New Appointments to NIH Multidisciplinary Cardiovascular Training Grant

The following new appointments of 5 pre-doctoral and 3 postdoctoral fellows were made. An additional predoc and 3 postdocs were reappointed for their second year.

New PRE-doctoral appointments:

Janine Hall, will be working with Dr. Matthew Lazzara, Assistant Professor in the Chemical and Biomolecular Engineering Department. She will be working on the influence of extracellular matrix stiffness and composition upon the cellular response of cardiomyocytes to drugs specific for the ErbB family of receptor tyrosine kinases.

Stephanie Majkut, a student in the Department of Physics, will be working with Dr. Dennis Discher, a Professor of Mechanical Engineering. She will apply principles of embryogenesis to translational efforts in cardiogenesis using stem cells.

Joel Outten, will be working with Dr. Scott Diamond, Arthur E. Humphrey Professor, Department of Chemical and Biomolecular Engineering; and Director, Penn Center for Molecular Discovery. He will produce human platelets in vitro in sufficient conduct miRNA inhibitor and miRNA mimic high throughput screening to direct the differentiation of mesodermal lineage cells to hematopoietic stems cells. The long term goal is to produce human platelets in vitro in sufficient quantity to phenotype them in microfluidic assays of thrombosis.

David Slochower will be working with Dr. Paul Janmey, Professor of Physiology. He will study the physical-chemical effects of phospholipids (specifically PIP2) to control gating of Kir channels. This approach is in contrast to specific biochemical binding.

Shannon Telesco will be working with Dr. Ravi Radhakrishnan, Assistant Professor of Bioengineering. She will address the computational integration of receptor-mediated signaling with transcription factor regulatory networks, and ultimately gene expression in the context of ErbB4 receptor.

Reappointments:

Marie Murray, Predoc.

New POST-doctoral appointments:

Alexandra Cretu, Ph.D., earned her degree in Pathology from NYU School of Biomedical Sciences and has worked on transcript profiles to analyze the global effects of cryptic collagen epitopes. She will work under Dr. Richard Assoian, a Professor from the Department of Pharmacology, on ECM biology focusing on the role of vascular smooth muscle cells in arterial stiffness.

Jingyan Han, Ph.D., earned her degree in Pharmacology from the University of Illinois, Chicago, and has worked in endothelial biology, signaling, cytoskeleton, permeability and endocytosis. She will work under Dr. Vladimir Muzykantov, Associate Professor of Pharmacology and Medicine, on how endothelial phenotype and microenvironment such as fluid shear stress may affect endocytosis of nanocarriers targeted to PECAM-1 and ICAM-1.

Jonathan Vivente, Ph.D. earned his degree in Biomedical Engineering at the University of Pennsylvania working on fabricating devices ranging from mapping cardiac depolarization wavefronts in-vivo to mapping visual cortex in animals with unprecedented resolution over large areas. He will work under Dr. Brian Litt, Associate Professor , Department of Neurology on a new class of less invasive, implantable devices for high resolution mapping of cardiac dysrhythmias.

Reappointments:

Maria Carme Coll Ferrer, Ph.D., Postdoc.

Jordan Miller, Ph.D., Postdoc.

(Jennifer Clark, PH.D., reappointed March 2010), Postdoc.

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