Deep profiling and custom databases improve detection of proteoforms generated by alternative splicing. Agosto LM, Gazzara MR, Radens CM, Sidoli S, Baeza J, Garcia BA, Lynch KW. Genome Res. 2019 Dec;29(12):2046-2055.
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Archive for 2019
Deep profiling and custom databases improve detection of proteoforms generated by alternative splicing
Alcohol metabolism contributes to brain histone acetylation
Alcohol metabolism contributes to brain histone acetylation. Mews P, Egervari G, Nativio R, Sidoli S, Donahue G, Lombroso SI, Alexander DC, Riesche SL, Heller EA, Nestler EJ, Garcia BA, Berger SL. Nature. 2019 Oct;574(7780):717-721.
Recognition of Histone Crotonylation by Taf14 Links Metabolic State to Gene Expression
Recognition of Histone Crotonylation by Taf14 Links Metabolic State to Gene Expression. Gowans GJ, Bridgers JB, Zhang J, Dronamraju R, Burnetti A, King DA, Thiengmany AV, Shinsky SA, Bhanu NV, Garcia BA, Buchler NE, Strahl BD, Morrison AJ. Mol Cell. 2019 Oct 23. pii: S1097-2765(19)30734-8.
Azi-medetomidine: Synthesis and Characterization of a Novel α2 Adrenergic Photoaffinity Ligand
Azi-medetomidine: Synthesis and Characterization of a Novel α2 Adrenergic Photoaffinity Ligand. McKinstry-Wu AR, Woll KA, Joseph TT, Bu W, White ER, Bhanu NV, Garcia BA, Brannigan G, Dailey WP, Eckenhoff RG. ACS Chem Neurosci. 2019 Nov 20;10(11):4716-4728.
Quantitative analysis of global protein lysine methylation by mass spectrometry
Quantitative analysis of global protein lysine methylation by mass spectrometry. Lund PJ, Lehman SM, Garcia BA. Methods Enzymol. 2019;626:475-498.
Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation
Histone H3K23-specific acetylation by MORF is coupled to H3K14 acylation. Klein BJ, Jang SM, Lachance C, Mi W, Lyu J, Sakuraba S, Krajewski K, Wang WW, Sidoli S, Liu J, Zhang Y, Wang X, Warfield BM, Kueh AJ, Voss AK, Thomas T, Garcia BA, Liu WR, Strahl BD, Kono H, Li W, Shi X, Côté J, Kutateladze TG. Nat Commun. 2019 Oct 17;10(1):4724.
A mass spectrometry-based assay using metabolic labeling to rapidly monitor chromatin accessibility of modified histone proteins
A mass spectrometry-based assay using metabolic labeling to rapidly monitor chromatin accessibility of modified histone proteins. Sidoli S, Lopes M, Lund PJ, Goldman N, Fasolino M, Coradin M, Kulej K, Bhanu NV, Vahedi G, Garcia BA. Sci Rep. 2019 Sep 20;9(1):13613.
Quantitation of Single and Combinatorial Histone Modifications by Integrated Chromatography of Bottom-up Peptides and Middle-down Polypeptide Tails
Quantitation of Single and Combinatorial Histone Modifications by Integrated Chromatography of Bottom-up Peptides and Middle-down Polypeptide Tails. Janssen KA, Coradin M, Lu C, Sidoli S, Garcia BA. J Am Soc Mass Spectrom. 2019 Dec;30(12):2449-2459.
Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma
Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma. Lee CH, Yu JR, Granat J, Saldaña-Meyer R, Andrade J, LeRoy G, Jin Y, Lund P, Stafford JM, Garcia BA, Ueberheide B, Reinberg D. Genes Dev. 2019 Oct 1;33(19-20):1428-1440.
The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape
The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape. Weinberg DN, Papillon-Cavanagh S, Chen H, Yue Y, Chen X, Rajagopalan KN, Horth C, McGuire JT, Xu X, Nikbakht H, Lemiesz AE, Marchione DM, Marunde MR, Meiners MJ, Cheek MA, Keogh MC, Bareke E, Djedid A, Harutyunyan AS, Jabado N, Garcia BA, Li H, Allis CD, Majewski J, Lu C. Nature. 2019 Sep;573(7773):281-286.