Institute for Medicine and Engineering
1010 Vagelos Research Labs
3340 Smith Walk
Philadelphia, PA 19104-6383
My research interest is to understand how microenvironmental cues regulate stem/progenitor cell differentiation. Currently, my research is focusing on lung vascular SMC differentiation controlled by extracellular matrix properties: stiffness (biophysical property) and TGF-beta signaling (biochemical property). To examine this, I have utilized a decellularized lung scaffolds culture system and determine 3-D matrix signal on cell differentiation. In the long term, I hope that the information gathered using this approach will provide fundamental information necessary to understand the regeneration of the lung and to design more effective therapies.
Bibliography for Kaori Ihida-Stansbury
Talati M, Seeley E, Ihida-Stansbury K, Delisser H, McDonald H, Ye F, Zhang X, Shyr Y, Caprioli R, Meyrick B. Altered expression of nuclear and cytoplasmic histone H1 in pulmonary artery and pulmonary artery smooth muscle cells in patients with IPAH. Pulm Circ Jul 2 (3): 340-351.
Rehan VK, Sakurai R, Corral J, Krebs M, Ibe B, Ihida-Stansbury K, Torday JS. Antenatally administered PPAR-gamma agonist rosiglitazone prevents hyperoxia-induced neonatal rat lung injury. Am J Physiol Lung Cell Mol Physiol Nov 299 (5): L672-680.
Kashio N, Tsuyama S, Ihida K, Murata F. Cationic colloidal gold–a probe for light- and electron-microscopic characterization of acidic glycoconjugates using poly-L-lysine gold complex. Histochem J Jul 1992; 24 (7): 419-430.
Yada T, Sakurada M, Nakata M, Ihida K, Yaekura K, Shioda S, Kikuchi M. Current status of PACAP as a regulator of insulin secretion in pancreatic islets. Ann N Y Acad Sci Dec 26 1996; 805 329-340; discussion 341-322.
Huang Z, Wang D, Ihida-Stansbury K, Jones PL, Martin JF. Defective pulmonary vascular remodeling in Smad8 mutant mice. Hum Mol Genet Aug 1 2009; 18 (15): 2791-2801.
Sisbarro L, Ihida-Stansbury K, Stevens T, Bauer N, McMurtry I, Jones PL. The extracellular matrix microenvironment specifies pulmonary endothelial cell identity: roles of tenascin-C and RhoA. Chest Dec 2005; 128 (6 Suppl): 564S.
Ihida K, Suganuma T, Tsuyama S, Murata F. Glycoconjugate histochemistry of the rat fundic gland using Griffonia simplicifolia agglutinin-II during the development. Am J Anat Jul 1988; 182 (3): 250-256.
Stan RV, Roberts WG, Predescu D, Ihida K, Saucan L, Ghitescu L, Palade GE. Immunoisolation and partial characterization of endothelial plasmalemmal vesicles (caveolae). Mol Biol Cell Apr 1997; 8 (4): 595-605.
Torday JS, Ihida-Stansbury K, Rehan VK. Leptin stimulates Xenopus lung development: evolution in a dish. Evol Dev Mar-Apr 2009; 11 (2): 219-224.
Kashio N, Tsuyama S, Ihida K, Murata F. [Light and electron microscopic demonstration of acidic glycoconjugates by means of postembedding staining procedures using cationic colloidal gold]. Kaibogaku Zasshi Feb 1993; 68 (1): 91-103.
Goncharov DA, Kudryashova TV, Ziai H, Ihida-Stansbury K, Delisser H, Krymskaya VP, Tuder RM, Kawut SM, Goncharova EA. Mammalian Target of Rapamycin Complex 2 (mTORC2) Coordinates Pulmonary Artery Smooth Muscle Cell Metabolism, Proliferation, and Survival in Pulmonary Arterial Hypertension. Circulation Feb 25 129 (8): 864-874.
Wang M, Ihida-Stansbury K, Kothapalli D, Tamby MC, Yu Z, Chen L, Grant G, Cheng Y, Lawson JA, Assoian RK, Jones PL, Fitzgerald GA. Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury. Circulation Feb 15 123 (6): 631-639.
Krymskaya VP, Snow J, Cesarone G, Khavin I, Goncharov DA, Lim PN, Veasey SC, Ihida-Stansbury K, Jones PL, Goncharova EA. mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia. Faseb J Jun 25 (6): 1922-1933.
Murata F, Suganuma T, Tsuyama S, Ihida K. [Mucous neck cells: proposal that mucous neck cells are the precursor cells of the chief cells–studies based on glycoconjugate cytochemistry]. Kaibogaku Zasshi Feb 1988; 63 (1): 12-19.
Yu Z, Ricciotti E, Miwa T, Liu S, Ihida-Stansbury K, Landersberg G, Jones PL, Scalia R, Song WC, Assoian RK, FitzGerald GA. Myeloid cell 5-lipoxygenase activating protein modulates the response to vascular injury. Circ Res Feb 1 112 (3): 432-440.
Ihida-Stansbury K, McKean DM, Gebb SA, Martin JF, Stevens T, Nemenoff R, Akeson A, Vaughn J, Jones PL. Paired-related homeobox gene Prx1 is required for pulmonary vascular development. Circ Res Jun 11 2004; 94 (11): 1507-1514.
Yada T, Sakurada M, Ihida K, Nakata M, Murata F, Arimura A, Kikuchi M. Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells. J Biol Chem Jan 14 1994; 269 (2): 1290-1293.
Ihida K, Predescu D, Czekay RP, Palade GE. Platelet activating factor receptor (PAF-R) is found in a large endosomal compartment in human umbilical vein endothelial cells. J Cell Sci Feb 1999; 112 ( Pt 3) 285-295.
Zhang M, Ihida-Stansbury K, Van der Spiegel J, Engheta N. Polarization-based non-staining cell detection. Opt Express Nov 5 20 (23): 25378-25390.
Reichert M, Takano S, von Burstin J, Kim SB, Lee JS, Ihida-Stansbury K, Hahn C, Heeg S, Schneider G, Rhim AD, Stanger BZ, Rustgi AK. The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis. Genes Dev Feb 1 27 (3): 288-300.
Ihida-Stansbury K, McKean DM, Gebb SA, Martin JF, Stevens T, Nemenoff R, Vaughn J, Lane K, Loyd J, Wheeler L, Morrell NW, Ivy D, Jones PL. Regulation and functions of the paired-related homeobox gene PRX1 in pulmonary vascular development and disease. Chest Dec 2005; 128 (6 Suppl): 591S.
Chapados R, Abe K, Ihida-Stansbury K, McKean D, Gates AT, Kern M, Merklinger S, Elliott J, Plant A, Shimokawa H, Jones PL. ROCK controls matrix synthesis in vascular smooth muscle cells: coupling vasoconstriction to vascular remodeling. Circ Res Oct 13 2006; 99 (8): 837-844.
Suganuma T, Muramatsu H, Muramatsu T, Ihida K, Kawano J, Murata F. Subcellular localization of N-acetylglucosaminide beta 1—-4 galactosyltransferase revealed by immunoelectron microscopy. J Histochem Cytochem Mar 1991; 39 (3): 299-309.
Ihida K, Tsuyama S, Kashio N, Murata F. Subcompartment sugar residues of gastric surface mucous cells studied with labeled lectins. Histochemistry 1991; 95 (4): 329-335.
Murata F, Tsuyama S, Ihida K, Kashio N, Kawano M, Li ZZ. Sulfated glycoconjugates demonstrated in combination with high iron diamine thiocarbohydrazide-silver proteinate and silver acetate physical development. J Electron Microsc (Tokyo) Feb 1992; 41 (1): 14-20.
Ihida-Stansbury K, McKean DM, Lane KB, Loyd JE, Wheeler LA, Morrell NW, Jones PL. Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol Oct 2006; 291 (4): L694-702.
Predescu D, Ihida K, Predescu S, Palade GE. The vascular distribution of the platelet-activating factor receptor. Eur J Cell Biol Jan 1996; 69 (1): 86-98.
Cohen ED, Ihida-Stansbury K, Lu MM, Panettieri RA, Jones PL, Morrisey EE. Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. J Clin Invest Sep 2009; 119 (9): 2538-2549.