Welcome to the Penn Epigenetics Institute


Intracytoplasmic Sperm Injection

Colin Conine Lab
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February 2020 Immunity Cover

Golnaz Vahedi Lab
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Drosophilia ovary with whole chromosome oligopaints

Eric Joyce Lab
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April 8th, 2021

Elena Ezhkova, PhD (Professor, Ichan School of Medicine at Mount Sinai) & Shaun Egolf (CAMB graduate student, Capell lab)



Get to Know the Conine Lab

Conine Lab

The Conine lab studies RNA in sperm and its role in epigenetic inheritance. Get to know them here!


Welcome from the Director

An epigenetic trait is defined as a stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence. At the Penn Epigenetics Institute, our group of talented faculty, trainees, and staff investigate all aspects of epigenetics – from its role in cancer, development, and immunity to how it affects social structures and the way our brains function. Our goal is to advance basic and applied research in chromatin biology and epigenetics, building on current interest both in mechanisms underlying epigenetic regulation and in unraveling genome-wide chromatin patterns.

The Institute was established in 2017 to bring together the epigenetics community at Penn, providing a space where scientific endeavors could flourish. With over 38 core labs, the Institute has created an unparalleled environment for collaboration and cutting-edge research, which is often published in top-tier journals. Faculty regularly collaborate with clinical investigators to conduct translational research that advances medical breakthroughs. Our reach goes beyond the Penn community, with participation from labs at CHOP, Wistar, Jefferson, Fox Chase, Drexel, and Temple. We engage with nationally and internationally renowned scientists at our monthly seminars and annual symposia. We continue to build the Institute by recruiting new faculty, engaging in large group projects that lead to new research grant opportunities, and establishing state-of-the-art technology cores.

To learn more about the Penn Epigenetics Institute, explore our website!

Congratulations to Wonho Kim!

Wonho Kim (postdoc in the Jain lab) is the recipient of an AHA Postdoctoral Fellowship for his grant entitled BRD4-mediated genome folding in smooth muscle cell differentiation. Congratulations Wonho!


April 06, 2021

Rajan Jain Receives 2021 Seldin~Smith Award for Pioneering Research

Rajan Jain, MD is the recipient of the 2021 Donald Seldin~Holly Smith Award for Pioneering Research from the American Society for Clinical Investigation (ASCI). Dr. Jain will receive an unrestricted…

April 02, 2021

Paula Agudelo Garcia (Berger lab) Receives NRSA F32 Fellowship

Paula Agudelo Garcia (postdoc in the Berger lab, grant co-mentored by E. John Wherry) is the recipient of an NRSA F32 Fellowship to study how metabolism regulates the epigenetic landscape…

March 28, 2021

Irfan Asangani receives Department of Defense Idea Expansion Award

Irfan Asangani was recently awarded a Department of Defense Idea Expansion Award (2021-2024) for his proposal entitled “PP2A activation as a therapy for AR addicted refractory castration-resistant prostate cancer.” Congratulations…

March 28, 2021

Irfan Asangani receives Conquer Cancer Now Award

Irfan Asangani was recently awarded the Conquer Cancer Now Award 2020-2022 from Concern Foundation for his grant entitled “Towards understanding and targeting transcriptional addiction in advanced prostate cancer.” Read more…

March 28, 2021

Kiara Rodriguez-Acevedo (Korb lab) awarded NSF fellowship

Kiara Rodriguez-Acevedo, who attended the SUIP program last summer in the Korb lab and will be joining Penn as a CAMB graduate student this fall, was awarded the NSF graduate…

February 18, 2021

Michael Guo (Cremins lab) awarded an NIH R25 physician-scientist research fellowship

Dr. Michael Guo, postdoctoral research fellow in the Cremins lab, is awarded an NIH R25 physician-scientist research fellowship. Congratulations!

February 12, 2021

Gabor Egervari (Berger lab) receives K99/R00 transition award

Gabor Egervari, a postdoc in the Berger lab, is the recipient of a K99/R00 transition award from the National Institute on Alcohol Abuse and Alcoholism to study how alcohol affects…

February 12, 2021

Balint Kacsoh (Berger lab) wins second place in the annual postdoc symposium poster presentation

Balint Kacsoh, a postdoc in the Berger lab, took second place in the Annual Biomedical Postdoctoral Symposium poster presentation contest. Congratulations Balint!

January 19, 2021

Photo taken by Balint Kacsoh (Berger lab) featured on cover of Canadian Journal of Zoology

The January 2021 edition of the Canadian Journal of Zoology features a photo of a leaf cutter ant taken by Balint Kacsoh, a postdoc in the Berger lab, on the…

January 05, 2021

Marco Carpenter (Heller lab) receives Postdoctoral Research Fellowship for Academic Diversity

Marco Carpenter, a postdoctoral fellow who will be joining the Heller lab in June 2021, received a Postdoctoral Research Fellowship for Academic Diversity at the Children’s Hospital of Philadelphia. Welcome…

Featured Labs

Conine Lab

The Conine lab studies RNA in sperm and its role in epigenetic inheritance. Get to know them here!

Anguera Lab

The Anguera lab studies X-inactivation and its role in immunity. Get to know them here!

Garcia Lab

The Garcia lab uses quantitative mass spectrometry-based proteomics to study epigenetics. Get to know them here!

Publication Highlights

From Irfan Asangani Lab

Deng Q, Rasool RU, Russell RM, Natesan R, Asangani IA. iScience. 2021 Mar 19;24(3):102254. doi: 10.1016/j.isci.2021.102254. Epub 2021 Mar 1. PMID: 33681723

From Marisa Bartolomei Lab
From Roberto Bonasio Lab
From Rahul Kohli Lab

Caldwell BA, Liu MY, Prasasya RD, Wang T, DeNizio JE, Leu NA, Amoh NYA, Krapp C, Lan Y, Shields EJ, Bonasio R, Lengner CJ, Kohli RM, Bartolomei MS. Mol Cell. 2021 Feb 18;81(4):859-869.e8. doi: 10.1016/j.molcel.2020.11.045. Epub 2020 Dec 21. PMID: 33352108

From Rajan Jain Lab

Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R. Cell Stem Cell. 2021 Jan 26:S1934-5909(20)30600-7. doi: 10.1016/j.stem.2020.12.016. Epub ahead of print. PMID: 33529599

From Gerd Blobel Lab
From Melike Lakadamyali Lab

Luan J, Xiang G, Gómez-García PA, Tome JM, Zhang Z, Vermunt MW, Zhang H, Huang A, Keller CA, Giardine BM, Zhang Y, Lan Y, Lis JT, Lakadamyali M, Hardison RC, Blobel GA. Cell Rep. 2021 Feb 23;34(8):108783. doi: 10.1016/j.celrep.2021.108783. PMID: 33626344

From Klaus Kaestner Lab
From Ken Zaret Lab

Reizel Y, Morgan A, Gao L, Schug J, Mukherjee S, García MF, Donahue G, Baur JA, Zaret KS, Kaestner KH. Dev Cell. 2021 Feb 24:S1534-5807(21)00116-7. doi: 10.1016/j.devcel.2021.02.005. Epub ahead of print. PMID: 33636105


Contact the Institute

Epigenetics Institute
Department of Cell and Developmental Biology
9th Floor, Smilow Center for Translational Research
3400 Civic Center Blvd
Philadelphia, PA 19104

Sophia Castro-Anderson
T: 215-573-5858

Samantha Falk
Social Media Coordinator