Positions
Faryabi Lab (https://faryabilab.com/) at the University of Pennsylvania School of Medicine invites highly motivated postdoctoral applicants to lead one of our 3D cancer genomic projects supported by four NIH grants. The primary focus of the lab is to elucidate mechanisms of chromatin reorganization in cancer and exploit them as new therapeutics (Zhou et al. Molecular Cell 2022, Petrovic et al. Molecular Cell 2019, Schwartz et al. Nature Methods 2020, Schwartz et al. Cell Reports 2021). Our enthusiastic and goal-oriented team of experimental and computational researchers works on the intersection of chromatin and cancer biology, and blends in state-of-the-arts functional and chromatin conformation genomics, super-resolution imaging and advanced computational analysis to understand how chromatin state and folding are aberrantly regulated in T cell leukemia, B cell lymphoma, and breast cancer. Further information about the lab could be found at https://faryabilab.com/.
These positions are for post-PhD trainees who are preparing for a research scientist career path. As a core member of the Penn Epigenetics Institute, Abramson Cancer Center, and Penn Center for Personalized Medicine, our lab provides a rich multi-disciplinary training environment that enables career independence through development of professional skills, scholarly publications, and grant applications. This research will help a postdoctoral scholar develop a unique niche in cancer research at the cross-section of cancer chromatin organization, epigenetics, and single-cell research. The postdoctoral researchers will test the role of genome topology regulators in vitro and mouse xenografts, generate and analyze various epigenomic data types, and conduct super-resolution microscopy studies.
Essential Qualifications:
- PhD in biological sciences with at least one first-author publication.
- Proficiency in standard biochemical, genome editing, and fluorescence microscopy techniques.
Preferred Qualifications:
- Experience in chromatin profiling, conformation capture, and high-resolution microscopy techniques.
- Experience in epigenomics and/or high-content imaging data analysis.
Application Processes:
Interested applicants should submit their CV, cover letter, and contact information of three references to faryabi@pennmedicine.upenn.edu.
Postdoc opportunity studying genetic conflict, chromosome biology, and the early embryo
The Levine Lab at the University of Pennsylvania (https://web.sas.upenn.edu/levine-lab/) is recruiting postdoctoral research scientists. Our lab integrates evolutionary genetics and cell biology to investigate genetic conflict between host genomes and their selfish genetic elements. We study how these ‘molecular arms races’ shape chromosome stability and genome evolution. Drosophila is our primary model.
The Levine Lab is housed in UPenn’s Department of Biology (www.bio.upenn.edu), a diverse, interactive community with breadth and depth in evolutionary genetics and genomics, cell biology, and molecular genetics. The Levine Lab is also a core member of the Epigenetics Institute at the Perelman School of Medicine (https://hosting.med.upenn.edu/epigenetics/), a group of 30+ lab groups dedicated to mechanistic dissection of epigenetic regulation and inheritance in healthy and disease states. The Levine Lab is also a core member of the Penn Center for Genome Integrity at the Perelman School of Medicine (https://www.med.upenn.edu/pcgi/).
The Levine Lab aims to recruit applicants with a PhD in either evolutionary genetics/genomics (but motivated to learn molecular and cell biology) OR in chromosome biology (but motivated to learn evolutionary genomics). Please send a cover letter that includes a description of how you envision integrating into our research goals, a CV, and a list of three references as a single PDF to m.levine [at] sas.upenn.edu, subject: “Postdoc opportunity.” Applications will be reviewed starting April 15th.
https://goo.gl/xW7nmfCandidates are required to hold a PhD in computer science, engineering, bioinformatics or related areas. Expertise in machine learning and statistics in addition to programing in Python and R in a Unix environment is required. Experience in genomics and epigenomics will be viewed favorably. Preference will be given to candidates with demonstrated experience in analyzing genome-wide chromatin conformation or single-cell genomics data sets.Further information about our lab could be found at http://vahedilab.github.io/LabSite/Interested applicants should submit a CV to vahedilab.jobs@gmail.com…
A Post-Doctoral Fellow position in Cancer Epigenomics and Transcriptional Addiction is available immediately in the Asangani lab at Dept. of Cancer Biology, Perelman School of Medicine, University of Pennsylvania.
https://www.med.upenn.edu/apps/faculty/index.php/g275/p8862482
The laboratory seeks to understand the role of epigenetic regulators in cancer pathophysiology by utilizing a multidisciplinary approach from high-throughput sequencing-based techniques, molecular biology, biochemistry, in vivo mouse models of cancer, and pharmacological interventions. For further information on the research see Nature (2014 PMID # 24759320), Molecular Cell (2013 PMID # 23159737), Cell Reports (2018 PMID # 29490263), Cancer Research (2018 PMID # 29898995) Cancer Discovery (2019 PMID # 31466944), Cancer Discovery (2020 PMID # 32188706), iScience (2021 PMID # 33681723).
Candidates should have obtained a Ph.D. degree in biomedical sciences, preferentially cancer biology. We are looking for individuals who are self-motivated, highly independent, and creative team players. Applicants with a strong experimental background in biochemistry, molecular and cellular biology and/or epigenetics are encouraged to apply. Previous experience in bioinformatics is appreciated but not strictly required.
Please submit a curriculum vitae, cover letter and contact details of two references to asangani@upenn.edu
A postdoctoral position is available in the lab of Dr. Ben Black (http://hosting.med.upenn.edu/blacklab/) within the Department of Biochemistry & Biophysics and the Epigenetics Program of the Perelman School of Medicine at the University of Pennsylvania. The lab consists of a team of cross-disciplinary and interactive scientists answering pressing questions in chromosome biology. The work has implications for cancer, human reproduction, synthetic biology, speciation mechanisms in mammals, and understanding fundamental epigenetic processes at the molecular level. We are very active in scientific interactions across several departments, programs, and schools here at UPenn. We are also co-founders of the multi-lab group meetings of the Philly Chromosome Club and the UPenn Chromatin Biochemistry Group.
Highly motivated applicants with relevant scientific background are encouraged to apply. Please send a CV and a statement of research interests to: blackbe@pennmedicine.upenn.edu
One postdoctoral position is available in the laboratory of Dr. Gerd Blobel at The Children’s Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania (http://www.med.upenn.edu/apps/faculty/index.php/g20000343/p1105). We are an enthusiastic, interactive group of scientists interested in gene regulation, chromatin organization, epigenetics, and hematopoiesis. Lab members are part of a rich training environment that reaches across diverse Departments and includes the Epigenetics Program at U-Penn.
Applicants should be highly motivated, independent, and have a strong background in molecular biology or biochemistry. Candidates with some level of bioinformatics experience analyzing genome-wide data sets will be considered favorably.
Please send CV, a statement of research goals, and contact information of three references to: blobel@email.chop.edu
Description: Our laboratory in the Department of Dermatology at the Perelman School of Medicine at the University of Pennsylvania is seeking to immediately recruit a Postdoctoral Fellow to study epigenetic and epitranscriptomic gene regulatory mechanisms in epithelial cancers and aging. The ideal candidate would have a strong background in bioinformatics and the analysis of a variety of next-generation sequencing data. Experimental techniques utilized range from ChIP-seq, m6A-seq, and single-cell RNA-seq to a variety of molecular and imaging assays utilizing both in vitro and in vivo approaches.
Qualifications: Applicants are required to have an M.D. or Ph.D. in biomedical science or a related field and substantial experience conducting independent research, with at least one first author publication in an internationally recognized, peer-reviewed, science journal. Prior experience in bioinformatics is highly desired. Preference will be given to candidates with in-depth training in research involving next-generation sequencing technologies and bioinformatic analyses.
Contact: Please email a cover letter with a brief statement of your research interests along with your current CV, including bibliography and contact information of 3 references to Brian C. Capell, M.D., Ph.D. at capellb@pennmedicine.upenn.edu. Please include the title Postdoctoral Position in the subject of the e-mail.
The Cremins Lab in the Department of Bioengineering and the Epigenetics Program at the University of Pennsylvania is recruiting up to *three* highly motivated postdoctoral research fellows with expertise in molecular biology and/or genomics. Candidate can begin as early as October 2015.The candidate will be part of an enthusiastic interdisciplinary team focused on analyzing 3-D organization of epigenomes in the developing mammalian central nervous system using genomics technologies and high-throughput sequencing. The laboratory space is located in Penn’s Department of Bioengineering and laboratory members have will have extensive involvement in the Epigenetics Program in Penn’s School of Medicine, thus providing a rich multi-disciplinary training environment in molecular biology, genomics, epigenetics, stem cells, bioinformatics and biostatistics.Candidates are required to hold a PhD, MD, or both. Expertise in cell and/or molecular biology is required, including, but not limited to, cloning, CRISPR/Cas9 genome editing, qRT-PCR, virus packaging, mammalian cell transduction, chromatin immunoprecipitation, chromosome-conformation- capture, etc. Preference will be given to candidates with experience generating data sets for high-throughput sequencing and genomics analysis. Although these positions are for wet-lab experimental scientist(s), opportunities will be abundant to learn computational analysis of genomics data. Candidates with some level of bioinformatics experience analyzing genome-wide epigenetic data sets will be considered favorably.Applicants can submit a CV, a statement of research interests, and 3 or more references to jcremins@seas.upenn.edu.
Post-doctoral positions are available in laboratory of Dr. Kavitha Sarma at the Wistar Institute in Philadelphia. Candidates must be highly motivated, enthusiastic and interactive scientists with interests in gene regulation, chromatin biology and epigenetics. A strong background in molecular biology and protein biochemistry and experience in mammalian cell culture is required. Candidates with experience in RNA-Seq and ChIP-Seq technologies are preferred.
Please send a CV, statement of research and career goals and contact information for 3 references to ksarma@wistar.org.
For more details on research and a list of publications visit:
https://www.wistar.org/our-science/scientists/kavitha-sarma-phd
http://www.ncbi.nlm.nih.gov/pubmed/?term=Kavitha+Sarma
Multiple (5+) postdoctoral positions for wet (experimental), dry (computational), or hybrid biologists are available in the lab of Dr. Golnaz Vahedi at the University of Pennsylvania. The Vahedi lab’s productivity (22 publications in 5 years) has been recognized by prestigious NIH and foundation awards. We are supported by the Burroughs Wellcome Fund, Chan Zuckerberg Initiative, the Sloan Foundation, and the National Institutes of Health including 4D Nucleome and HIRN Consortiums.
We are affiliated with the Department of Genetics, the Epigenetics Institute, and the Institute for Immunology, Perelman School of Medicine at the University of Pennsylvania. The Vahedi lab is multidisciplinary, integrating cutting-edge experimental and computational approaches to develop a mechanistic understanding of cell fate determination in the immune system. Further information about our science could be found at https://vahedilab.com/
Our major contributions to the field include:
(1) Discovery of genome misfolding in type 1 diabetes (https://www.cell.com/immunity/fulltext/S1074-7613(20)30030-3 received major media attention and featured on journal cover)
(2) Discovery of TCF-1 as a pioneer factor in T cells (https://www.cell.com/immunity/fulltext/S1074-7613(18)30033-5 featured on journal cover)
(3) Development of a novel technology for the joint profiling of chromatin accessibility and CAR-T integration site analysis at the single-cell level (https://www.pnas.org/content/early/2020/02/19/1919259117.short)
Experimental candidates are required to hold a PhD in biomedical sciences and track-records in molecular biology, immunology, or biochemistry. Experience with latest genomics and/or imaging technologies will be viewed favorably. Potential training opportunities in computational sciences exist for the experimental trainees.
Computational candidates are required to hold a PhD in computer science, engineering, physics, or related quantitative programs. Expertise with the Unix environment and programing in Python and R are required. Trainees with track-records in machine learning or statistics are encouraged to apply.
Interested applicants should submit a CV to vahedi@pennmedicine.upenn.edu
This listing is also available at: https://www.nature.com/naturecareers/job/postdoctoral-positions-at-the-penn-epigenetics-institute-philadelphia-pa-university-of-pennsylvania-penn-732106
We are seeking to recruit multiple postdoctoral fellows (wet – experimental, dry – computational or hybrid) to work at the intersection of single-cell sequencing, epigenetics, functional genomics and human stem cell biology under the supervision of Dr. Hao Wu (https://www.med.upenn.edu/apps/faculty/index.php/p8878781) in the Department of Genetics at the Perelman School of Medicine at the University of Pennsylvania. These positions are funded by National Human Genome Research Institute (NHGRI, “the Impact of Genomic Variation on Function (IGVF) consortium”) and Chan Zuckerberg Initiative (CZI, “Pediatric Networks for the Human Cell Atlas”).
Our group investigates transcription control and epigenetic regulation by developing high-precision epigenomics (single-nucleotide resolution), single-cell multi-omics (gene expression/chromatin accessibility/DNA methylation) or temporal-omics (metabolic labeling single-cell RNA-seq) methods. Our long-term goal is to use knowledge gained from quantitative and high-precision single-cell genomics technologies to advance our understanding of the impact of genetic variants on gene regulatory networks, lineage specification (cardiac or neural) and human diseases. Our laboratory is part of Penn Epigenetics Institute and Penn Institute of Regenerative Medicine. The University of Pennsylvania provides an outstanding environment for postdoctoral training. Our colleagues include world-class basic scientists and physicians. There are abundant opportunities for collaboration with other groups at Penn, and at other institutions.
Qualifications:
We aspire to create a diverse, stimulating, and collaborative lab environment. Candidates must have a collegial attitude, determination and excellent communication/technical skills.
– A doctoral degree (Ph.D. or M.D.) in the biological science or computational biology.
– At least one first-author publication in peer-reviewed journals.
– The candidate for dry/hybrid lab position is required to be proficient in Linux and programming languages (R or Python). Experience with analysis of next-generation sequencing or single-cell genomics data is preferred but not required.
– The candidate for wet lab position is required to have biochemistry and molecular biology skills. Experience with next generation sequencing is preferred but not required.
If you are interested in our lab, please email a cover letter with a brief description of your research background and interests along with your CV and contact information of three references to Hao Wu, Ph.D. at haowu2@pennmedicine.upenn.edu.
The Zhou laboratory (https://www.med.upenn.edu/apps/faculty/index.php/p8330052) is looking for motivated individuals, either at the level of postdoc or research technician, to join our team to investigate the pathogenic mechanisms underlying multiple neurodevelopmental and neuropsychiatric disorders. If you know of any recently graduated or soon-to-defend graduate students or college seniors, please feel free to forward this message to them. Individuals with experience in neuroscience and bioinformatics will be given a high priority of consideration.
Please email zhaolan@pennmedicine.upenn.edu with any questions or recommendations.
The Zhou laboratory (https://www.med.upenn.edu/apps/faculty/index.php/p8330052) is looking for motivated individuals, either at the level of postdoc or research technician, to join our team to investigate the pathogenic mechanisms underlying multiple neurodevelopmental and neuropsychiatric disorders. If you know of any recently graduated or soon-to-defend graduate students or college seniors, please feel free to forward this message to them. Individuals with experience in neuroscience and bioinformatics will be given a high priority of consideration.
Please email zhaolan@pennmedicine.upenn.edu with any questions or recommendations.
External Positions
Sebastian Baumgarten is starting a new group for RNA biology of malaria parasites at the Institut Pasteur, Paris, in 2021. There are open positions for a PostDoc and PhD student who would like to join. Both positions focus on mRNA modifications and are fully funded through an ERC Starting Grant for an initial period of three years. Sebastian is looking for candidates with a strong background in molecular/RNA biology and/or epigenetics and who like a new challenge. Here are the official job listings:
Job Category: General & Administrative – Ionis
For more than 30 years, Ionis Pharmaceuticals has been the leader in RNA-targeted therapy, pioneering new markets and
changing standards of care with our novel antisense technology. Scientific innovation began and continues at Ionis with the
understanding that sick people depend on us.
As the first company to fully harness the power of RNA technology for human therapeutics, our platform continues to
revolutionize drug discovery and transform the lives of patients with unmet needs. Our medicines span multiple therapeutic
areas, routes of administration and diverse patient populations. Ionis innovation is driving meaningful progress for many of the
most challenging health issues.
We are building upon our innovative research and drug development excellence to provide greater value to patients. Based on
the breadth and remarkable progress of our pipeline, Ionis is projecting to have a vast number of new transformational
products on the market in the coming years and growing our commercial capabilities. We are well positioned financially to
deliver on our strategic goals.
Ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence. Our
success is a direct result of our outstanding employees. We are interested in bringing together a diverse workforce, comprised
of individuals from different backgrounds and with unique skill sets, into our creative and productive environment. Join us and
experience our unique culture while you develop and expand your career.
Job Category: Research – Ionis
For more than 30 years, Ionis Pharmaceuticals has been the leader in RNA-targeted therapy, pioneering new markets and
changing standards of care with our novel antisense technology. Scientific innovation began and continues at Ionis with the
understanding that sick people depend on us.
As the first company to fully harness the power of RNA technology for human therapeutics, our platform continues to
revolutionize drug discovery and transform the lives of patients with unmet needs. Our medicines span multiple therapeutic
areas, routes of administration and diverse patient populations. Ionis innovation is driving meaningful progress for many of the
most challenging health issues.
We are building upon our innovative research and drug development excellence to provide greater value to patients. Based on
the breadth and remarkable progress of our pipeline, Ionis is projecting to have a vast number of new transformational
products on the market in the coming years and growing our commercial capabilities. We are well positioned financially to
deliver on our strategic goals.
Ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence. Our
success is a direct result of our outstanding employees. We are interested in bringing together a diverse workforce, comprised
of individuals from different backgrounds and with unique skill sets, into our creative and productive environment. Join us and
experience our unique culture while you develop and expand your career.
Ionis Pharmaceuticals, Inc., one of the 2020 Best Places to Work in San Diego, is in the North San Diego County city of
Carlsbad. For more than 30 years, Ionis has been the leader in RNA-targeted therapy, pioneering new markets and changing
standards of care with our novel antisense technology. Ionis currently has three marketed medicines – Spinraza, the standard
of care for all forms of spinal muscular atrophy; Tegsedi, the first approved RNA-targeted therapy for polyneuropathy caused
by hereditary ATTR (transthyretin) amyloidosis; and Waylivra, the only approved treatment for familial chylomicronemia
syndrome (FCS). Ionis has a premier late-stage pipeline highlighted by our industry-leading neurological and cardiometabolic
franchises. Scientific innovation began and continues at Ionis with the understanding that sick people depend on the success
of the company. This belief drives Ionis’ vision of becoming one of the most successful biotechnology companies.
As the first company to fully harness the power of RNA technology for human therapeutics, Ionis’ platform continues to
revolutionize drug discovery and transform lives for patients with unmet needs. Ionis’ medicines span multiple therapeutic
areas, routes of administration and diverse patient populations, and Ionis innovation is driving meaningful progress for many
of the most challenging health issues.
Ionis is building upon our innovative research and drug development excellence to provide greater value to patients. Based on
the breadth and remarkable progress of our pipeline, Ionis is projecting to have a vast number of new transformational
products on the market in the coming years. Ionis is well positioned financially to deliver on our strategic goals.
Ionis is a challenging, motivating and rewarding environment designed to foster innovation and scientific excellence. Our
success is a direct result of our outstanding employees. We are interested in bringing together individuals with different skill
sets into this creative environment to be part of a productive team. Join us and experience our unique culture while you
develop and expand your career.