Robinette Foundation Professor of Cardiovascular Medicine, Professor of Pathology and Laboratory Medicine, and Professor of
Professor, IME & Department of Pathology and Laboratory Medicine
1010 Vagelos Research Labs
3340 Smith Walk
Philadelphia, PA 19104-6383
(215) 898-4647, phone
(215) 573-6815, fax
B.Sc. (Chemistry/Ag. Biochemistry (w/Hons.))
University of Newcastle-upon-Tyne, 1969.
University of Victoria, B.C., Canada, 1972.
Ph.D. (Experimental Pathology)
University of Cambridge, 1975.
M.A. (Honoris causa)
University of Pennsylvania, 1996.
Sc.D. (Higher Doctorate)
University of Cambridge, 2015.
Honors and Awards
Special Dean’s Award – School of Medicine – 2010, Senior Research Scientist Award – American Heart Association – 2004
Peter’s bioengineering research is directed at the fundamental mechanisms underlying cardiovascular diseases, in particular, the cellular, subcellular, and molecular pathophysiology of endothelial cells and the role that hemodynamics plays in the epigenetic regulation of molecular mechanotransduction, gene and protein expression an functional consequences in health and disease. Peter and his lab use computational models, experimental in vivo and in vitro flow devices and a full range of cell and molecular biology approaches.
Molecular mechanisms of cardiovascular diseases, particularly arterial biology and pathology (atherosclerosis). Mechanisms of interaction of hemodynamic forces with the vascular endothelium and vascular cell-cell interactions. Systems biology of the endothelium. Experimental approaches ranging from cell and molecular biology, membrane biophysics, to biomechanics and computational fluid dynamics. Endocardial endothelium and 4D-flow MRI.
Davies P.F.: In: LabStudio: Design Research Between Architecture & Biology. Sabin J and Jones P. Pub: Routledge / Taylor and Francis (2016). In Press. Routledge / Taylor and Francis In Press, 2016.
Sweet DT, Jiménez JM, Chang J, Hess PR, Mericko-Ishizuka P, Fu J, Xia L, Davies PF, Kahn ML.: Lymph flow regulates collecting lymphatic vessel maturation in vivo. J. Clin Invest. 125: 2995-3007, August 2015.
Han J, Shuvaev VV, Davies PF, Eckmann DM, Muro S, Muzykantov VR. : Flow shear stress differentially regulates endothelial uptake of nanocarriers targeted to distinct epitopes of PECAM-1. J Controlled Release 210: 39-47, July 2015.
Jiang, Y-Z, Manduchi, E, Stoeckert CJ, Davies PF.: Arterial endothelial methylome: Differential DNA methylation in athero-susceptible disturbed flow regions in vivo. BMC Genomics 16: 506, July 2015.
Chacko A-M, Han J, Zern BJ, Greineder C, Mikitsch JL, Nayak M, Menon D, Poncz M, Johnston I, Eckman D, Davies PF, Muzykantov VR.: Collaborative enhancement of endothelial nanocarrier targeting by modulating PECAM-1/CD31 epitope engagement. Am. Chem. Soc. Nano. 9(7): 6785-6793, July 2015.
Jiang Y-Z, Manduchi E, Jimenez JM, Davies PF. : Endothelial epigenetics in biomechanical stress: Disturbed flow-mediated epigenomic plasticity in vivo and in vitro. Arterioscler Thromb Vasc Biol 35: 1317-1326, June 2015.
Kwak, B., Back M., Bochaton-Piallat, M.L., Caligiuri, G., Daemen, M., Davies, P.F., Hoefer, I., Holvoet, P., Krams, R., Monaco, C., Virmani, R., Weber, C., Wentzel Y., Evans, P.: Biomechanical factors in atherosclerosis – Mechanisms and implications. European Heart Journal. European Society Cardiology, 35(43): 3013-3020, Sept 2014.
Jiang YZ, Jiménez JM, Ou K, McCormick ME, Zhang LD, Davies PF.: Hemodynamic disturbed flow induces differential DNA methylation of endothelial kruppel-like factor 4 promoter in vitro and in vivo. Circulation Research 115:((1)): 32-43, June 2014.
Davies PF, Manduchi E, Stoeckert CJ, Jimenez JM, Jiang, Y-Z : Emerging topic: Flow-related epigenetic regulation of endothelial phenotype through DNA methylation. Vascular Pharmacology 62: 88-93, March 2014.
Jimenez, J.M., Prasad, V., Yu, M., Kampmeyer, C., Kaakour, A-H., Wang, P., Maloney, S.F., Wright, N., Johnston, I., Jiang, Y-Z., Davies P.F. : Macro and microscale variables regulate coronary stent hemodynamics, fibrin deposition and thrombomodulin expression. J. Royal Society Interface. The Royal Society, London, 11(94):20131079., February 2014.