At-Large Pilot Project Grant
The Penn Epigenetics Program Institute announces a request for applications of a Pilot Project Grant for faculty to conduct epigenetics-related research projects. A broad spectrum of proposal topics will be considered, including those that involve fundamental studies in epigenetics as well as more applied or disease oriented studies that utilize epigenetics as a central component of the research.
Award Dates:
- Applications closed until next May 2023.
Epigenetics Spatial Transcriptomics Pilot Grant
The Epigenetics Institute seeks proposals for pilot grants for the evaluation of technologies for spatial transcriptomics. The goal of the program is to catalyze the use of spatial transcriptomics in the Epigenetics community and to help the Epigenetics Institute evaluate technologies with the aim of potentially committing to a commercial solution. The pilot grant itself will fund the generation of a spatial transcriptomics dataset from a company by a fee-for-service model. Analysis will be done by the PI’s team with possible help from the Epigenetics Institute. We ask that all awardees make their data available to the Epigenetics Institute, which will then be used as part of a report and internal data repository for others within the Epigenetics Institute to help them evaluate these methods for use in their own work.
Award Dates:
- No application deadline, so first come, first serve to some extent. Applications are short, just a page, really. Drs. Jennifer Phillips-Cremins and Arjun Raj will conduct the review with consultation by Dr. Shelley Berger. We strongly encourage interested faculty to reach out to Drs. Raj and Cremins informally to discuss options.
Questions?
Email Sophia Castro-Anderson at andes@pennmedicine.upenn.edu.
Past Pilot Grant Awardees Section
| Year(s) Awarded | Investigator(s) | Title of Project | Publication(s) | Grant Submission(s) |
|---|---|---|---|---|
| 2023 | George Burslem, Ph.D. & Andrey Poleshko, Ph.D. | Unbiased Probe Discover for Epigenetics Reprogramming | N/A | N/A |
| 2023 | Wanding Zhou, Ph.D., 8 Rahul Kohli, M.D., Ph.D. & Marisa Bartolomei, Ph.D. | Comprehensive resolution of epigenome diversity using the ternary-code DNA modification | N/A | N/A |
| 2023 | Erica Korb, Ph.D. & George Burslem, Ph.D. | Developing tools to examine the role and regulation of histone crotonylation in the brain | N/A | N/A |
| 2020 | Brian Capell, M.D., Ph.D & Kathy Fange Liu, Ph.D. | Defining the m6A epitranscriptome in epithelial gene regulaLon, development, and carcinogenesis | N/A | N/A |
| 2020 | Roberto Bonasio, Ph.D. & Elizabeth Heller, Ph.D. | In search of the epigeneQc engram in planarians | N/A | N/A |
| 2019 & 2020 | Elizabeth Heller, Ph.D. & Zhaolan Zhou, Ph.D. | Application of a novel method for neuronal cell-type specific simultaneous transcriptome and epigenome profiling in vivo in mice | N/A | N/A |
| 2019 & 2020 | Junwei Shi, Ph.D. | Develop a Cas 12a-based genetic method to identify paired epigenetic dependencies in acute myeloid leukemia | N/A | N/A |
| 2018 & 2019 | Eric Joyce, Ph.D., Melike Lakadamyali, Ph.D. & Rajan Jain, M.D. | Inheritance of Lamin-associated domains and their role in maintaining cellular identity | N/A | N/A |
| 2018 & 2019 | Maya Capelson, Ph.D. & Eric Joyce, Ph.D. | Identifying regulators of nuclear gene positioning via a high-throughput imaging screen. | Alejandro Gozalo, Ashley Duke, Yemin Lan, Pau Pascual-Garcia, Jessica A. Talamas, Son Nguyen, Eric F. Joyce and Maya Capelson. Core components of the nuclear pore bind distinct states of chromatin and contribute to Polycomb repression. In review at Mol Cell | N/A |
| 2017 & 2018 | Hao Wu, Ph.D. & Rahul M. Kohli, M.D., Ph.D. | APOBEC-Coupled Epigenetic Sequencing | EK Schutsky, JE DeNizio, P Hu, MY Liu, CS Nabel, EB Fabyanic, Y Hwang, FD Bushman, H Wu, RM Kohli, Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase. Nature Biotechnology, accepted on 24 May 2018. | N/A |
| 2017 & 2018 | Golnaz Vahedi, Ph.D. & Nancy A. Speck, Ph.D | Uncovering regulatory coordination during T cell development using single-cell epigenomics | N/A | Submitted to NIDDK in May 2018 |
| 2015 & 2017 | Benjamin Garcia, Ph.D. | A novel mass spectrometry based platform for characterization of microRNA (miRNA) post-transcriptional modifications | N/A | N/A |
| 2015 & 2017 | Robert Babak Faryabi, Ph.D. & Warren S. Pear, M.D., Ph.D. | Interrogating the oncogenic enhancer landscape in B cell lymphoma | Notch-Regulated Enhancers in B-Cell Lymphoma Activate MYC and Potentiate B-Cell Receptor Signaling. Russell JH Ryan, Jelena Petrovic, Dylan Rausch, Caleb Lareau, Winston Lee, Laura Donohue, Amanda L Christie, Shawn Gillespie, Michael J Kluk, Valentina Nardi, Robert B Faryabi, Ephraim P Hochberg, David M Weinstock, Bradley E Bernstein, Jon C Aster, Warren S Pear. Blood Dec 2016. | 1) Targeting the Notch:Myc axis in leukemia/lymphoma, NCI R01. Scored at 12th percentile (Nov 2016), current NCI payline is 10th percentile. 2) Oncogenic Notch Signaling P01 (submitted September 2016) |
| 2015 | Arjun Raj, Ph.D. & Roberto Bonasio, Ph.D. | CRISPR Drop-seq | N/A | N/A |
| 2013 & 2014 | Ben Black, Ph.D. & Michael Lampson, Ph.D. | Maintaining centromere identity in mammalian oocytes | N/A | N/A |
| 2013 & 2014 | Hua-Ying Fan, Ph.D. | Mechanisms of Transcription Memory Maintenance by the Notch Pathway Effector RBPJ | RBPJ, the major transcriptional effector of Notch signaling, remains associated with chromatin throughout mitosis, suggesting a role in mitotic bookmarking. Lake RJ, Tsai PF, Choi I, Won KJ, Fan HY. PLoS Genet. 2014 Mar 6;10(3):e1004204. doi: 10.1371/journal.pgen.1004204. eCollection 2014 Mar. Erratum in: PLoS Genet. 2016 Jul;12(7):e1006209. PMID:24603501 | NIH/NIGMS 1R01GM114132-01 Title: Mechanistic basis for mitotic transcriptional memory |
| 2013 & 2014 | Maya Capelson, Ph.D. & Sara Cherry, Ph.D. | Defining Role of Nuclear Pore Proteins in Antiviral Gene Expression | Nup98 promotes antiviral gene expression to restrict RNA viral infection in Drosophila. Panda D, Pascual-Garcia P, Dunagin M, Tudor M, Hopkins KC, Xu J, Gold B, Raj A, Capelson M, Cherry S.Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):E3890-9. doi: 10.1073/pnas.1410087111. Epub 2014 Sep 2. PMID:25197089 | N/A |
| Year(s) Awarded | Investigator(s) | Title of Project | Publication(s) |
|---|---|---|---|
| 2020 | Erica Korb, Ph.D. | Unique Properties of Histone Variant Proteins in the Brain | N/A |
| 2019 | Roger Greenberg, M.D., Ph.D. & Luca Busino, Ph.D. | Determine protein degradation at the Chromatin Double Strand Breaks | N/A |
| 2018 | Kathryn Wellen, Ph.D. | Diet and epigenetic regulation of liver metabolism | N/A |
| 2017 | Sarah E. Millar, Ph.D. | Identification of non-histone targets of Class I histone deacetylases in embryonic and adult epidermis and basal cell carcinoma | Zhu X, Leboeuf M, Liu F, Chen S, Olson EN, Morrisey EE, Dlugosz AA, Millar, SE. (2018). HDAC1 and HDAC2 regulate homeostasis and tumorigenesis of postnatal epidermis. Journal of Investigative Dermatology 138, S28 |
| Year Awarded | Investigator/s | Title of Project | Publications | Grant Submissions |
|---|---|---|---|---|
| 2017 | Irfan A. Asangani, Ph.D. | High throughput screening of FDA approved drugs with EZH2 inhibitor in prostate cancer cells |
| Year Awarded | Investigator(s) | Title of Project | Publication(s) | Grant Submission(s) |
|---|---|---|---|---|
| 2023 | Doris Wagner | Stem cell termination during reproductive development in plants | N/A | N/A |
| 2023 | Sydney Shaffer | Spatiallt-resolved evolution of dysplasia in the esophagus | N/A | N/A |