Sex-specific epigenetic regulation of Cdk5 in stress and learning
Abstract: In a mouse model of traumatic memory, male mice recall fear-related memories better than female mice, according to a study in Biological Psychiatry. The difference between sexes was attributed to a gene important for creating fear memories and stress behavior, called cyclin dependent kinase 5 (Cdk5), which was naturally activated in male but not in female mice. The findings could help explain why fear and stress-related disorders affect men and women differently.