Welcome to the Penn Epigenetics Institute

Events

Epigenetics Seminar Series

“A disease-related chromatin loop in Alzheimer’s disease”
Thursday, November 16, 2017
4 PM – 5 PM
Law Auditorium, Jordan Medical Education Center

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Research

Nuclear structure in fly development

Maya Capelson’s Lab

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Publications

Penn Study Shows How Female Immune Cells Keep Their Second X Chromosome Shut Off

One of a female’s two X chromosomes gets inactivated in order to balance out gene expression between males and females. New research led by doctoral student Camille Syrett and professor Montserrat Anguera of the School of Veterinary Medicine nails down the mechanism governing this repression in the immune system’s B cells. Disruptions to the process may help explain the female bias in autoimmune disorders.

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Penn Epigenetics Institute

The goal of the UPenn Epigenetics Institute is to advance basic and applied research in chromatin biology and epigenetics, building on current interest both in mechanisms underlying epigenetic regulation, and in unraveling genome-wide chromatin patterns, commonly known as epigenomes.

While genetic approaches to altering cell and tissue function involve direct perturbation of the genome, epigenetic approaches involve the use of small molecules to modulate enzymes and chromatin binding proteins and thus provides a novel approach for developing therapies and diagnostics to improve human health.

The Epigenetics Institute encourages collaborations between basic and clinical research in epigenetics. Common diseases, such as cancer and metabolic syndromes, as well as brain and memory function, are established and disrupted by these pathways.

The Epigenetics Institute offers monthly research meetings, sponsors seminars, organizes annual symposia and retreats, recruits and mentors faculty, galvanizes large group projects leading to new research grant opportunities, establishes technology cores, among other long-term projects. The Epigenetics Institute currently encompasses a Core Group of 16 faculty members, and participation of more than 50 laboratories from the Philadelphia area, including Penn, CHOP, Wistar, Jefferson, Fox Chase, Drexel and Temple.

What is Epigenetics?

Watch one of the world’s most distinguished Epigeneticists, Dr. Shelley Berger, explain what Epignetics is and how it is revolutionizing our understanding of genetic information.

News

October 20, 2017

LEVINE LAB

Mia Levine awarded the NIGMS Maximizing Investigators’ Research Award (MIRA) (R35), “Causes and functional consequences…

October 20, 2017

RAJ LAB

Arjun Raj awarded a Chan-Zuckerberg Initiative Human Cell Atlas Grant, “Accelerating tools and technologies for…

October 18, 2017

ANGUERA LAB

Penn Study Shows How Female Immune Cells Keep Their Second X Chromosome Shut Off Learn…

October 12, 2017

EPSTEIN LAB

Research led by Rajan Jain and Jonathan Epstein of the Perelman School of Medicine suggests…

October 10, 2017

BERGER LAB

PIK professors Michael Platt and Shelley Berger are embarking on a joint research project focused…

October 09, 2017

WU LAB

Hao Wu of the Perelman School of Medicine has received the New Innovator Award from…

October 05, 2017

SARMA LAB

Kavitha Sarma, Ph.D. NIH awarded the Director’s New Innovator Award (DP2) for her research on…

October 04, 2017

BERGER LAB

Cell Stress Response Sheds Light on Treating Inflammation-related Cancer, Aging Learn More

October 02, 2017

ZHOU LAB

Barbara Terzic, graduate student from the Zhou lab, awarded an NIH F31 NRSA, “Investigating the…

September 30, 2017

SONG LAB

How Brain Develops Before Birth is Tightly Controlled by RNA Modification Learn More  

Publication Highlights

Gospocic J, Shields EJ, Glastad KM, Lin Y, Penick CA, Yan H, Mikheyev AS, Linksvayer TA, Garcia BA, Berger SL, Liebig J, Reinberg D, Bonasio R.

Cell. 2017 Aug 10;170(4):748-759.e12. doi: 10.1016/j.cell.2017.07.014

Emmett MJ, Lim HW, Jager J, Richter HJ, Adlanmerini M, Peed LC, Briggs ER, Steger DJ, Ma T, Sims CA, Baur JA, Pei L, Won KJ, Seale P, Gerhart-Hines Z, Lazar MA.

Nature. 2017 Jun 22;546(7659):544-548. doi: 10.1038/nature22819. Epub 2017 Jun 14.

 

Videos