Welcome to the Penn Epigenetics Institute

Research

Intracytoplasmic Sperm Injection

Colin Conine Lab
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Publication

February 2020 Immunity Cover

Golnaz Vahedi Lab
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Video

Get to Know the Conine Lab

Conine Lab

The Conine lab studies RNA in sperm and its role in epigenetic inheritance. Get to know them here!

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Video

How the 3D organization of DNA controls cell identity

Jain Lab

The Jain lab is interested in stem cell biology, heart development, and genome organization. They have a passion for explaining science to the general public – check out their latest video!

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Welcome from the Director

An epigenetic trait is defined as a stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence. At the Penn Epigenetics Institute, our group of talented faculty, trainees, and staff investigate all aspects of epigenetics – from its role in cancer, development, and immunity to how it affects social structures and the way our brains function. Our goal is to advance basic and applied research in chromatin biology and epigenetics, building on current interest both in mechanisms underlying epigenetic regulation and in unraveling genome-wide chromatin patterns.

The Institute was established in 2017 to bring together the epigenetics community at Penn, providing a space where scientific endeavors could flourish. With over 38 core labs, the Institute has created an unparalleled environment for collaboration and cutting-edge research, which is often published in top-tier journals. Faculty regularly collaborate with clinical investigators to conduct translational research that advances medical breakthroughs. Our reach goes beyond the Penn community, with participation from labs at CHOP, Wistar, Jefferson, Fox Chase, Drexel, and Temple. We engage with nationally and internationally renowned scientists at our monthly seminars and annual symposia. We continue to build the Institute by recruiting new faculty, engaging in large group projects that lead to new research grant opportunities, and establishing state-of-the-art technology cores.

To learn more about the Penn Epigenetics Institute, explore our website!

Congratulations to Phillip Wulfridge!

Phillip Wulfridge, PhD, a postdoc in the Sarma lab, was recently awarded an NRSA F32 fellowship to study epigenetic mechanisms of ATRX in genome regulation. The grant was co-mentored by Marisa Bartolomei. Congratulations Phillip!

News

October 14, 2021

Hao Wu to Serve as Principal Investigator for NIH’s Impact of Genomic Variation on Function (IGVF) Project

The NIH has selected Penn Medicine as one of 25 award recipients across 30 sites in the United States to serve as Impact of Genomic Variation on Function (IGVF) investigators,…

October 06, 2021

Liling Wan receives NIH DP2 New Innovator Award

Liling Wan was recently awarded an NIH DP2 New Innovator Award for her work titled Illuminating Transcriptional Condensates Using an Integrated Approach. You can learn more here. Congratulations Liling!

October 06, 2021

Erica Korb receives NIH DP2 New Innovator Award

Erica Korb was recently awarded an NIH DP2 New Innovator Award for her work titled The Epigenetic Encoding of Learning and Memory. You can learn more here. Congratulations Erica!

October 05, 2021

Jennifer Phillips-Cremins receives NIH Director’s Pioneer Award

Jennifer Phillips-Cremins was recently awarded an NIH Director’s Pioneer Award for her work titled From 3D Genomes to Neural Connectomes: Higher-Order Chromatin Mechanisms Encoding Long-Term Memory. You can read more…

September 27, 2021

Phillip Wulfridge (Sarma lab) awarded NSRA F32 Fellowship

Phillip Wulfridge (post doc in the Sarma lab, grant co-mentored by M. Bartolomei) was recently awarded an NRSA F32 fellowship to study epigenetic mechanisms of ATRX in genome regulation. Congratulations…

September 15, 2021

Emily Pickup joins Phillips-Cremins lab

Emily Pickup has joined Jennifer Phillips-Cremins’s lab as a Neuroscience graduate student. Welcome Emily!

September 07, 2021

Ashley Karnay (Jain lab) awarded F31 grant

Ashley Karnay (CAMB graduate student in the Jain lab) was recently awarded an F31 for her proposal entitled “Deciphering the Molecular Orchestrators of Heterochromatin-Lamina Interactions at the Nuclear Periphery.” Her…

September 03, 2021

Harshini Chandrashekar (Phillips-Cremins lab) passes qualifying exam

Congratulations to Harshini Chandrashekar (Bioengineering graduate student) from the Phillips-Cremins lab for passing her qualifying exam!

September 02, 2021

Thomas Malachowski (Phillips-Cremins lab) passes qualifying exam

Congratulations to Thomas Malachowski (Bioengineering graduate student) from the Phillips-Cremins lab for passing his qualifying exam!

September 01, 2021

Rohan Patel joins Phillips-Cremins lab

Rohan Patel has joined Jennifer Phillips-Cremins’s lab as a Bioengineering graduate student. Welcome Rohan!

Featured Labs

Conine Lab

The Conine lab studies RNA in sperm and its role in epigenetic inheritance. Get to know them here!

Anguera Lab

The Anguera lab studies X-inactivation and its role in immunity. Get to know them here!

Black Lab

The Black lab studies the most pressing questions in chromosome biology. Get to know them here!

Publication Highlights

From Rahul Kohli Lab
From Junwei Shi Lab

Berríos KN, Evitt NH, DeWeerd RA, Ren D, Luo M, Barka A, Wang T, Bartman CR, Lan Y, Green AM, Shi J, Kohli RM. Controllable genome editing with split-engineered base editors. Nat Chem Biol. 2021 Oct 18. doi: 10.1038/s41589-021-00880-w. Epub ahead of print. PMID: 34663942.

From Gerd Blobel Lab
From Rajan Jain Lab
From Eric Joyce Lab
From Golnaz Vahedi Lab

Linares-Saldana R, Kim W, Bolar NA, Zhang H, Koch-Bojalad BA, Yoon S, Shah PP, Karnay A, Park DS, Luppino JM, Nguyen SC, Padmanabhan A, Smith CL, Poleshko A, Wang Q, Li L, Srivastava D, Vahedi G, Eom GH, Blobel GA, Joyce EF, Jain R. BRD4 orchestrates genome folding to promote neural crest differentiation. Nat Genet. 2021 Oct;53(10):1480-1492. doi: 10.1038/s41588-021-00934-8. Epub 2021 Oct 5. PMID: 34611363.

From Gerd Blobel Lab

Blobel GA, Higgs DR, Mitchell JA, Notani D, Young RA. Testing the super-enhancer concept. Nat Rev Genet. 2021 Sep 3. doi: 10.1038/s41576-021-00398-w. Epub ahead of print. PMID: 34480110.

From Gerd Blobel Lab

Zhang H, Lam J, Zhang D, Lan Y, Vermunt MW, Keller CA, Giardine B, Hardison RC, Blobel GA. Nat Commun. 2021;12:5157. doi: 10.1038/s41467-021-25418-5.

From R. Babak Faryabi Lab

Schwartz GW, Zhou Y, Petrovic J, Pear WS, Faryabi RB. Cell Rep. 2021;36(8):109575. doi: 10.1016/j.celrep.2021.109575. PMID: 34433064.

Videos

Contact the Institute

Epigenetics Institute
Department of Cell and Developmental Biology
9th Floor, Smilow Center for Translational Research
3400 Civic Center Blvd
Philadelphia, PA 19104
T: 215-573-5858
pennepigenetics@pennmedicine.upenn.edu

 

Sophia Castro-Anderson
Administrator
andes@pennmedicine.upenn.edu

Samantha Falk
Social Media Coordinator
samfalk@pennmedicine.upenn.edu