Welcome to the Penn Epigenetics Institute


Intracytoplasmic Sperm Injection

Colin Conine Lab
Learn More



February 2020 Immunity Cover

Golnaz Vahedi Lab
Learn More


Seminar Series

Zuzana Tothova, MD, PhD and Jason Eccleston, MD

Check out our final monthly seminar series of the year! June 10th at 4 pm



Get to Know the Conine Lab

Conine Lab

The Conine lab studies RNA in sperm and its role in epigenetic inheritance. Get to know them here!



How the 3D organization of DNA controls cell identity

Jain Lab

The Jain lab is interested in stem cell biology, heart development, and genome organization. They have a passion for explaining science to the general public – check out their latest video!


Welcome from the Director

An epigenetic trait is defined as a stably heritable phenotype resulting from changes in a chromosome without alterations in the DNA sequence. At the Penn Epigenetics Institute, our group of talented faculty, trainees, and staff investigate all aspects of epigenetics – from its role in cancer, development, and immunity to how it affects social structures and the way our brains function. Our goal is to advance basic and applied research in chromatin biology and epigenetics, building on current interest both in mechanisms underlying epigenetic regulation and in unraveling genome-wide chromatin patterns.

The Institute was established in 2017 to bring together the epigenetics community at Penn, providing a space where scientific endeavors could flourish. With over 38 core labs, the Institute has created an unparalleled environment for collaboration and cutting-edge research, which is often published in top-tier journals. Faculty regularly collaborate with clinical investigators to conduct translational research that advances medical breakthroughs. Our reach goes beyond the Penn community, with participation from labs at CHOP, Wistar, Jefferson, Fox Chase, Drexel, and Temple. We engage with nationally and internationally renowned scientists at our monthly seminars and annual symposia. We continue to build the Institute by recruiting new faculty, engaging in large group projects that lead to new research grant opportunities, and establishing state-of-the-art technology cores.

To learn more about the Penn Epigenetics Institute, explore our website!

Congratulations to Gregory Schwartz!

Gregory Schwartz (postdoc in the Faryabi lab) will be starting his lab later this year as a faculty member at Princess Margaret Cancer Centre in Toronto. The lab will focus on developing new integrative methods and algorithms to better understand cellular heterogeneity in cancer. Congratulations Gregory!


June 22, 2021

Colin Conine selected as Pew Scholar in the Biomedical Sciences

Colin Conine has been selected as one of the 22 Pew Scholars in the Biomedical Sciences. Congratulations Colin!

June 22, 2021

Liling Wan selected as Pew-Stewart Scholar for Cancer Research

Liling Wan has been selected as one of the five Pew-Stewart Scholars for Cancer Research. Congratulations Liling!

June 22, 2021

Qinglan Li joins Wan lab

Qinglan Li has joined Liling Wan’s lab as a postdoc fellow. Welcome Qinglan!

June 22, 2021

Kaeli Mathias joins Wan lab

Kaeli Mathias (BMB graduate student) has joined Liling Wan’s lab. Welcome Kaeli!

June 22, 2021

Krista Budinich joins Wan lab

Krista Budinich (CAMB graduate student) has joined Liling Wan’s lab. Welcome Krista!

June 01, 2021

Jingru Zhao (Faryabi lab) passes qualifying exam

Congratulations to Jingru Zhao (CAMB graduate student) from the Faryabi Lab for passing her Ph.D. qualifying exam!

June 01, 2021

Marco Carpenter (Heller lab) successfully defends thesis; recipient of 2021 CHOP Postdoctoral Fellowship

Marco Carpenter (PGG graduate student in the Heller) successfully defended his dissertation and graduated. He is the first graduate student from the Heller Lab, a recipient of a 2021 CHOP…

May 24, 2021

Golnaz Vahedi promoted to Associate Professor

Golnaz Vahedi has been promoted with tenure to Associate Professor here at Penn. Congratulations Golnaz!

April 28, 2021

Marisa Bartolomei elected to the National Academy of Sciences

Marisa Bartolomei has been elected to the National Academy of Sciences. Congratulations Marisa!

April 28, 2021

Ken Zaret elected to the American Academy of Arts & Sciences

Ken Zaret was elected as a 2021 fellow of the American Academy of Arts & Sciences. Congratulations Ken!

Featured Labs

Conine Lab

The Conine lab studies RNA in sperm and its role in epigenetic inheritance. Get to know them here!

Anguera Lab

The Anguera lab studies X-inactivation and its role in immunity. Get to know them here!

Garcia Lab

The Garcia lab uses quantitative mass spectrometry-based proteomics to study epigenetics. Get to know them here!

Publication Highlights

From Shelley Berger Lab
From Eric Joyce Lab
From Arjun Raj Lab

Alexander KA, Coté A, Nguyen SC, Zhang L, Gholamalamdari O, Agudelo-Garcia P, Lin-Shiao E, Tanim KMA, Lim J, Biddle N, Dunagin MC, Good CR, Mendoza MR, Little SC, Belmont A, Joyce EF, Raj A, Berger SL. Mol Cell. 2021 Apr 15;81(8):1666-1681.e6. doi: 10.1016/j.molcel.2021.03.006. Epub 2021 Apr 5. PMID: 33823140

From Rajan Jain Lab

Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R. Cell Stem Cell. 2021 May 6;28(5):938-954.e9. doi: 10.1016/j.stem.2020.12.016. Epub 2021 Feb 1. PMID: 33529599

From Irfan Asangani Lab

Deng Q, Rasool RU, Russell RM, Natesan R, Asangani IA. iScience. 2021 Mar 19;24(3):102254. doi: 10.1016/j.isci.2021.102254. Epub 2021 Mar 1. PMID: 33681723

From Marisa Bartolomei Lab
From Roberto Bonasio Lab
From Rahul Kohli Lab

Caldwell BA, Liu MY, Prasasya RD, Wang T, DeNizio JE, Leu NA, Amoh NYA, Krapp C, Lan Y, Shields EJ, Bonasio R, Lengner CJ, Kohli RM, Bartolomei MS. Mol Cell. 2021 Feb 18;81(4):859-869.e8. doi: 10.1016/j.molcel.2020.11.045. Epub 2020 Dec 21. PMID: 33352108

From Gerd Blobel Lab
From Melike Lakadamyali Lab

Luan J, Xiang G, Gómez-García PA, Tome JM, Zhang Z, Vermunt MW, Zhang H, Huang A, Keller CA, Giardine BM, Zhang Y, Lan Y, Lis JT, Lakadamyali M, Hardison RC, Blobel GA. Cell Rep. 2021 Feb 23;34(8):108783. doi: 10.1016/j.celrep.2021.108783. PMID: 33626344


Contact the Institute

Epigenetics Institute
Department of Cell and Developmental Biology
9th Floor, Smilow Center for Translational Research
3400 Civic Center Blvd
Philadelphia, PA 19104
T: 215-573-5858


Sophia Castro-Anderson

Samantha Falk
Social Media Coordinator