Our lab focuses on mechanisms that regulate gene expression with a special emphasis on how the DNA-packaging structure of chromatin is manipulated during genomic processes. Our findings inform the study of cancer and other diseases, and ultimately drug discovery.

Meet Our Team

May 17, 2021
Our speckles paper led by Kate Alexander is now in print! We think it’s specktacular!
April 19, 2021
Congrats to our graduate student Michael Gilbert for receiving a fellowship from NIA to study the proteomic landscape that defines social behavior in Camponotus floridanus! Also co-mentored by Ben Garcia.
April 05, 2021
Excited to share our research highlighting a new role for the transcription factor p53 in re-locating its target genes within the nucleus in relation to nuclear speckles, phase-separated nuclear bodies, that boost gene expression of select target genes.
April 05, 2021
Mysterious “nuclear speckle” structures inside cells enhance gene activity and may help block cancers:
April 05, 2021
This work was led by post-doc Kate Alexander, who had a spectacular time working on this project! A huge thank you to our wonderful collaborators: Arjun Raj, Andrew Belmont, Eric Joyce, and Shawn Little.
March 31, 2021
Congratulations to Shelley L. Berger, Ph.D., and M. Celeste Simon, Ph.D., for being named 2021 fellows of the American Association for Cancer Research, recognized for their contributions that have propelled innovation and progress against cancer.
March 23, 2021
Congratulations to our postdoc Paula Agudelo Garcia for receiving an NRSA F32 Fellowship to study how metabolism regulates the epigenetic landscape in T cell exhaustion! A very exciting grant co-mentored by John Wherry.
March 12, 2021
Our postdoc Lacey Luense wrote a preview for this month’s Cell Host and Microbe on recent work by Deborah Bourchis and colleagues on m6A methylation of ERVKs. Also, check out the latest genre-bending artwork from our postdoc Karl Glastad.
Shelley L. Berger, Ph.D.

Shelley Berger, Ph.D., is the Daniel S. Och University Professor at University of Pennsylvania (Penn) and is a faculty member in the Cell & Developmental Biology Department and the Genetics Department in the Perelman School of Medicine, as well as the Biology Department in the School of Arts and Sciences. Dr. Berger also serves as Director of the Epigenetics Institute at Penn School of Medicine. Dr. Berger is an elected member of the National Academy of Science, the National Academy of Medicine, the American Academy of Arts and Sciences, and the American Association for Advancement of Science.

Learn More About Shelley L. Berger, Ph.D.

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