Our lab focuses on mechanisms that regulate gene expression with a special emphasis on how the DNA-packaging structure of chromatin is manipulated during genomic processes. Our findings inform the study of cancer and other diseases, and ultimately drug discovery.

Meet Our Team

November 06, 2020
Interested in learning more about the interactions between metabolism and epigenetics? Check out our perspective written by Gabor Egervari and Karl Glastad in Science Magazine.
October 26, 2020
A lovely video from Being Patient on epigenetics and Alzheimer’s disease with our former post-doc Raffaella Nativio, now at Imperial College in London: Decoding the Epigenetics of Alzheimer’s | Brain Talks | Being Patient Al…
October 15, 2020
A great feature on our post-doc Khoa Tran, co-founder of JKX Comics in the Penn Gazette. Khoa describes his passion project of using comics to help with science education!
October 09, 2020
Cool write-up on our unique project with the Liberty  Science  Center on leaf cutter ants! Another great Berger  Lab collaboration led by Michael  Gilbert, Cristina Brady, and Balint Kacsoh!
September 28, 2020
Online today: our paper demonstrating Sirt1 is downregulated by autophagy in senescence and aging by Caiyue Xu and Lu Wang in @NatureCellBio. Exciting mechanism/potential strategy to promote productive aging.
September 28, 2020
Check out our latest work on epigenetic alterations in Alzheimer’s disease by Raffaella Nativio, out now in @NatureGenet. A fantastic, multi-omic, collaborative effort utilizing human tissues and fruit fly models @PennEpiInst @PennCDB@PennGenetics@PennBiology
September 23, 2020
Join us for our next symposium on Tuesday 10/6 for “Senescence and aging: chromatin gone awry” Chaired by @senergystic! Speakers Drs. Shelley Berger, Isabel Beerman, John Sedivy, and Alejandro Ocampo!
September 15, 2020
#CHSLEPICH20 kicked off this morning! Shelley presented some of the lab’s work utilizing multiple systems to study epigenetic mechanisms regulating stress pathways. We are sad to miss seeing everyone in person, but we are looking forward to a great week of talks!
Shelley L. Berger, Ph.D.

Shelley Berger, Ph.D., is the Daniel S. Och University Professor at University of Pennsylvania (Penn) and is a faculty member in the Cell & Developmental Biology Department and the Genetics Department in the Perelman School of Medicine, as well as the Biology Department in the School of Arts and Sciences. Dr. Berger also serves as Director of the Epigenetics Institute at Penn School of Medicine. Dr. Berger is an elected member of the National Academy of Science, the National Academy of Medicine, the American Academy of Arts and Sciences, and the American Association for Advancement of Science.

Learn More About Shelley L. Berger, Ph.D.

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