Welcome to the Penn Epigenetics Institute

Research

Metaphase chromosome spread stained with anti-Cenp-A.

Ben Black’s Lab

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Research

Traces of telomere movement in response to DNA double-strand breaks

Roger Greenberg’s Lab

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Publications

Penn biologists show how plants turn off genes they don't need

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Distinguished Seminar Series

Genome regulation during developmental transitions: Generating robustness and precision

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Epigenetics Institute Seminar Series

Developmental Epigenetics Interest Group Talks

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Penn Epigenetics Institute

The goal of the Penn Epigenetics Institute is to advance basic and applied research in chromatin biology and epigenetics, building on current interest both in mechanisms underlying epigenetic regulation, and in unraveling genome-wide chromatin patterns, commonly known as epigenomes.

While genetic approaches to altering cell and tissue function involve direct perturbation of the genome, epigenetic approaches involve the use of small molecules to modulate enzymes and chromatin binding proteins and thus provides a novel approach for developing therapies and diagnostics to improve human health.

The Epigenetics Institute encourages collaborations between basic and clinical research in epigenetics. Common diseases, such as cancer and metabolic syndromes, as well as brain and memory function, are established and disrupted by these pathways.

The Epigenetics Institute offers monthly research meetings, sponsors seminars, organizes annual symposia and retreats, recruits and mentors faculty, galvanizes large group projects leading to new research grant opportunities, establishes technology cores, among other long-term projects. The Epigenetics Institute currently encompasses a Core Group of 30 faculty members, and participation of more than 60 laboratories from the Philadelphia area, including Penn, CHOP, Wistar, Jefferson, Fox Chase, Drexel and Temple.

What is Epigenetics?

Watch one of the world’s most distinguished Epigeneticists, Dr. Shelley Berger, explain what Epigenetics is and how it is revolutionizing our understanding of genetic information.

News

May 14, 2018

GARCIA LAB

Ben Garcia has been awarded the Biemann Medal by the American Society for Mass Spectrometry…

May 01, 2018

BERGER LAB

Congratulations to our Epigenetics Institute Leader, Shelley Berger, for being elected to the National Academy…

April 21, 2018

CAPELL LAB

Congratulations to Brian Capell for being awarded the Young Physician Scientist Award from the American…

April 10, 2018

GREENBERG LAB

Graduate student Qinqin Jiang will defend her PhD on April 6th and begin a postdoc…

April 10, 2018

GREENBERG LAB

Postdoc Shane Harding has accepted a faculty position as Assistant Professor, Princess Margaret Hospital, University…

March 26, 2018

BLACK LAB

Ben Black promoted to full professor.

March 26, 2018

WAGNER LAB

Doris Wager appointed as the Robert I. Williams Term Professor of Biology,  a five year…

March 15, 2018

CAPELL LAB

Brian Capell has been awarded the Basic/Translational Research Award.   Read More. 

March 15, 2018

BERGER LAB

Penn Study Shows that the “Epigenetic Landscape” is Protective in Normal Aging, Impaired in Alzheimer’s…

March 07, 2018

BERGER LAB

Penn Study Shows that the “Epigenetic Landscape” is Protective in Normal Aging, Impaired in Alzheimer’s…

Publication Highlights

Lineage-determining transcription factor TCF-1 initiates the epigenetic identity of T cells. Johnson, J.L., Georgakilas, G., Petrovic, J., Kurachi, M., Cai, S., Harly, C., Pear, W.S., Bhandoola, A., Wherry, E., Vahedi G. Immunity. Cell Press, 48(2): 243-257, February 2018.

Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription. Kim YH, Marhon SA, Zhang Y, Steger DJ, Won KJ, Lazar MA. Science. 2018 Feb 8. pii: eaao6891. doi: 10.1126/science.aao6891.

Detecting hierarchical genome folding with network modularity. Norton HK, Emerson DJ, Huang H, Kim J, Titus KR, Gu S, Bassett DS, Phillips-Cremins JE. Nat Methods. 2018 Jan 15. doi: 10.1038/nmeth.4560.

Dissecting Cell-Type Composition and Activity-Dependent Transcriptional State in Mammalian Brains by Massively Parallel Single-Nucleus RNA-Seq. Hu P, Fabyanic E, Kwon DY, Tang S, Zhou Z, Wu H.  Mol Cell. 2017 Dec 7;68(5):1006-1015.e7. doi: 10.1016/j.molcel.2017.11.017.

Cytoplasmic chromatin triggers inflammation in senescence and cancer. Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, Shoshkes-Carmel M, Tanim KMAA, Barber GN, Seykora JT, Millar SE, Kaestner KH, Garcia BA, Adams PD, Berger SL.  Nature. 2017 Oct 19;550(7676):402-406. doi: 10.1038/nature24050. Epub 2017 Oct 4.

Videos