Welcome to the Penn Epigenetics Institute

Epigenetics Institute Seminar Series

"Zinc Finger Protein evolution against transposons and its impact on mammals"

Dr. Todd Macfarlan
Thursday, December 13 @ 4 pm at 9-146 Smilow Center

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Research

Metaphase chromosome spread stained with anti-Cenp-A.

Ben Black Lab

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Research

Traces of telomere movement in response to DNA double-strand breaks

Roger Greenberg Lab

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Research

Drosophila chromosome territories revealed by Oligopaints

Eric Joyce Lab

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Penn Epigenetics Institute

The goal of the Penn Epigenetics Institute is to advance basic and applied research in chromatin biology and epigenetics, building on current interest both in mechanisms underlying epigenetic regulation, and in unraveling genome-wide chromatin patterns, commonly known as epigenomes.

While genetic approaches to altering cell and tissue function involve direct perturbation of the genome, epigenetic approaches involve the use of small molecules to modulate enzymes and chromatin binding proteins and thus provides a novel approach for developing therapies and diagnostics to improve human health.

The Epigenetics Institute encourages collaborations between basic and clinical research in epigenetics. Common diseases, such as cancer and metabolic syndromes, as well as brain and memory function, are established and disrupted by these pathways.

The Epigenetics Institute offers monthly research meetings, sponsors seminars, organizes annual symposia and retreats, recruits and mentors faculty, galvanizes large group projects leading to new research grant opportunities, establishes technology cores, among other long-term projects. The Epigenetics Institute currently encompasses a Core Group of 30 faculty members, and participation of more than 60 laboratories from the Philadelphia area, including Penn, CHOP, Wistar, Jefferson, Fox Chase, Drexel and Temple.

What is Epigenetics?

Watch one of the world’s most distinguished Epigeneticists, Dr. Shelley Berger, explain what Epigenetics is and how it is revolutionizing our understanding of genetic information.

News

November 26, 2018

CAPELL LAB

Received a $50,000 Developmental Research Award from the Penn-Wistar Skin Cancer SPORE, for work Defining and…

November 25, 2018

GREENBERG LAB

Mischa Li successfully defended her dissertation, entitled, TIP60-dependent histone acetylation promotes DNA repair by homologous recombination.

October 02, 2018

BERGER/GARCIA LABS

Mariel Mendoza (joint advised by Shelley Berger and Ben Garcia) has been awarded an NIH…

October 02, 2018

BARTOLOMEI LAB

Lisa Vrooman (postdoctoral fellow in the Bartolomei lab) was awarded best short talk at the…

October 02, 2018

BARTOLOMEI LAB

Aimee Juan (a combined degree student in the Bartolomei lab) was awarded an F31 from…

October 02, 2018

GREENBERG LAB

Roger Greenberg named co-Chair and Keynote Speaker, NCI Workshop on the BRCA phenotype and human…

September 17, 2018

PHILLIPS-CREMINS LAB

Disease-Associated Short Tandem Repeats Co-localize with Chromatin Domain Boundaries Read More.

September 14, 2018

GARCIA LAB

Simone Sidoli, a former postdoctoral fellow, has accepted a faculty position at the Albert Einstein…

September 12, 2018

GREENBERG LAB

Congratulations to Roger Greenberg on receiving this year’s Stanley N. Cohen Biomedical Research Award!

September 05, 2018

CREMINS LAB

MD/PhD candidate, Linda Zhou, of the Cremins lab is a recipient of the Blavatnik Family…

Publication Highlights

A changing paradigm of transcriptional memory propagation through mitosis. Katherine C. Palozola, Jonathan Lerner, Kenneth S. ZaretNature Reviews Molecular Cell Biology (2018) https://doi.org/10.1038/ s41580-018-0077-z

Targeted demethylation at the CDKN1C/p57 induces human β cell replication. Ou K, Yu M, Moss NG, Wang YJ, Wang AW, Nguyen SC, Jiang C, Feleke E, Kameswaran V, Joyce EF, Naji A, Glaser B, Avrahami D, Kaestner KHJ Clin Invest. 2018 Oct 23. pii: 99170. doi: 10.1172/JCI99170.

Systematic Evaluation of Soluble Protein Expression Using a Fluorescent Unnatural Amino Acid Reveals No Reliable Predictors of Tolerability.
Hostetler ZM, Ferrie JJ, Bornstein MR, Sungwienwong I, Petersson EJ, Kohli RM.
ACS Chem Biol. 2018 Oct 19;13(10):2855-2861. doi: 10.1021/acschembio.8b00696. Epub 2018 Sep 20.
PMID: 30216041

Phosphorylation of TIP60 suppresses 53BP1 localization at DNA damage sites.
Li ML, Jiang Q, Bhanu NV, Wu J, Li W, Garcia BA, Greenberg RA.
Mol Cell Biol. 2018 Oct 8. pii: MCB.00209-18. doi: 10.1128/MCB.00209-18. [Epub ahead of print]
PMID: 30297459

Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase.
Schutsky EK, DeNizio JE, Hu P, Liu MY, Nabel CS, Fabyanic EB, Hwang Y, Bushman FD, Wu H, Kohli RM.Nat Biotechnol. 2018 Oct 8. doi: 10.1038/nbt.4204. [Epub ahead of print]
PMID: 30295673

Videos