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Cardiomyocyte Microtubules: Control of Mechanics, Transport, and Remodeling.

Cardiomyocyte Microtubules: Control of Mechanics, Transport, and Remodeling. 

Uchida K, Scarborough EA, Prosser BL.

Annu Rev Physiol. 2022 Feb 10;84:257-283. doi: 10.1146/annurev-physiol-062421-040656. Epub 2021 Oct 6. PMID: 34614374
Heart Failure RNA Biology Mechanobiology

Need for Speed: The Importance of Physiological Strain Rates in Determining Myocardial Stiffness. 

Need for Speed: The Importance of Physiological Strain Rates in Determining Myocardial Stiffness. 

Caporizzo MA, Prosser BL.

Front Physiol. 2021 Jul 30;12:696694. doi: 10.3389/fphys.2021.696694. eCollection 2021. PMID: 34393820
Heart Failure Mechanobiology

X-ROS Signaling Depends on Length-Dependent Calcium Buffering by Troponin. 

X-ROS Signaling Depends on Length-Dependent Calcium Buffering by Troponin. 

Limbu S, Prosser BL, Lederer WJ, Ward CW, Jafri MS.

Cells. 2021 May 13;10(5):1189. doi: 10.3390/cells10051189. PMID: 34068012
Mechanobiology

Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing. 

Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing. 

Chen T, Rohacek AM, Caporizzo M, Nankali A, Smits JJ, Oostrik J, Lanting CP, Kücük E, Gilissen C, van de Kamp JM, Pennings RJE, Rakowiecki SM, Kaestner KH, Ohlemiller KK, Oghalai JS, Kremer H, Prosser BL, Epstein DJ.

Dev Cell. 2021 May 17;56(10):1526-1540.e7. doi: 10.1016/j.devcel.2021.04.017. Epub 2021 May 7. PMID: 33964205
Mechanobiology

Microtubules orchestrate local translation to enable cardiac growth. 

Microtubules orchestrate local translation to enable cardiac growth. 

Scarborough EA, Uchida K, Vogel M, Erlitzki N, Iyer M, Phyo SA, Bogush A, Kehat I, Prosser BL.

Nat Commun. 2021 Mar 11;12(1):1547. doi: 10.1038/s41467-021-21685-4.

PMID: 33707436

RNA Biology Mechanobiology

Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. 

Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes. 

Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R.

Cell Stem Cell. 2021 May 6;28(5):938-954.e9. doi: 10.1016/j.stem.2020.12.016. Epub 2021 Feb 1. PMID: 33529599
Mechanobiology

Tubulin Detyrosination: An Emerging Therapeutic Target in Hypertrophic Cardiomyopathy. 

Tubulin Detyrosination: An Emerging Therapeutic Target in Hypertrophic Cardiomyopathy. 

Margulies KB, Prosser BL.

Circ Heart Fail. 2021 Jan;14(1):e008006. doi: 10.1161/CIRCHEARTFAILURE.120.008006. Epub 2021 Jan 12. PMID: 33430601
Heart Failure Mechanobiology

Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes.

Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes. 

Chen CY, Salomon AK, Caporizzo MA, Curry S, Kelly NA, Bedi K, Bogush AI, Krämer E, Schlossarek S, Janiak P, Moutin MJ, Carrier L, Margulies KB, Prosser BL.

Circ Res. 2020 Jul 3;127(2):e14-e27. doi: 10.1161/CIRCRESAHA.119.315947. Epub 2020 Apr 10. PMID: 32272864
Heart Failure Mechanobiology

Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium. 

Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium. 

Caporizzo MA, Chen CY, Bedi K, Margulies KB, Prosser BL.

Circulation. 2020 Mar 17;141(11):902-915. doi: 10.1161/CIRCULATIONAHA.119.043930. Epub 2020 Jan 16. PMID: 31941365
Heart Failure Mechanobiology

A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte. 

A Balance Between Intermediate Filaments and Microtubules Maintains Nuclear Architecture in the Cardiomyocyte. 

Heffler J, Shah PP, Robison P, Phyo S, Veliz K, Uchida K, Bogush A, Rhoades J, Jain R, Prosser BL.

Circ Res. 2020 Jan 31;126(3):e10-e26. doi: 10.1161/CIRCRESAHA.119.315582. Epub 2019 Dec 11. PMID: 31822208

Cardiac microtubules in health and heart disease. 

Cardiac microtubules in health and heart disease. 

Caporizzo MA, Chen CY, Prosser BL.

Exp Biol Med. 2019 Nov;244(15):1255-1272. doi: 10.1177/1535370219868960. Epub 2019 Aug 9. PMID: 31398994  Review.
Heart Failure RNA Biology Mechanobiology

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest. 

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest. 

Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang HY, Greenberg RA, Prosser BL, Discher DE.

Dev Cell. 2019 Jun 17;49(6):920-935.e5. doi: 10.1016/j.devcel.2019.04.020. Epub 2019 May 16. PMID: 31105008
Mechanobiology

Microtubules Provide a Viscoelastic Resistance to Myocyte Motion. 

Microtubules Provide a Viscoelastic Resistance to Myocyte Motion. 

Caporizzo MA, Chen CY, Salomon AK, Margulies KB, Prosser BL.

Biophys J. 2018 Nov 6;115(9):1796-1807. doi: 10.1016/j.bpj.2018.09.019. Epub 2018 Sep 28. PMID: 30322798
Mechanobiology

Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure. 

Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure. 

Chen CY, Caporizzo MA, Bedi K, Vite A, Bogush AI, Robison P, Heffler JG, Salomon AK, Kelly NA, Babu A, Morley MP, Margulies KB, Prosser BL.

Nat Med. 2018 Aug;24(8):1225-1233. doi: 10.1038/s41591-018-0046-2. Epub 2018 Jun 11. PMID: 29892068
Heart Failure Mechanobiology

MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress. 

MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress. 

Nemani N, Carvalho E, Tomar D, Dong Z, Ketschek A, Breves SL, Jaña F, Worth AM, Heffler J, Palaniappan P, Tripathi A, Subbiah R, Riitano MF, Seelam A, Manfred T, Itoh K, Meng S, Sesaki H, Craigen WJ, Rajan S, Shanmughapriya S, Caplan J, Prosser BL, Gill DL, Stathopulos PB, Gallo G, Chan DC, Mishra P, Madesh M.

Cell Rep. 2018 Apr 24;23(4):1005-1019. doi: 10.1016/j.celrep.2018.03.098.

PMID: 29694881

Deregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin. 

Deregulated Ca2+ cycling underlies the development of arrhythmia and heart disease due to mutant obscurin. 

Hu LR, Ackermann MA, Hecker PA, Prosser BL, King B, O’Connell KA, Grogan A, Meyer LC, Berndsen CE, Wright NT, Jonathan Lederer W, Kontrogianni-Konstantopoulos A.

Sci Adv. 2017 Jun 7;3(6):e1603081. doi: 10.1126/sciadv.1603081. eCollection 2017 Jun. PMID: 28630914
Heart Failure

Microtubule mechanics in the working myocyte. 

Microtubule mechanics in the working myocyte. 

Robison P, Prosser BL.

J Physiol. 2017 Jun 15;595(12):3931-3937. doi: 10.1113/JP273046. Epub 2017 Mar 9.PMID: 28116814. Review.
Heart Failure Mechanobiology

Mechanical signaling coordinates the embryonic heartbeat. 

Mechanical signaling coordinates the embryonic heartbeat. 

Chiou KK, Rocks JW, Chen CY, Cho S, Merkus KE, Rajaratnam A, Robison P, Tewari M, Vogel K, Majkut SF, Prosser BL, Discher DE, Liu AJ.

Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):8939-44. doi: 10.1073/pnas.1520428113. Epub 2016 Jul 25. PMID: 27457951
Mechanobiology

Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes. 

Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes. 

Robison P, Caporizzo MA, Ahmadzadeh H, Bogush AI, Chen CY, Margulies KB, Shenoy VB, Prosser BL.

Science. 2016 Apr 22;352(6284):aaf0659. doi: 10.1126/science.aaf0659.

PMID: 27102488

Heart Failure Mechanobiology

Modeling Local X-ROS and Calcium Signaling in the Heart. 

Modeling Local X-ROS and Calcium Signaling in the Heart. 

Limbu S, Hoang-Trong TM, Prosser BL, Lederer WJ, Jafri MS.

Biophys J. 2015 Nov 17;109(10):2037-50. doi: 10.1016/j.bpj.2015.09.031. PMID: 26588563
Mechanobiology

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle. 

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle. 

Kerr JP, Robison P, Shi G, Bogush AI, Kempema AM, Hexum JK, Becerra N, Harki DA, Martin SS, Raiteri R, Prosser BL, Ward CW.

Nat Commun. 2015 Oct 8;6:8526. doi: 10.1038/ncomms9526. PMID: 26446751
Heart Failure Mechanobiology

Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation. 

Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation. 

Zhang M, Prosser BL, Bamboye MA, Gondim ANS, Santos CX, Martin D, Ghigo A, Perino A, Brewer AC, Ward CW, Hirsch E, Lederer WJ, Shah AM.

J Am Coll Cardiol. 2015 Jul 21;66(3):261-272. doi: 10.1016/j.jacc.2015.05.020.

PMID: 26184620

Heart Failure Mechanobiology

Myosin-binding protein C corrects an intrinsic inhomogeneity in cardiac excitation-contraction coupling. 

Myosin-binding protein C corrects an intrinsic inhomogeneity in cardiac excitation-contraction coupling. 

Previs MJ, Prosser BL, Mun JY, Previs SB, Gulick J, Lee K, Robbins J, Craig R, Lederer WJ, Warshaw DM.

Sci Adv. 2015;1(1):e1400205. doi: 10.1126/sciadv.1400205. PMID: 25839057
Heart Failure Mechanobiology

Mechano-chemo transduction tunes the heartstrings. 

Mechano-chemo transduction tunes the heartstrings. 

Prosser BL, Ward CW.

Sci Signal. 2014 Mar 18;7(317):pe7. doi: 10.1126/scisignal.2005214.

PMID: 24643798

Mechanobiology

Mechanical stretch-induced activation of ROS/RNS signaling in striated muscle. 

Mechanical stretch-induced activation of ROS/RNS signaling in striated muscle. 

Ward CW, Prosser BL, Lederer WJ.

Antioxid Redox Signal. 2014 Feb 20;20(6):929-36. doi: 10.1089/ars.2013.5517. Epub 2014 Jan 3. PMID: 23971496
Mechanobiology

X-ROS signalling is enhanced and graded by cyclic cardiomyocyte stretch. 

X-ROS signalling is enhanced and graded by cyclic cardiomyocyte stretch. 

Prosser BL, Ward CW, Lederer WJ.

Cardiovasc Res. 2013 May 1;98(2):307-14. doi: 10.1093/cvr/cvt066. Epub 2013 Mar 21. PMID: 23524301
Mechanobiology

X-ROS signaling in the heart and skeletal muscle: stretch-dependent local ROS regulates [Ca²⁺]i. 

X-ROS signaling in the heart and skeletal muscle: stretch-dependent local ROS regulates [Ca²⁺]i. 

Prosser BL, Khairallah RJ, Ziman AP, Ward CW, Lederer WJ.

J Mol Cell Cardiol. 2013 May;58:172-81. doi: 10.1016/j.yjmcc.2012.11.011. Epub 2012 Dec 6. PMID: 23220288
Mechanobiology

Microtubules underlie dysfunction in duchenne muscular dystrophy. 

Microtubules underlie dysfunction in duchenne muscular dystrophy. 

Khairallah RJ, Shi G, Sbrana F, Prosser BL, Borroto C, Mazaitis MJ, Hoffman EP, Mahurkar A, Sachs F, Sun Y, Chen YW, Raiteri R, Lederer WJ, Dorsey SG, Ward CW.

Sci Signal. 2012 Aug 7;5(236):ra56. doi: 10.1126/scisignal.2002829.

PMID: 22871609

Mechanobiology

X-ROS signaling: rapid mechano-chemo transduction in heart. 

X-ROS signaling: rapid mechano-chemo transduction in heart. 

Prosser BL, Ward CW, Lederer WJ.

Science. 2011 Sep 9;333(6048):1440-5. doi: 10.1126/science.1202768. PMID: 21903813
Heart Failure Mechanobiology

S100A1 and calmodulin regulation of ryanodine receptor in striated muscle. 

S100A1 and calmodulin regulation of ryanodine receptor in striated muscle. 

Prosser BL, Hernández-Ochoa EO, Schneider MF.

Cell Calcium. 2011 Oct;50(4):323-31. doi: 10.1016/j.ceca.2011.06.001. Epub 2011 Jul 23. PMID: 21784520. Review.

Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1. 

Modulation of sarcoplasmic reticulum Ca2+ release in skeletal muscle expressing ryanodine receptor impaired in regulation by calmodulin and S100A1. 

Yamaguchi N, Prosser BL, Ghassemi F, Xu L, Pasek DA, Eu JP, Hernández-Ochoa EO, Cannon BR, Wilder PT, Lovering RM, Weber D, Melzer W, Schneider MF, Meissner G.

Am J Physiol Cell Physiol. 2011 May;300(5):C998-C1012. doi: 10.1152/ajpcell.00370.2010. Epub 2011 Feb 2. PMID: 21289290

S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle. 

S100A1 promotes action potential-initiated calcium release flux and force production in skeletal muscle. 

Prosser BL, Hernández-Ochoa EO, Lovering RM, Andronache Z, Zimmer DB, Melzer W, Schneider MF.

Am J Physiol Cell Physiol. 2010 Nov;299(5):C891-902. doi: 10.1152/ajpcell.00180.2010. Epub 2010 Aug 4. PMID: 20686070

Subcellular Ca2+ signaling in the heart: the role of ryanodine receptor sensitivity. 

Subcellular Ca2+ signaling in the heart: the role of ryanodine receptor sensitivity. 

Prosser BL, Ward CW, Lederer WJ.

J Gen Physiol. 2010 Aug;136(2):135-42. doi: 10.1085/jgp.201010406.

PMID: 20660656

Augmentation of Cav1 channel current and action potential duration after uptake of S100A1 in sympathetic ganglion neurons. 

Augmentation of Cav1 channel current and action potential duration after uptake of S100A1 in sympathetic ganglion neurons. 

Hernández-Ochoa EO, Prosser BL, Wright NT, Contreras M, Weber DJ, Schneider MF.

Am J Physiol Cell Physiol. 2009 Oct;297(4):C955-70. doi: 10.1152/ajpcell.00140.2009. Epub 2009 Aug 5. PMID: 19657060

Simultaneous recording of intramembrane charge movement components and calcium release in wild-type and S100A1-/- muscle fibres.

Simultaneous recording of intramembrane charge movement components and calcium release in wild-type and S100A1-/- muscle fibres. 

Prosser BL, Hernández-Ochoa EO, Zimmer DB, Schneider MF.

J Physiol. 2009 Sep 15;587(Pt 18):4543-59. doi: 10.1113/jphysiol.2009.177246. Epub 2009 Aug 3. PMID: 19651766

S100A1 and calmodulin compete for the same binding site on ryanodine receptor.

S100A1 and calmodulin compete for the same binding site on ryanodine receptor. 

Wright NT, Prosser BL, Varney KM, Zimmer DB, Schneider MF, Weber DJ.

J Biol Chem. 2008 Sep 26;283(39):26676-83. doi: 10.1074/jbc.M804432200. Epub 2008 Jul 23. PMID: 18650434

S100A1 binds to the calmodulin-binding site of ryanodine receptor and modulates skeletal muscle excitation-contraction coupling. 

S100A1 binds to the calmodulin-binding site of ryanodine receptor and modulates skeletal muscle excitation-contraction coupling. 

Prosser BL, Wright NT, Hernãndez-Ochoa EO, Varney KM, Liu Y, Olojo RO, Zimmer DB, Weber DJ, Schneider MF.

J Biol Chem. 2008 Feb 22;283(8):5046-57. doi: 10.1074/jbc.M709231200. Epub 2007 Dec 17. PMID: 18089560

Truncated titin proteins in dilated cardiomyopathy.

Truncated titin proteins in dilated cardiomyopathy.

McAfee Q, Chen CY, Yang Y, Caporizzo MA, Morley M, Babu A, Jeong S, Brandimarto J, Bedi KC Jr, Flam E, Cesare J, Cappola TP, Margulies K, Prosser B, Arany Z.

Sci Transl Med. 2021 Nov 3;13(618):eabd7287. doi: 10.1126/scitranslmed.abd7287. Epub 2021 Nov 3.PMID: 34731015
Heart Failure

Assessing the landscape of STXBP1-related disorders in 534 individuals

Assessing the landscape of STXBP1-related disorders in 534 individuals

Julie Xian,  Shridhar Parthasarathy,  Sarah McKeown,  Ganna Balagura,  Eryn Fitch, Katherine Helbig,  Jing Gan,  Shiva Ganesan,  Michael C Kaufman,  Colin A Ellis, David Lewis-Smith,  Peter Galer,  Kristin Cunningham,  Margaret O’Brien,  Mahgenn Cosico, Kate Baker,  Alejandra Darling,  Fernanda Veiga de Goes,  Christelle M El Achkar, Jan Henje Doering,  Francesca Furia,  Ángeles García-Cazorla,  Elena Gardella, Lisa Geertjens,  Courtney Klein,  Anna Kolesnik-Taylor,  Hanna Lammertse,  Jeehun Lee, Alexandra Mackie,  Mala Misra-Isrie,  Heather Olson,  Emma Sexton,  Beth Sheidley, Lacey Smith,  Luiza Sotero,  Hannah Stamberger,  Steffen Syrbe,  Kim Marie Thalwitzer, Annemiek van Berkel,  Mieke van Haelst,  Christopher Yuskaitis,  Sarah Weckhuysen, Ben Prosser,  Charlene Son Rigby,  Scott Demarest,  Samuel Pierce,  Yuehua Zhang, Rikke Steensbjerre Møller,  Hilgo Bruining,  Annapurna Poduri,  Federico Zara, Matthijs Verhage,  Pasquale Striano,  Ingo Helbig

Brain. 23 November 2021 https://doi.org/10.1093/brain/awab327

Neurodevelopmental Disorders