Publications

A mass spectrometry-based assay using metabolic labeling to rapidly monitor chromatin accessibility of modified histone proteins

A mass spectrometry-based assay using metabolic labeling to rapidly monitor chromatin accessibility of modified histone proteins. Sidoli S, Lopes M, Lund PJ, Goldman N, Fasolino M, Coradin M, Kulej K, Bhanu NV, Vahedi G, Garcia BA. Sci Rep. 2019 Sep 20;9(1):13613.

Quantitation of Single and Combinatorial Histone Modifications by Integrated Chromatography of Bottom-up Peptides and Middle-down Polypeptide Tails

Quantitation of Single and Combinatorial Histone Modifications by Integrated Chromatography of Bottom-up Peptides and Middle-down Polypeptide Tails. Janssen KA, Coradin M, Lu C, Sidoli S, Garcia BA. J Am Soc Mass Spectrom. 2019 Sep 11. doi: 10.1007/s13361-019-02303-6. [Epub ahead of print]

Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma

Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma. Lee CH, Yu JR, Granat J, Saldaña-Meyer R, Andrade J, LeRoy G, Jin Y, Lund P, Stafford JM, Garcia BA, Ueberheide B, Reinberg D. Genes Dev. 2019 Sep 5. doi: 10.1101/gad.328773.119. [Epub ahead of print]

The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape

The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape. Weinberg DN, Papillon-Cavanagh S, Chen H, Yue Y, Chen X, Rajagopalan KN, Horth C, McGuire JT, Xu X, Nikbakht H, Lemiesz AE, Marchione DM, Marunde MR, Meiners MJ, Cheek MA, Keogh MC, Bareke E, Djedid A, Harutyunyan AS, Jabado N, Garcia BA, Li H, Allis CD, Majewski J, Lu C. Nature. 2019 Sep;573(7773):281-286.

PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation

PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation. Ren Z, Ahn JH, Liu H, Tsai YH, Bhanu NV, Koss B, Allison DF, Ma A, Storey AJ, Wang P, Mackintosh SG, Edmondson RD, Groen RWJ, Martens AC, Garcia BA, Tackett AJ, Jin J, Cai L, Zheng D, Wang GG. Blood. 2019 Aug 5. pii: blood.2019000578. doi: 10.1182/blood.2019000578. [Epub ahead of print]

Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy

Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy. Kopinski PK, Janssen KA, Schaefer PM, Trefely S, Perry CE, Potluri P, Tintos-Hernandez JA, Singh LN, Karch KR, Campbell SL, Doan MT, Jiang H, Nissim I, Nakamaru-Ogiso E, Wellen KE, Snyder NW, Garcia BA, Wallace DC. Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16028-16035.

Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function

Glucose Metabolism Drives Histone Acetylation Landscape Transitions that Dictate Muscle Stem Cell Function. Yucel N, Wang YX, Mai T, Porpiglia E, Lund PJ, Markov G, Garcia BA, Bendall SC, Angelo M, Blau HM. Cell Rep. 2019 Jun 25;27(13):3939-3955.e6.

Single Cell Proteomics to Study Embryonic Asymmetry in Xenopus laevis Embryos

Single Cell Proteomics to Study Embryonic Asymmetry in Xenopus laevis Embryos. Saha-Shah A, Esmaeili M, Sidoli S, Hwang H, Yang J, Klein PS, Garcia BA. Anal Chem. 2019 Jun 13. doi: 10.1021/acs.analchem.9b00327. [Epub ahead of print]

Histone H3K27 dimethyl loss is highly specific for malignant peripheral nerve sheath tumor and distinguishes true PRC2 loss from isolated H3K27 trimethyl loss

Histone H3K27 dimethyl loss is highly specific for malignant peripheral nerve sheath tumor and distinguishes true PRC2 loss from isolated H3K27 trimethyl loss. Marchione DM, Lisby A, Viaene AN, Santi M, Nasrallah M, Wang LP, Williams EA, Larque AB, Chebib I, Garcia BA, Wojcik JB. Mod Pathol. 2019 Jun 7. doi: 10.1038/s41379-019-0287-8. [Epub ahead of print]

Novel functions of the ubiquitin-independent proteasome system in regulating Xenopus germline development

Novel functions of the ubiquitin-independent proteasome system in regulating Xenopus germline development. Hwang H, Jin Z, Krishnamurthy VV, Saha A, Klein PS, Garcia B, Mei W, King ML, Zhang K, Yang J. Development. 2019 Apr 23;146(8).