively.

John’s work on the epigenetic mechanisms in MPNST cancers is published in Cancer Research, congrats!

Yekaterina gave a talk, and our former summer HS student Bella presented a poster at the Pittcon Conference in Philadelphia, PA.

Collaborations with the Maze lab (Mt. Sinai) on a new histone modification sertonylation, and with the Jabado lab (McGill University) to further understand how the H3K27M mutation affects H3K27 methylation spreading are published in Nature and Nature Communications, respectively. Additionally,  Bhanu’s work describing signaling cross-talk with a trans-histone code during myogenesis is published in the Journal of Biological Chemistry, congrats.

The Garcia Lab is the featured lab of the month on the Epigenetics Institute website, check out the video here, and the Garcia Lab blog post here.

The Garcia Lab will have 4 talks (Josue, Zuo-Fei, Amber and Mariel C), and 12 posters at the ASMS Conference later this year, watch out Atlanta!

The Garcia Lab returns from the US HUPO Conference in Rockville, MD. Mariel C., Peder and Richard gave short talks; Khadija, Zuo-Fei, Kasia and Congcong gave lightning talks; Yekaterina gave a Tips & Tricks talk and Ben gave an invited talk. We also had poster presentations from Josue, Yekaterina, Jen, Khadija, Joe, Kasia, Abby, Bhanu, Zuo-Fei, Congcong and Super M. Last but not least, Yekaterina also won first place in the graduate student poster competition!

Richard’s collaboration with the Bonasio and Davidovich labs to map RNA-protein binding sites on the EZH2 complex that influence its activity is published in Nat Struct Mol Biol.

Mariel C. has been selected to attend the Lindau Nobel Laureate meeting in Germany, congrats!

Sam successfully defends his PhD thesis, congratulations Dr. Wein!

The Garcia Lab says goodbye to Simone, who is off to start his independent faculty position at the Einstein College of Medicine, you’ll be missed, best of luck!