Welcome to the Penn Epigenetics Institute

Research

Call for 2019 Epigenetics Institute Pilot Grant Applications

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2018-2019 Epigenetics Institute Seminar Series

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Research

Metaphase chromosome spread stained with anti-Cenp-A.

Ben Black Lab

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Research

Traces of telomere movement in response to DNA double-strand breaks

Roger Greenberg Lab

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Research

Drosophila chromosome territories revealed by Oligopaints

Eric Joyce Lab

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Penn Epigenetics Institute

The goal of the Penn Epigenetics Institute is to advance basic and applied research in chromatin biology and epigenetics, building on current interest both in mechanisms underlying epigenetic regulation, and in unraveling genome-wide chromatin patterns, commonly known as epigenomes.

While genetic approaches to altering cell and tissue function involve direct perturbation of the genome, epigenetic approaches involve the use of small molecules to modulate enzymes and chromatin binding proteins and thus provides a novel approach for developing therapies and diagnostics to improve human health.

The Epigenetics Institute encourages collaborations between basic and clinical research in epigenetics. Common diseases, such as cancer and metabolic syndromes, as well as brain and memory function, are established and disrupted by these pathways.

The Epigenetics Institute offers monthly research meetings, sponsors seminars, organizes annual symposia and retreats, recruits and mentors faculty, galvanizes large group projects leading to new research grant opportunities, establishes technology cores, among other long-term projects. The Epigenetics Institute currently encompasses a Core Group of 30 faculty members, and participation of more than 60 laboratories from the Philadelphia area, including Penn, CHOP, Wistar, Jefferson, Fox Chase, Drexel and Temple.

What is Epigenetics?

Watch one of the world’s most distinguished Epigeneticists, Dr. Shelley Berger, explain what Epigenetics is and how it is revolutionizing our understanding of genetic information.

News

September 17, 2018

PHILLIPS-CREMINS LAB

Disease-Associated Short Tandem Repeats Co-localize with Chromatin Domain Boundaries Read More.

September 14, 2018

GARCIA LAB

Simone Sidoli, a former postdoctoral fellow, has accepted a faculty position at the Albert Einstein…

September 12, 2018

GREENBERG LAB

Congratulations to Roger Greenberg on receiving this year’s Stanley N. Cohen Biomedical Research Award!

September 05, 2018

CREMINS LAB

MD/PhD candidate, Linda Zhou, of the Cremins lab is a recipient of the Blavatnik Family…

August 08, 2018

2018 Kaushal Family Awards in Genetics

The Department of Genetics is pleased to announce the winners of the 2018 Kaushal Family…

August 08, 2018

2018 Kadesch Prize in Genetics

In 2011, the Department of Genetics established the “Tom Kadesch Prize in Genetics” to honor…

August 08, 2018

GARCIA LAB

Former resident fellow in the lab, Dr. John Wojcik, began his appointment as an Assistant…

July 31, 2018

BARTOLOMEI LAB

How Dad’s Genes Can Prepare Mom for Parenthood Read More

July 31, 2018

GREENBERG LAB

Robert L. Dilley successfully defended his thesis entitled, Mechanisms of Telomere Repair Synthesis.

July 26, 2018

BONASIO LAB

Worker Ants: You Could Have Been Queens Read More

Publication Highlights

Long genes linked to autism spectrum disorders harbor broad enhancer-like chromatin domains. Zhao YT, Kwon DY, Johnson BS, Fasolino M, Lamonica JM, Kim YJ, Zhao BS, He C, Vahedi G, Kim TH, Zhou ZGenome Res. 2018 Jul;28(7):933-942. doi: 10.1101/gr.233775.117. Epub 2018 May 30.

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells. Grevet JD, Lan X, Hamagami N, Edwards CR, Sankaranarayanan L, Ji X, Bhardwaj SK, Face CJ, Posocco DF, Abdulmalik O, Keller CA, Giardine B, Sidoli S, Garcia BA, Chou ST, Liebhaber SA, Hardison RC, Shi J, Blobel GAScience. 2018 Jul 20;361(6399):285-290. doi: 10.1126/science.aao0932

EpiProfile 2.0: A Computational Platform for Processing Epi-Proteomics Mass Spectrometry Data. Yuan ZF, Sidoli S, Marchione DM, Simithy J, Janssen KA, Szurgot MR, Garcia BAJ Proteome Res. 2018 Jul 6;17(7):2533-2541. doi: 10.1021/acs.jproteome.8b00133. Epub 2018 May 30.

Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK. Gottlieb L, Marmorstein R. Structure. 2018 Jul 3;26(7):925-935.e8. doi: 10.1016/j.str.2018.04.003.

Recurrent amplification of the Heterochromatin Protein 1 (HP1) gene family across Dipter. Helleu Q, Levine MT. Mol Biol Evol. 2018 Jun 19. doi: 10.1093/molbev/msy128. [Epub ahead of print]

Videos