Education

Faculty in the Epigenetics Institute participate in several different PhD programs at the University of Pennsylvania. All of the graduate students in Epigenetics labs enter through one of the graduate groups under the aegis of the Biomedical Graduate Studies or the Biology Program at the School of Arts and Sciences.

Graduate Groups

Biochemistry & Molecular Biophysics

Cell & Molecular Biology

Microbiology, Virology & Parasitology

Epidemiology & Biostatistics

Genomics & Computational Biology

Immunology

Neuroscience

Pharmacology

Courses

David W. Speicher & Benjamin Garcia

BMB 626 (SPRING): MASS SPECTROMETRY AND PROTEOMICS

This course will provide a detailed introduction to proteomics and mass spectrometry. The role of mass spectrometry in both characterizing proteins for traditional protein structure – function studies and identification of proteins in proteome studies will be emphasized. Targeted and global proteomes, quantitative protein profiling and compositional proteomics, and applications of proteome studies will be discussed. Intended for second year graduate students and others with an interest in proteomics or mass spectrometry.


Matthew Weitzman & Michael Betts

CAMB 706 (FALL & SPRING) MVP Core

This is a course for first year CAMB-MVP students that provides fundamental knowledge of Microbiology, Virology, and Parasitology. The course starts with 2 overview lectures and is then organized into three sections that cover key principles, experimental approaches, and seminal findings from research on bacteria, viruses and parasites through lectures, paper presentations and class discussions.


Ronen Marmorstein & Emmanuel Skordalakes

BMB 554 (Fall): Macromolecular Crystallography: Methods and applications

This is an introductory course on methods and applications of macromolecular structure determination using X-ray crystallography


Gerd Blobel

BIOM 555 (Fall & Spring) “REGULATION OF THE GENOME”

My lecture is on “Chromatin Regulation In the context of nuclear architecture”.


Doris Wagner

BIOL/CAMB 483 (Fall): Epigenetics

The course aims to introduce students to the field of epigenetics – phenomena that can for example give rise heritable alternate states of gene activity that do not result from an alteration in nucleotide composition (mutations) – through a combination of lectures,  guest research and methods presentations, as well as discussion of recent findings published in this field.


Jennifer E. Phillips Cremins

BE504: Biological Data Science II – Data Mining Principles for Epigenomics (Spring)

This course will teach upper level undergraduates and graduate students how to answer biological questions by harnessing the wealth of genomic and epigenomic data sets generated by high-throughput sequencing technologies. Fundamentals in biostatistics, computational biology, chromatin biology and epigenetics will be taught through a series of case studies focused on cutting edge biological questions in biomedical research.


Jennifer E. Phillips-Cremins

ENM375: Biological Data Science I – Fundamentals of Biostatistics (Spring)

The goal of this course is to equip students with fundamental concepts in applied probability, exploratory data analysis and statistical inference. Students will learn statistical principles in the context of solving biomedical research problems.


Zhaolan (Joe) Zhou

BIOM555 (Spring): Regulation of the Genome

This is a lecture based survey course covering topics from genome maintenance, gene transcription, chromatin structure, to high-order chromatin regulation, as well as topics of post-transcriptional regulation, of which each topic is lectured by a local leader in that specific field.


Arjun Raj

BE/GCB567 (Fall)

This course provides an introduction to mathematical modeling in molecular systems biology, with an emphasis on simulations, scientific programming and probability.


Shelley Berger

BIOL / CAMB / GCB493 (Spring): Epigenetics of Human Health and Disease

Epigenetic alterations encompass heritable, non-genetic changes to chromatin (the polymer of DNA plus histone proteins) that influence cellular and organismal processes. This course will examine epigenetic mechanisms in directing development from the earliest stages of growth, and in maintaining normal cellular homeostasis during life. We will also explore how diverse epigenetic processes are at the heart of numerous human disease states. We will review topics ranging from an historical perspective of the discovery of epigenetic mechanisms to the use of modern technology and drug development to target epigenetic mechanisms to increase healthy lifespan and combat human disease. The course will involve a combination of didactic lectures, primary scientific literature and research lectures, and student-led presentations.