Welcome to the Penn Epigenetics Institute

Research

Metaphase chromosome spread stained with anti-Cenp-A.

Ben Black Lab

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Research

Traces of telomere movement in response to DNA double-strand breaks

Roger Greenberg Lab

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Research

Drosophila chromosome territories revealed by Oligopaints

Eric Joyce Lab

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Penn Epigenetics Institute

The goal of the Penn Epigenetics Institute is to advance basic and applied research in chromatin biology and epigenetics, building on current interest both in mechanisms underlying epigenetic regulation, and in unraveling genome-wide chromatin patterns, commonly known as epigenomes.

While genetic approaches to altering cell and tissue function involve direct perturbation of the genome, epigenetic approaches involve the use of small molecules to modulate enzymes and chromatin binding proteins and thus provides a novel approach for developing therapies and diagnostics to improve human health.

The Epigenetics Institute encourages collaborations between basic and clinical research in epigenetics. Common diseases, such as cancer and metabolic syndromes, as well as brain and memory function, are established and disrupted by these pathways.

The Epigenetics Institute offers monthly research meetings, sponsors seminars, organizes annual symposia and retreats, recruits and mentors faculty, galvanizes large group projects leading to new research grant opportunities, establishes technology cores, among other long-term projects. The Epigenetics Institute currently encompasses a Core Group of 30 faculty members, and participation of more than 60 laboratories from the Philadelphia area, including Penn, CHOP, Wistar, Jefferson, Fox Chase, Drexel and Temple.

What is Epigenetics?

Watch one of the world’s most distinguished Epigeneticists, Dr. Shelley Berger, explain what Epigenetics is and how it is revolutionizing our understanding of genetic information.

News

July 16, 2018

BERGER LAB

Listen to Dr. Shelley Berger talk about the limitations of what our genes can determine.]…

July 12, 2018

GARCIA LAB

Geoff Dann, a postdoc from the Garcia lab, has been awarded a Damon Runyon Postdoctoral…

July 02, 2018

RAJ LAB

Using statistics to uncover the truth about individual cells Read More

June 26, 2018

PHILLIPS-CREMINS LAB

Jennifer Cremins has been awarded a Brain Research Foundation Seed Grant on ‘Elucidating the role…

June 19, 2018

GREENBERG LAB

Dr. Jie Chen received the Michael Brown Penn-GSK Postdoctoral Fellowship.

June 19, 2018

GARCIA LAB

Dr. Anumita Saha awarded a Michael S. Brown Penn-GSK Postdoctoral Fellowship

June 19, 2018

ANGUERA LAB

Montserrat Anguera was awarded an R01 from NIAID, “Gene regulation from the inactive X in…

May 29, 2018

ANGUERA LAB

Montserrat Anguera awarded a 2018 Department of Defense Lupus Research Program Grant.

May 29, 2018

BLACK LAB

Postdoctoral Fellow, Levani Zandarashvili, awarded an NIH Ruth L. Kirschstein National Research Service Award Individual…

May 29, 2018

BLACK LAB

Graduate student, Lucie Guo, won the Saul Winegrad Award for Outstanding Dissertation in Biochemistry &…

Publication Highlights

Lineage-determining transcription factor TCF-1 initiates the epigenetic identity of T cells. Johnson, J.L., Georgakilas, G., Petrovic, J., Kurachi, M., Cai, S., Harly, C., Pear, W.S., Bhandoola, A., Wherry, E., Vahedi G. Immunity. Cell Press, 48(2): 243-257, February 2018.

Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription. Kim YH, Marhon SA, Zhang Y, Steger DJ, Won KJ, Lazar MA. Science. 2018 Feb 8. pii: eaao6891. doi: 10.1126/science.aao6891.

Detecting hierarchical genome folding with network modularity. Norton HK, Emerson DJ, Huang H, Kim J, Titus KR, Gu S, Bassett DS, Phillips-Cremins JE. Nat Methods. 2018 Jan 15. doi: 10.1038/nmeth.4560.

Dissecting Cell-Type Composition and Activity-Dependent Transcriptional State in Mammalian Brains by Massively Parallel Single-Nucleus RNA-Seq. Hu P, Fabyanic E, Kwon DY, Tang S, Zhou Z, Wu H.  Mol Cell. 2017 Dec 7;68(5):1006-1015.e7. doi: 10.1016/j.molcel.2017.11.017.

Cytoplasmic chromatin triggers inflammation in senescence and cancer. Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL.  Nature. 2017 Oct 19;550(7676):402-406. doi: 10.1038/nature24050. Epub 2017 Oct 4.

Videos