Publications

HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies

HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies. Slaughter MJ, Shanle EK, Khan A, Chua KF, Hong T, Boxer LD, Allis CD, Josefowicz SZ, Garcia BA, Rothbart SB, Strahl BD, Davis IJ. Cell Rep. 2021 Jan 19;34(3):108638.

Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription

Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription. Kim ET, Dybas JM, Kulej K, Reyes ED, Price AM, Akhtar LN, Orr A, Garcia BA, Boutell C, Weitzman MD. Nat Microbiol. 2021 Feb;6(2):234-245.

Structure and noncanonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module

Li YC, Chao TC, Kim HJ, Cholko T, Chen SF, Li G, Snyder L, Nakanishi K, Chang CE, Murakami K, Garcia BA, Boyer TG, Tsai KL. Sci Adv. 2021 Jan 15;7(3):eabd4484.

Histone H3.3 beyond cancer: Germline mutations in Histone 3 Family 3A and 3B cause a previously unidentified neurodegenerative disorder in 46 patients.

Synthesis and Characterization of a Diazirine-Based Photolabel of the Nonanesthetic Fropofol

Synthesis and Characterization of a Diazirine-Based Photolabel of the Nonanesthetic Fropofol.  White ER, Leace DM, Bedell VM, Bhanu NV, Garcia BA, Dailey WP, Eckenhoff RG. ACS Chem Neurosci. 2020 Dec 23. doi: 10.1021/acschemneuro.0c00667.

Mechanistic insights into volatile anesthetic modulation of K2P channels

Mechanistic insights into volatile anesthetic modulation of K2P channels. Wague A, Joseph TT, Woll KA, Bu W, Vaidya KA, Bhanu NV, Garcia BA, Nimigean CM, Eckenhoff RG, Riegelhaupt PM. Elife. 2020 Dec 21;9:e59839. doi: 10.7554/eLife.59839. Online ahead of print.

H1 histones control the epigenetic landscape by local chromatin compaction

H1 histones control the epigenetic landscape by local chromatin compaction. Willcockson MA, Healton SE, Weiss CN, Bartholdy BA, Botbol Y, Mishra LN, Sidhwani DS, Wilson TJ, Pinto HB, Maron MI, Skalina KA, Toro LN, Zhao J, Lee CH, Hou H, Yusufova N, Meydan C, Osunsade A, David Y, Cesarman E, Melnick AM, Sidoli S, Garcia BA, Edelmann W, Macian F, Skoultchi AI. Nature. 2020 Dec 9. doi: 10.1038/s41586-020-3032-z. Online ahead of print.

Histone Purification Combined with High-Resolution Mass Spectrometry to Examine Histone Post-Translational Modifications and Histone Variants in Caenorhabditis elegans

TET2 chemically modifies tRNAs and regulates tRNA fragment levels

H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation

H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation. Harutyunyan AS, Chen H, Lu T, Horth C, Nikbakht H, Krug B, Russo C, Bareke E, Marchione DM, Coradin M, Garcia BA, Jabado N, Majewski J. Cell Rep. 2020 Nov 17;33(7):108390.