Cancer and Metabolism Epigenetics

The cancer epigenetics and metabolism program provides a forum to nucleate researcher at Penn studying interrelationships between chromatin state and cancer biology. Emerging evidence from this multidisciplinary group reveals that metabolic changes present in cancer cells not only affect energy balance and anabolic processes that support uncontrolled cellular proliferation during cancer, but also impact histone post-translational modifications and chromatin state. We seek to address fundamental questions regarding the mechanisms underlying these chromatin associated phenomena and how they influence transcription, DNA repair, cellular differentiation state, and other cancer phenotypes.

Publications

From Brian Capell Lab

MLL4 MEDIATES DIFFERENTIATION AND TUMORSUPPRESSION THROUGH FERROPTOSIS.
Egolf S, Zou J, Anderson A, Simpson CL, Aubert Y, Prouty S, Ge K, Seykora JT, Capell BC. Sci Adv. 2021 Dec 10;7(50):eabj9141. doi: 10.1126/sciadv.abj9141. Epub 2021 Dec 10. PMID: 34890228; PMCID: PMC8664260.

From Junwei Shi Lab

CONTROLLABLE GENOME EDITING WITH SPLIT-ENGINEERED BASE EDITORS.
Berríos KN, Evitt NH, DeWeerd RA, Ren D, Luo M, Barka A, Wang T, Bartman CR, Lan Y, Green AM, Shi J*, Kohli RM*. Nature Chemical Biology, 2021 Oct (*co-corresponding author).
 

From Junwei Shi Lab

ZMYND8-REGULATED IRF8 TRANSCRIPTION AXIS IS AN ACUTE MYELOID LEUKEMIA DEPENDENCY.

Cao ZBudinich KA, Huang H, Ren D, Lu B, Zhang ZChen Q, Zhou Y, Huang Y-H, Alikarami F, Kingsley M, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi JMolecular Cell, 2021, Jul.

From Junwei Shi Lab

IN VIVO CD8 T CELL CRISPR SCREENING REVEALS CONTROL BY FLI1 IN INFECTION AND CANCER.
Chen Z, Arai E, Khan O, Zhang Z, Ngiow SF, He Y, Huang H, Manne S, Cao Z, Baxter AE, Cai Z, Freilich E, Ali MA, Giles JR, Wu JE, Greenplate AR, Hakeem MA, Chen Q, Kurachi M, Nzingha K, Ekshyyan V, Mathew D, Wen Z, Speck NA, Battle A, Berger SL, Wherry JE*, Shi J*Cell, 2021 Mar (*co-corresponding author).

 
From Kathryn Wellen Lab

QUANTITATIVE SUB-CELLULAR ACYL-COA ANALYSIS REVEALS DISTINCT NUCLEAR METABOLISM AND ISOLEUCINE-DEPENDENT HISTONE PROPIONYLATION.
Trefely S, Huber K, Liu J Noji M, Stransky S, Singh J,  Doan MT,Lovell CD, von Krusenstiern E, Jiang H, Bostwick A, Pepper HL, Izzo L, Zhao Z, Xu JP, Bedi Jr KC, Rame JE,  Bogner-Strauss J, Mesaros C,Sidoli S, Wellen KE*, Snyder NW*. Mol Cell, Jan 20;82(2):447-462    *co-corresponding authors

 

From Roger Greenberg and Junwei Shi Labs

ALC1 LINKS CHROMATIN ACCESSIBILITY TO PARP INHIBITOR RESPONSE IN HOMOLOGOUS RECOMBINATION DEFICIENT CELLS.
Verma P, Zhou Y, Cao Z,  Deraska PV, Deb M, Arai E, Li W, Shao Y, Li Y, Puentes L, Patankar S, Mach RH, Faryabi RB, Shi J*, Greenberg RA*. Nature Cell Biology, 2021 Jan.  (*co-corresponding author)

 

From Junwei Shi Lab

GENETIC SCREENING FOR SINGLE-CELL VARIABILITY MODULATORS DRIVING THERAPY RESISTANCE.
Torre EA, Arai E, Bayatpour S, Beck LE, Emert BL, Shaffer SM, Mellis IA, Fane M, Alicea G, Budinich KA, Weeraratna A, Shi J*, Raj A*. Nature Genetics, 2021 Jan. (*co-corresponding author)

 

 

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