Welcome to the Penn Epigenetics Institute

Research

Drosophilia ovary with whole chromosome oligopaints

Eric Joyce Lab

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Research

Budding enteroids (small intestinal organoids)

Arjun Lab & Andrea Stout

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Research

Initiation of chromosome folding following mitosis

Gerd Blobel Lab

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Penn Epigenetics Institute

The goal of the Penn Epigenetics Institute is to advance basic and applied research in chromatin biology and epigenetics, building on current interest both in mechanisms underlying epigenetic regulation, and in unraveling genome-wide chromatin patterns, commonly known as epigenomes. While genetic approaches to altering cell and tissue function involve direct perturbation of the genome, epigenetic approaches involve the use of small molecules to modulate enzymes and chromatin binding proteins and thus provides a novel approach for developing therapies and diagnostics to improve human health. The Epigenetics Institute encourages collaborations between basic and clinical research in epigenetics. Common diseases, such as cancer and metabolic syndromes, as well as brain and memory function, are established and disrupted by these pathways. The Epigenetics Institute offers monthly research meetings, sponsors seminars, organizes annual symposia and retreats, recruits and mentors faculty, galvanizes large group projects leading to new research grant opportunities, establishes technology cores, among other long-term projects. The Epigenetics Institute currently encompasses a Core Group of 30 faculty members, and participation of more than 60 laboratories from the Philadelphia area, including Penn, CHOP, Wistar, Jefferson, Fox Chase, Drexel and Temple.

Dr. Shelley Berger on FOX 29 Philly

Dr. Shelley Berger spoke to FOX 29 Philly about the latest paper from her lab, looking at how alcohol consumption affects the epigenetics of the brain. If you missed the clip, check it out here!

News

September 02, 2020

GARCIA LAB

Ben Garcia has been named a Fellow of the Royal Society of Chemistry. Congratulations!

September 02, 2020

GARCIA LAB

Ben Garcia has been selected to receive the HUPO Discovery in Proteomics Science Award. Congratulations!

September 02, 2020

GARCIA LAB

Neha Srikumar was awarded a graduate fellowship slot on the NIH T32 Structural Biology and…

September 02, 2020

GARCIA LAB

Heejong Kim was awarded an NIH NRSA F31 Graduate Fellowship from the NIA. Congratulations!

September 02, 2020

GARCIA LAB

Lindsay Pino was awarded a postdoctoral fellowship slot on the Immunology of Normal and Neoplastic…

September 02, 2020

LEVINE LAB

Mia Levine and Mike Lampson have received an R21 award from NIH/NICHD, titled “Evolutionary innovation…

September 02, 2020

HELLER LAB

Michael D. Murphy, a graduate student in the Heller Lab, was awarded an NSF Graduate…

September 02, 2020

BARTOLOMEI LAB

Rexxi Prasasya in the Bartolomei lab was awarded an NIH NRSA postdoctoral fellowship. Congratulations!

September 02, 2020

VAHEDI LAB

Golnaz Vahedi is the recipient of a Burroughs Wellcome Fund for 2020 Investigators in the…

September 02, 2020

KORB LAB

Erica Korb is the recipient of a NARSAD Young Investigator Award from the Brain and…

Publication Highlights

Massively parallel and time-resolved RNA sequencing in single cells with scNT-seq

Qiu Q, Hu P, Qiu X, Govek KW, Cámara PG, Wu H. Nat Methods. 2020 Aug 31. doi: 10.1038/s41592-020-0935-4. PMID: 32868927

Alteration of genome folding via contact domain boundary insertion

Zhang D, Huang P, Sharma M, Keller CA, Giardine B, Zhang H, Gilgenast TG, Phillips-Cremins JE, Hardison RC, Blobel GA. Nat Genet. 2020 Aug 31. doi: 10.1038/s41588-020-0680-8. PMID: 32868908

Disruption of ATRX-RNA interactions uncovers roles in ATRX localization and PRC2 function

Ren W, Medeiros N, Warneford-Thomson R, Wulfridge P, Yan Q, Bian J, Sidoli S, Garcia BA, Skordalakes E, Joyce E, Bonasio R, Sarma K. Nat Commun. 2020;11(1):2219. doi: 10.1038/s41467-020-15902-9. PMID: 32376827

Structural basis for allosteric PARP-1 retention on DNA breaks.

Zandarashvili L, Langelier MF, Velagapudi UK, Hancock MA, Steffen JD, Billur R, Hannan ZM, Wicks AJ, Krastev DB, Pettitt SJ, Lord CJ, Talele TT, Pascal JM, Black BE. Science. 2020;368(6486). pii: eaax6367. doi: 10.1126/science.aax6367. PMID:32241924

Gene network transitions in embryos depend upon interactions between a pioneer transcription factor and core histones.

Iwafuchi M, Cuesta I, Donahue G, Takenaka N, Osipovich AB, Magnuson MA, Roder H, Seeholzer SH, Santisteban P, Zaret KS. Nat Genet. 2020. doi: 10.1038/s41588-020-0591-8. [Epub ahead of print]. PMID:32203463

Videos