Publications

Archive for 2019

PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation

PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation. Ren Z, Ahn JH, Liu H, Tsai YH, Bhanu NV, Koss B, Allison DF, Ma A, Storey AJ, Wang P, Mackintosh SG, Edmondson RD, Groen RWJ, Martens AC, Garcia BA, Tackett AJ, Jin J, Cai L, Zheng D, Wang GG. Blood. 2019 Aug 5. pii: blood.2019000578. doi: 10.1182/blood.2019000578. [Epub ahead of print]

Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy

Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy. Kopinski PK, Janssen KA, Schaefer PM, Trefely S, Perry CE, Potluri P, Tintos-Hernandez JA, Singh LN, Karch KR, Campbell SL, Doan MT, Jiang H, Nissim I, Nakamaru-Ogiso E, Wellen KE, Snyder NW, Garcia BA, Wallace DC. Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16028-16035.

Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function

Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function. Yucel N, Wang YX, Mai T, Porpiglia E, Lund PJ, Markov G, Garcia BA, Bendall SC, Angelo M, Blau HM. Cell Rep. 2019 Jun 25;27(13):3939-3955.e6.

Single Cell Proteomics to Study Embryonic Asymmetry in Xenopus laevis Embryos

Single Cell Proteomics to Study Embryonic Asymmetry in Xenopus laevis Embryos. Saha-Shah A, Esmaeili M, Sidoli S, Hwang H, Yang J, Klein PS, Garcia BA. Anal Chem. 2019 Jun 13. doi: 10.1021/acs.analchem.9b00327. [Epub ahead of print]

Histone H3K27 dimethyl loss is highly specific for malignant peripheral nerve sheath tumor and distinguishes true PRC2 loss from isolated H3K27 trimethyl loss

Histone H3K27 dimethyl loss is highly specific for malignant peripheral nerve sheath tumor and distinguishes true PRC2 loss from isolated H3K27 trimethyl loss. Marchione DM, Lisby A, Viaene AN, Santi M, Nasrallah M, Wang LP, Williams EA, Larque AB, Chebib I, Garcia BA, Wojcik JB. Mod Pathol. 2019 Jun 7. doi: 10.1038/s41379-019-0287-8. [Epub ahead of print]

Novel functions of the ubiquitin-independent proteasome system in regulating Xenopus germline development

Novel functions of the ubiquitin-independent proteasome system in regulating Xenopus germline development. Hwang H, Jin Z, Krishnamurthy VV, Saha A, Klein PS, Garcia B, Mei W, King ML, Zhang K, Yang J. Development. 2019 Apr 23;146(8).

The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells

The E3 ligase adaptor molecule SPOP regulates fetal hemoglobin levels in adult erythroid cells. Lan X, Khandros E, Huang P, Peslak SA, Bhardwaj SK, Grevet JD, Abdulmalik O, Wang H, Keller CA, Giardine B, Baeza J, Duffner ER, El Demerdash O, Wu XS, Vakoc CR, Garcia BA, Hardison RC, Shi J, Blobel GA. Blood Adv. 2019 May 28;3(10):1586-1597

One minute analysis of 200 histone post-translational modifications by direct injection mass spectrometry

One minute analysis of 200 histone post-translational modifications by direct injection mass spectrometry. Sidoli S, Kori Y, Lopes M, Yuan ZF, Kim HJ, Kulej K, Janssen KA, Agosto LM, Cunha JPC, Andrews AJ, Garcia BA. Genome Res. 2019 Jun;29(6):978-987.

PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism

PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Jain SU, Do TJ, Lund PJ, Rashoff AQ, Diehl KL, Cieslik M, Bajic A, Juretic N, Deshmukh S, Venneti S, Muir TW, Garcia BA, Jabado N, Lewis PW. Nat Commun. 2019 May 13;10(1):2146.

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas. Krug B, De Jay N, Harutyunyan AS, Deshmukh S, Marchione DM, Guilhamon P, Bertrand KC, Mikael LG, McConechy MK, Chen CCL, Khazaei S, Koncar RF, Agnihotri S, Faury D, Ellezam B, Weil AG, Ursini-Siegel J, De Carvalho DD, Dirks PB, Lewis PW, Salomoni P, Lupien M, Arrowsmith C, Lasko PF, Garcia BA, Kleinman CL, Jabado N, Mack SC. Cancer Cell. 2019 May 13;35(5):782-797.