Juan M. Jiménez, a Research Associate faculty member in the Department of Pathology and Laboratory Medicine at the Perelman School of Medicine, is a trained fluid dynamics engineer. His research interests are in the area of biofluids, combining fluid dynamics and vascular biology concepts to study the development and progression of atherosclerosis in the cardiovascular system. Interestingly, at a site where a stent is deployed to treat atherosclerotic lesions, the stent design can play a major role in the newly modified flow field and can affect the development of neoatherosclerosis and thrombosis. My current research focuses on optimizing stent strut design for favorable vessel healing, improving endothelialization and decreasing in-stent thrombosis in order to decrease morbidity and mortality associated with stents. Another area of research interest involves studying how different blood flow fields can affect vascular wound healing post-injury. In addition, I am interested in understanding the effect of local fluid transport in the development of atherosclerotic lesions. In general, the distribution of cholesterol in the blood is homogeneous while atherosclerotic lesions develop heterogeneously within the cardiovascular system. My hypothesis is that the development of atherosclerotic lesions is affected by the local blood flow and ensuing fluid transport effects of this flow field.
Davies PF, Manduchi E, Jiménez JM, Stoeckert CJ, Jiang Y. Flow-mediated endothelial epigenomics and atherosusceptibility: DNA methylation plasticity. Arterioscl. Thromb. Vasc. Biol. 2014. In Press
Davies PF, Manduchi E, Stoeckert CJ, Jiménez JM, Jiang Y. Emerging topic: flow-related epigenetic regulation of the atherosusceptible endothelial phenotype through DNA methylation. Vascul Pharmacol, 62, 88-93, 2014.
Jiang Y, Jiménez JM, Ou K, McCormick ME, Zhang L, Davies PF. Hemodynamic disturbed flow induces differential DNA methylation of endothelial KLF4 promoter in vitro and in vivo. Circ. Res., 115:32-43, 2014.
Jiménez JM, Prasad V, Yu MD, Kampmeyer CP, Kaakour AH, Wang PJ, Maloney SF, Wright N, Johnston I, Jiang YZ, Davies PF. Macro- and microscale variables regulate stent haemodynamics, fibrin deposition and thrombomodulin expression. Journal of the Royal Society, Interface / the Royal Society 2014; 11 (94): 20131079.
McIntire LV, Jiménez JM, Eskin SG, Davies PF. “Hemostasis and Thrombosis: Basic Principles and Clinical Practice,” Rheology and Vessel Wall Stress. 2012, p. 516-535.
Jiménez JM, Smits AJ. Tip and Junction Vortices Generated by the Sail of a Yawed Submarine Model at Low Reynolds Numbers. Journal of Fluids Engineering-Transactions of the Asme Mar 2011; 133 (3): -.
Jiménez JM, Reynolds RT, Smits AJ. The Effects of Fins on the Intermediate Wake of a Submarine Model. Journal of Fluids Engineering-Transactions of the ASME Mar 2010; 132 (3):
Jiménez JM, Hultmark M, Smits AJ. The intermediate wake of a body of revolution at high Reynolds numbers. Journal of Fluid Mechanics Sep 2010; 659 516-539.
Jiménez JM, Davies PF. “Design Implications for Endovascular Stents and the Endothelium,” Hemodynamics and Mechanobiology of Endothelium. 2010, p. 291-312.
Jiménez JM, Davies PF. Hemodynamically driven stent strut design. Ann Biomed Eng Aug 2009; 37 (8): 1483-1494.
Jiménez JM, Buchholz JHJ, Staples AE, Allen JJ, Smits AJ. Flapping Membranes for Thrust Production. IUTAM Symposium on Integrated Modeling of Fully Coupled Fluid Structure Interactions Using Analysis, Computations and Experiments, 2003