Publications

Accelerating the field of epigenetic histone modification through mass spectrometry-based approaches

Accelerating the field of epigenetic histone modification through mass spectrometry-based approaches. Lu C, Coradin M, Porter EG, Garcia BA. Mol Cell Proteomics. 2020 Nov 17:mcp.R120.002257.

Epigenetic and transcriptional control of the epidermal growth factor receptor (EGFR) regulates the tumor immune microenvironment in pancreatic cancer

Epigenetic and transcriptional control of the epidermal growth factor receptor (EGFR) regulates the tumor immune microenvironment in pancreatic cancer. Li J, Yuan S, Norgard RJ, Yan F, Sun YH, Kim IK, Merrell AJ, Sela Y, Jiang Y, Bhanu NV, Garcia BA, Vonderheide RH, Blanco A, Stanger BZ. Cancer Discov. 2020 Nov 6:CD-20-0519.

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression

Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.  Jain SU, Khazaei S, Marchione DM, Lundgren SM, Wang X, Weinberg DN, Deshmukh S, Juretic N, Lu C, Allis CD, Garcia BA, Jabado N, Lewis PW. Proc Natl Acad Sci U S A. 2020 Oct 16:202006076.

Histone Purification Combined with High-Resolution Mass Spectrometry to Examine Histone Post-Translational Modifications and Histone Variants in Caenorhabditis elegans

Histone Purification Combined with High-Resolution Mass Spectrometry to Examine Histone Post-Translational Modifications and Histone Variants in Caenorhabditis elegans.  Millan-Ariño L, Yuan ZF, Oomen ME, Brandenburg S, Chernobrovkin A, Salignon J, Körner L, Zubarev RA, Garcia BA, Riedel CG. Curr Protoc Protein Sci. 2020 Dec;102(1):e114.

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease.  Nativio R, Lan Y, Donahue G, Sidoli S, Berson A, Srinivasan AR, Shcherbakova O, Amlie-Wolf A, Nie J, Cui X, He C, Wang LS, Garcia BA, Trojanowski JQ, Bonini NM, Berger SL. Nat Genet. 2020 Oct;52(10):1024-1035.

SIRT1 is downregulated by autophagy in senescence and ageing

H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone

H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone. Khazaei S, De Jay N, Deshmukh S, Hendrikse LD, Jawhar W, Chen CC, Mikael LG, Faury D, Marchione DM, Lanoix J, Bonneil E, Ishii T, Jain SU, Rossokhata K, Sihota TS, Eveleigh R, Lisi V, Harutyunyan AS, Jung S, Karamchandani J, Dickson BC, Turcotte R, Wunder JS, Thibault P, Lewis PW, Garcia BA, Mack SC, Taylor MD, Garzia L, Kleinman CL, Jabado N. Cancer Discov. 2020 Sep 23:CD-20-0461. doi: 10.1158/2159-8290.CD-20-0461. Online ahead of print.

Lysine and Arginine Protein Post-translational Modifications by Enhanced DIA Libraries: Quantification in Murine Liver Disease

Lysine and Arginine Protein Post-translational Modifications by Enhanced DIA Libraries: Quantification in Murine Liver Disease.  Robinson AE, Binek A, Venkatraman V, Searle BC, Holewinski RJ, Rosenberger G, Parker SJ, Basisty N, Xie X, Lund PJ, Saxena G, Mato JM, Garcia BA, Schilling B, Lu SC, Van Eyk JE. J Proteome Res. 2020 Sep 23. doi: 10.1021/acs.jproteome.0c00685. Online ahead of print.

The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice

The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice.  Dobenecker MW, Marcello J, Becker A, Rudensky E, Bhanu NV, Carrol T, Garcia BA, Prinjha R, Yurchenko V, Tarakhovsky A. FEBS Lett. 2020 Aug 9. doi: 10.1002/1873-3468.13903. Online ahead of print.

The Viral Polymerase Complex Mediates the Interaction of Viral Ribonucleoprotein Complexes with Recycling Endosomes during Sendai Virus Assembly

The Viral Polymerase Complex Mediates the Interaction of Viral Ribonucleoprotein Complexes with Recycling Endosomes during Sendai Virus Assembly. Genoyer E, Kulej K, Hung CT, Thibault PA, Azarm K, Takimoto T, Garcia BA, Lee B, Lakdawala S, Weitzman MD, López CB. mBio. 2020 Aug 25;11(4):e02028-20. doi: 10.1128/mBio.02028-20.