Welcome to the Penn Epigenetics Institute

Research

Drosophilia ovary with whole chromosome oligopaints

Eric Joyce Lab

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Research

Budding enteroids (small intestinal organoids)

Arjun Lab & Andrea Stout

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Research

Initiation of chromosome folding following mitosis

Gerd Blobel Lab

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Penn Epigenetics Institute

The goal of the Penn Epigenetics Institute is to advance basic and applied research in chromatin biology and epigenetics, building on current interest both in mechanisms underlying epigenetic regulation, and in unraveling genome-wide chromatin patterns, commonly known as epigenomes. While genetic approaches to altering cell and tissue function involve direct perturbation of the genome, epigenetic approaches involve the use of small molecules to modulate enzymes and chromatin binding proteins and thus provides a novel approach for developing therapies and diagnostics to improve human health. The Epigenetics Institute encourages collaborations between basic and clinical research in epigenetics. Common diseases, such as cancer and metabolic syndromes, as well as brain and memory function, are established and disrupted by these pathways. The Epigenetics Institute offers monthly research meetings, sponsors seminars, organizes annual symposia and retreats, recruits and mentors faculty, galvanizes large group projects leading to new research grant opportunities, establishes technology cores, among other long-term projects. The Epigenetics Institute currently encompasses a Core Group of 30 faculty members, and participation of more than 60 laboratories from the Philadelphia area, including Penn, CHOP, Wistar, Jefferson, Fox Chase, Drexel and Temple.

Dr. Shelley Berger on FOX 29 Philly

Dr. Shelley Berger spoke to FOX 29 Philly about the latest paper from her lab, looking at how alcohol consumption affects the epigenetics of the brain. If you missed the clip, check it out here!

News

July 06, 2020

WAN LAB

Liling Wan is the recipient of a New Investigator Award from the Leukemia Research Foundation….

July 03, 2020

BERGER LAB

Congratulations to Balint Kacsoh, a postdoc in the Berger lab, on his admittance as an…

June 30, 2020

JOYCE LAB

Jenny Luppino, a graduate student (CAMB program) received an F31 award from NICHD for the…

June 29, 2020

WELLEN LAB

Julianna Supplee, a graduate student in the BMB program, has jointly joined the Wellen lab…

June 29, 2020

WELLEN LAB

Luke Izzo, a graduate student (CAMB program) in the Wellen lab, has been awarded a…

June 12, 2020

WAGNER LAB

Doris Wagner recently received an NSF Plant Genome Research Program Grant to examine whether there…

June 11, 2020

WU LAB

Alex Wei, a PhD student (NGG program) from the Wu lab recently received an F31…

June 09, 2020

HELLER LAB

Mike Murphy is a new PhD student (NGG program) in the Heller lab, and received…

June 09, 2020

HELLER LAB

Marco Carpenter, a graduate student in the Heller Lab, received the NIDA Drug Abuse Dissertation…

June 09, 2020

WELLEN LAB

Laura Pinheiro is a new PhD student (BMB program) in the Wellen lab. Welcome to…

Publication Highlights

Structural basis for allosteric PARP-1 retention on DNA breaks.

Zandarashvili L, Langelier MF, Velagapudi UK, Hancock MA, Steffen JD, Billur R, Hannan ZM, Wicks AJ, Krastev DB, Pettitt SJ, Lord CJ, Talele TT, Pascal JM, Black BE. Science. 2020;368(6486). pii: eaax6367. doi: 10.1126/science.aax6367. PMID:32241924

Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones.

Iwafuchi M, Cuesta I, Donahue G, Takenaka N, Osipovich AB, Magnuson MA, Roder H, Seeholzer SH, Santisteban P, Zaret KS. Nat Genet. 2020. doi: 10.1038/s41588-020-0591-8. [Epub ahead of print]. PMID:32203463

TooManyCells identifies and visualizes relationships of single-cell clades.

Schwartz GW, Zhou Y, Petrovic J, Fasolino M, Xu L, Shaffer SM, Pear WS, Vahedi G, Faryabi RB. Nat Methods. 2020. doi: 10.1038/s41592-020-0748-5. PMID:32123397

Joint profiling of chromatin accessibility and CAR-T integration site analysis at population and single-cell levels.

Wang W, Fasolino M, Cattau B, Goldman N, Kong W, Frederick MA, McCright SJ, Kiani K, Fraietta JA, Vahedi G. Proc. Natl. Acad. Sci. U.S.A. 2020;

Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression.

Fasolino M, Goldman N, Wang W, Cattau B, Zhou Y, Petrovic J, Link VM, Cote A, Chandra A, Silverman M, Joyce EF, Little SC; HPAP Consortium, Kaestner KH, Naji A, Raj A, Henao-Mejia J, Faryabi RB, Vahedi G. Immunity. 2020. pii: S1074-7613(20)30030-3. doi: 10.1016/j.immuni.2020.01.003. [Epub ahead of print]

Videos