Welcome to the Penn Epigenetics Institute

Events

Epigenetics Institute Research in Progress Interest Group Meeting

Thursday, April 25, 2019 from 4-5:30PM

Room 10-146 Smilow Center

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Events

Epigenetics Institute Special Seminar

Thursday, May 2, 2019 fr0m 4-5PM

Room 12-146 Smilow Center

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Research

Drosophila ovary with whole-chromosome Oligopaints

Eric Joyce Lab Learn More

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Research

Budding enteroids (small intestinal organoids)

Arjun Lab and Andrea Stout Learn More

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Research

Metaphase chromosome spread stained with anti-Cenp-A.

Ben Black Lab Learn More

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Penn Epigenetics Institute

The goal of the Penn Epigenetics Institute is to advance basic and applied research in chromatin biology and epigenetics, building on current interest both in mechanisms underlying epigenetic regulation, and in unraveling genome-wide chromatin patterns, commonly known as epigenomes. While genetic approaches to altering cell and tissue function involve direct perturbation of the genome, epigenetic approaches involve the use of small molecules to modulate enzymes and chromatin binding proteins and thus provides a novel approach for developing therapies and diagnostics to improve human health. The Epigenetics Institute encourages collaborations between basic and clinical research in epigenetics. Common diseases, such as cancer and metabolic syndromes, as well as brain and memory function, are established and disrupted by these pathways. The Epigenetics Institute offers monthly research meetings, sponsors seminars, organizes annual symposia and retreats, recruits and mentors faculty, galvanizes large group projects leading to new research grant opportunities, establishes technology cores, among other long-term projects. The Epigenetics Institute currently encompasses a Core Group of 30 faculty members, and participation of more than 60 laboratories from the Philadelphia area, including Penn, CHOP, Wistar, Jefferson, Fox Chase, Drexel and Temple.

Featured Lab

Learn a little about the inner workings of our labs at the Penn Epigenetics Institute one month at a time, including photos and posts from lab members.

News

April 19, 2019

Anguera Lab Post #2 – Isabel Sierra, Graduate Student

Hey Isabel here, I’m a third year PhD student in the CAMB/DSRB graduate program. In…

April 17, 2019

VAHEDI LAB

Golnaz Vahedi contributed to a piece celebrating 25 years of the journal Immunity, providing her…

April 09, 2019

GREENBERG LAB

Roger Greenberg has been named the J. Samuel Staub, MD Endowed Professor at the Perelman…

April 09, 2019

GREENBERG LAB

Roger Greenberg will be a Keynote Speaker at the 2019 Midwest DNA Repair Symposium in…

April 05, 2019

Anguera Lab Post #1 – Camille Syrett, Graduate Student

Hi there, I’m Camille. As a sixth year CAMB/DSRB graduate student who recently defended, I’m…

March 26, 2019

Catching Up With PARS Alumni Briana Renn

Briana Renn wasn’t sure what career path she wanted to follow, then she took a…

March 25, 2019

WAGNER LAB

Congratulations to Doris Wagner for being named a 2019 Fellow of the American Society of…

March 25, 2019

CAPELSON LAB

Congratulations to Jennifer Aleman of the Capelson lab, 4th year CAMB-GE graduate student who was…

March 22, 2019

Garcia Lab Post #2 – Mariel Mendoza, Graduate Student

Hi, I’m Mariel. I’m a third year graduate student joint between Ben Garcia and Shelley…

March 14, 2019

LAZAR LAB

Dr. Mitch Lazar has been selected to receive the 2019 Rolf Luft Award from the Karolinska…

Publication Highlights

Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription. Behera V, Stonestrom AJ, Hamagami N, Hsiung CC, Keller CA, Giardine B, Sidoli S, Yuan Z-F, Bhanu NV, Werner MT, Wang H, Garcia BA, Hardison RC, Blobel GA. Cell Rep. 2019 Apr 9;27(2):400-415.e5. doi: 10.1016/j.celrep.2019.03.057. PMID: 30970245

Allele-specific RNA imaging shows that allelic imbalances can arise in tissues through transcriptional bursting.
Symmons O, Chang M, Mellis IA, Kalish JM, Park J, Suszták K, Bartolomei MS, Raj A.
PLoS Genet. 2019 Jan 9;15(1):e1007874. doi: 10.1371/journal.pgen.1007874. eCollection 2019 Jan.
PMID:30605160

Auxin Response Factors promote organogenesis by chromatin-mediated repression of the pluripotency gene SHOOTMERISTEMLESS. Chung Y, Zhu Y, Wu MF, Simonini S, Kuhn A, Armenta-Medina A, Jin R, Østergaard L, Gillmor CS, Wagner D. Nat Commun. 2019 Feb 21;10(1):886. doi: 10.1038/s41467-019-08861-3. PMID:30792395

Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence.
Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL. Mol Cell. 2019 Feb 8. pii: S1097-2765(19)30041-3. doi: 10.1016/j.molcel.2019.01.021. [Epub ahead of print]
PMID:30773298

Coordination between TGF-β cellular signaling and epigenetic regulation during epithelial to mesenchymal transition. Lu C, Sidoli S, Kulej K, Ross K, Wu CH, Garcia BA. Epigenetics Chromatin. 2019 Feb 8;12(1):11. doi: 10.1186/s13072-019-0256-y. PMID:30736855

Videos