Courses of Interest

Doris Wagner

BIOL4234/CAMB4830: Epigenetics (Spring)

This course investigates epigenetic phenomena: heritable alternate states of gene activity that do not result from an alteration in nucleotide composition (mutations). Epigenetic mechanisms regulate genome accessibility and cell differentiation. They play a key role in normal development and disease, as well as stress response. Amongst the epigenetic mechanisms we will discuss in this course are chromatin assembly, chromatin remodeling, histone modifications and histone variants, epigenome engineering, polycomb, DNA methylation and non-coding RNAs, nuclear architecture. The course is geared toward advanced undergraduate and graduate students and is a combination of short background lectures, analysis of the recent scientific literature and research presentations by guest speakers.

Roberto Bonasio & Thomas Jongens

BIOM5550: Regulation of the Genome (Spring)

Regulation of gene expression including chromatin structure, transcription, DNA modification, RNA processing, translation, control of gene expression via microRNAs and post-translational processing.

Irfan Asangani &  Luca Busino


This seminar course focuses on molecular and biochemical events that regulate cell cycle progression and genome maintenance, and explores how these processes influence cancer etiology and treatment. Specific topics will familiarize students with the key principles and recent developments within these areas. These topics include CDK-Cyclins and their inhibitors, regulation of G1-S and G2-M phase cell cycle transitions, DNA damage checkpoints and repair, the impact of chromatin regulation on DNA repair, and how each of these processes affects cancer etiology and treatment. In depth reading and evaluation of research literature will be primarily used to accomplish these aims, as well as provide instruction on rigorous experimental design and data interpretation.

Zhaolan (Joe) Zhou, Erica Korb, & Hao Wu

CAMB7130 Neuroepigenetics / NGG 7130 Neuroepigenetics (Fall)

This is a course intended to bring students up to date concerning our understanding of Neural Epigenetics. It is based on assigned topics and readings covering a variety of experimental systems and concepts in the field of Neuroepigenetics, formal presentations by individual students, critical evaluation of primary data, and in-depth discussion of potential issues and future directions, with goals to: 1) Review basic concepts of epigenetics in the context of neuroscience, 2) Learn to critically evaluate a topic (not a single paper) and set the premise, 3) Improve experimental design and enhance rigor and reproducibility, 4) Catch up with the most recent development in neuroepigenetics, 5) Develop professional presentation skills – be a story teller.

Bomyi Lim

CBE5170: Principles of Genome Engineering

This course covers up-to-date techniques in genome engineering and its application in basic research and translational medicine. Genetic engineering techniques including site-directed DNA recombination (Cre-Lox, Phi31 integrase), genome editing (TALEN, CRISPR/Cas-9), next generation sequencing, and molecular imaging will be covered. Key concepts in genomics, epigenetics, gene regulation will be introduced, and application of genetic engineering techniques in the field of developmental biology, stem cell biology, and synthetic biology will be discussed.
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