Integrated Stress Response Potentiates Ponatinib-Induced Cardiotoxicity.
Yan G, Han Z, Kwon Y, Jousma J, Nukala SB, Prosser BL, Du X, Pinho S, Ong SB, Lee WH, Ong SG.
Pietsch N, Chen CY, Kupsch S, Bacmeister L, Geertz B, Herera-Rivero M, Voß H, Krämer E, Braren I, Westermann D, Schlüter H, Mearini G, Schlossarek S, van der Velden J, Caporizzo MA, Lindner D, Prosser BL, Carrier L.
McAfee Q, Caporizzo MA, Uchida K, Bedi KC, Margulies KB, Arany Z, Prosser BL.
Pinpointing the contributors to myocardial passive stiffness.
Benjamin L. Prosser.
Adult human cardiomyocyte mechanics in osteogenesis imperfecta
BW, Caporizzo MA, Chen CY, Bedi KC Jr, Peyster EG, Prosser BL, Margulies KB, Vite A.
An unbiased screen identified the Hsp70-BAG3 complex as a regulator of myosin binding protein C3
Andrea D. Thompson, Marcus J. Wagner, Juliani Rodriguez, Alok Malhotra, Steve Vander Roest, Ulla Lilienthal, Hao Shao, Mathav Vignesh, Keely Weber, Jaime M. Yob, Benjamin L. Prosser, Adam S. Helms, Jason E. Gestwicki, David Ginsburg, Sharlene M. Day.
Early life seizures and epileptic spasms in STXBP1 -related disorders.
Thalwitzer KM, Xian J, deCampo D, Parthasarathy S, Magielski J, Sullivan KR, Goss J, Rigby CS, Boland M, Prosser B, Ruggiero SM, Syrbe S, Helbig I.
Delineating clinical and developmental outcomes in STXBP1-related disorders.
Xian J, Thalwitzer KM, McKee J, Sullivan KR, Brimble E, Fitch E, Toib J, Kaufman MC, deCampo D, Cunningham K, Pierce SR, Goss J, Son Rigby C, Syrbe S, Boland M, Prosser B, Fitter N, Ruggiero SM, Helbig I.
Dawicki-McKenna JM, Felix AJ, Waxman EA, Cheng C, Amado DA, Ranum PT, Bogush A, Dungan LV, Maguire JA, Gagne AL, Heller EA, French DL, Davidson BL, Prosser BL.
Marco Luciani, Mauro Montalbano, Luca Troncone, Camilla Bacchin, Keita Uchida, Gianlorenzo Daniele, Bethany Jacobs Wolf, Helen M Butler, Justin Kiel, Stefano Berto, Cortney Gensemer, Kelsey Moore, Jordan Morningstar, Thamonwan Diteepeng, Onder Albayram, José F Abisambra, Russell A Norris, Thomas G Di Salvo, Benjamin Prosser, Rakez Kayed, Federica del Monte
Salomon AK, Phyo SA, Okami N, Heffler J, Robison P, Bogush AI, Prosser BL.
Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy.
Flam E, Jang C, Murashige D, Yang Y, Morley MP, Jung S, Kantner DS, Pepper H, Bedi KC Jr, Brandimarto J, Prosser BL, Cappola T, Snyder NW, Rabinowitz JD, Margulies KB, Arany Z.
Vite A, Caporizzo MA, Corbin EA, Brandimarto J, McAfee Q, Livingston CE, Prosser BL, Margulies KB.
The microtubule cytoskeleton in cardiac mechanics and heart failure.
Caporizzo MA, Prosser BL.
Assessing the landscape of STXBP1-related disorders in 534 individuals.
Xian J, Parthasarathy S, Ruggiero SM, Balagura G, Fitch E, Helbig K, Gan J, Ganesan S, Kaufman MC, Ellis CA, Lewis-Smith D, Galer P, Cunningham K, O’Brien M, Cosico M, Baker K, Darling A, Veiga de Goes F, El Achkar CM, Doering JH, Furia F, García-Cazorla Á, Gardella E, Geertjens L, Klein C, Kolesnik-Taylor A, Lammertse H, Lee J, Mackie A, Misra-Isrie M, Olson H, Sexton E, Sheidley B, Smith L, Sotero L, Stamberger H, Syrbe S, Thalwitzer KM, van Berkel A, van Haelst M, Yuskaitis C, Weckhuysen S, Prosser B, Son Rigby C, Demarest S, Pierce S, Zhang Y, Møller RS, Bruining H, Poduri A, Zara F, Verhage M, Striano P, Helbig I.
Base editing the synapse: Modeling a complex neurological disorder in non-human primates.
Prosser BL, Helbig I.
Phyo SA, Uchida K, Chen CY, Caporizzo MA, Bedi K, Griffin J, Margulies K, Prosser BL.
Truncated titin proteins in dilated cardiomyopathy.
McAfee Q, Chen CY, Yang Y, Caporizzo MA, Morley M, Babu A, Jeong S, Brandimarto J, Bedi KC Jr, Flam E, Cesare J, Cappola TP, Margulies K, Prosser B, Arany Z.
Cardiomyocyte Microtubules: Control of Mechanics, Transport, and Remodeling.
Uchida K, Scarborough EA, Prosser BL.
Need for Speed: The Importance of Physiological Strain Rates in Determining Myocardial Stiffness.
Caporizzo MA, Prosser BL.
X-ROS Signaling Depends on Length-Dependent Calcium Buffering by Troponin.
Limbu S, Prosser BL, Lederer WJ, Ward CW, Jafri MS.
Cochlear supporting cells require GAS2 for cytoskeletal architecture and hearing.
Chen T, Rohacek AM, Caporizzo M, Nankali A, Smits JJ, Oostrik J, Lanting CP, Kücük E, Gilissen C, van de Kamp JM, Pennings RJE, Rakowiecki SM, Kaestner KH, Ohlemiller KK, Oghalai JS, Kremer H, Prosser BL, Epstein DJ.
Microtubules orchestrate local translation to enable cardiac growth.
Scarborough EA, Uchida K, Vogel M, Erlitzki N, Iyer M, Phyo SA, Bogush A, Kehat I, Prosser BL.
Nat Commun. 2021 Mar 11;12(1):1547. doi: 10.1038/s41467-021-21685-4.
PMID: 33707436
Shah PP, Lv W, Rhoades JH, Poleshko A, Abbey D, Caporizzo MA, Linares-Saldana R, Heffler JG, Sayed N, Thomas D, Wang Q, Stanton LJ, Bedi K, Morley MP, Cappola TP, Owens AT, Margulies KB, Frank DB, Wu JC, Rader DJ, Yang W, Prosser BL, Musunuru K, Jain R.
Tubulin Detyrosination: An Emerging Therapeutic Target in Hypertrophic Cardiomyopathy.
Margulies KB, Prosser BL.
Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes.
Chen CY, Salomon AK, Caporizzo MA, Curry S, Kelly NA, Bedi K, Bogush AI, Krämer E, Schlossarek S, Janiak P, Moutin MJ, Carrier L, Margulies KB, Prosser BL.
Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium.
Caporizzo MA, Chen CY, Bedi K, Margulies KB, Prosser BL.
Heffler J, Shah PP, Robison P, Phyo S, Veliz K, Uchida K, Bogush A, Rhoades J, Jain R, Prosser BL.
Cardiac microtubules in health and heart disease.
Caporizzo MA, Chen CY, Prosser BL.
Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest.
Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang HY, Greenberg RA, Prosser BL, Discher DE.
Microtubules Provide a Viscoelastic Resistance to Myocyte Motion.
Caporizzo MA, Chen CY, Salomon AK, Margulies KB, Prosser BL.
Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure.
Chen CY, Caporizzo MA, Bedi K, Vite A, Bogush AI, Robison P, Heffler JG, Salomon AK, Kelly NA, Babu A, Morley MP, Margulies KB, Prosser BL.
MIRO-1 Determines Mitochondrial Shape Transition upon GPCR Activation and Ca2+ Stress.
Nemani N, Carvalho E, Tomar D, Dong Z, Ketschek A, Breves SL, Jaña F, Worth AM, Heffler J, Palaniappan P, Tripathi A, Subbiah R, Riitano MF, Seelam A, Manfred T, Itoh K, Meng S, Sesaki H, Craigen WJ, Rajan S, Shanmughapriya S, Caplan J, Prosser BL, Gill DL, Stathopulos PB, Gallo G, Chan DC, Mishra P, Madesh M.
Cell Rep. 2018 Apr 24;23(4):1005-1019. doi: 10.1016/j.celrep.2018.03.098. PMID: 29694881
Microtubule mechanics in the working myocyte.
Robison P, Prosser BL.
Hu LR, Ackermann MA, Hecker PA, Prosser BL, King B, O’Connell KA, Grogan A, Meyer LC, Berndsen CE, Wright NT, Jonathan Lederer W, Kontrogianni-Konstantopoulos A.
Mechanical signaling coordinates the embryonic heartbeat.
Chiou KK, Rocks JW, Chen CY, Cho S, Merkus KE, Rajaratnam A, Robison P, Tewari M, Vogel K, Majkut SF, Prosser BL, Discher DE, Liu AJ.
Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes.
Robison P, Caporizzo MA, Ahmadzadeh H, Bogush AI, Chen CY, Margulies KB, Shenoy VB, Prosser BL.
Science. 2016 Apr 22;352(6284):aaf0659. doi: 10.1126/science.aaf0659.
PMID: 27102488
Modeling Local X-ROS and Calcium Signaling in the Heart.
Limbu S, Hoang-Trong TM, Prosser BL, Lederer WJ, Jafri MS.
Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle.
Kerr JP, Robison P, Shi G, Bogush AI, Kempema AM, Hexum JK, Becerra N, Harki DA, Martin SS, Raiteri R, Prosser BL, Ward CW.
Zhang M, Prosser BL, Bamboye MA, Gondim ANS, Santos CX, Martin D, Ghigo A, Perino A, Brewer AC, Ward CW, Hirsch E, Lederer WJ, Shah AM.
J Am Coll Cardiol. 2015 Jul 21;66(3):261-272. doi: 10.1016/j.jacc.2015.05.020.
PMID: 26184620
Previs MJ, Prosser BL, Mun JY, Previs SB, Gulick J, Lee K, Robbins J, Craig R, Lederer WJ, Warshaw DM.
Mechano-chemo transduction tunes the heartstrings.
Prosser BL, Ward CW.
Sci Signal. 2014 Mar 18;7(317):pe7. doi: 10.1126/scisignal.2005214.
PMID: 24643798
Mechanical stretch-induced activation of ROS/RNS signaling in striated muscle.
Ward CW, Prosser BL, Lederer WJ.
Mathias Hohl 1 , Hossein Ardehali, Francisco J Azuaje, Ross A Breckenridge, Wolfram Doehner, Philip Eaton, Georg B Ehret, Toshiro Fujita, Roberto Gaetani, Mauro Giacca, Gerd Hasenfuß, Stephane Heymans, Adelino F Leite-Moreira, Wolfgang A Linke, Dominik Linz, Alexander Lyon, Mamas A Mamas, Matej Orešič, Zoltán Papp, Thierry Pedrazzini, Massimo Piepoli, Benjamin Prosser, Rosario Rizzuto, Guido Tarone, Rong Tian, Emeline van Craenenbroeck, Eva van Rooij, Timothy Wai, Günter Weiss, Christoph Maack
X-ROS signalling is enhanced and graded by cyclic cardiomyocyte stretch.
Prosser BL, Ward CW, Lederer WJ.
X-ROS signaling in the heart and skeletal muscle: stretch-dependent local ROS regulates [Ca²⁺]i.
Prosser BL, Khairallah RJ, Ziman AP, Ward CW, Lederer WJ.
Microtubules underlie dysfunction in duchenne muscular dystrophy.
Khairallah RJ, Shi G, Sbrana F, Prosser BL, Borroto C, Mazaitis MJ, Hoffman EP, Mahurkar A, Sachs F, Sun Y, Chen YW, Raiteri R, Lederer WJ, Dorsey SG, Ward CW.
Sci Signal. 2012 Aug 7;5(236):ra56. doi: 10.1126/scisignal.2002829.
PMID: 22871609
X-ROS signaling: rapid mechano-chemo transduction in heart.
Prosser BL, Ward CW, Lederer WJ.
S100A1 and calmodulin regulation of ryanodine receptor in striated muscle.
Prosser BL, Hernández-Ochoa EO, Schneider MF.
Yamaguchi N, Prosser BL, Ghassemi F, Xu L, Pasek DA, Eu JP, Hernández-Ochoa EO, Cannon BR, Wilder PT, Lovering RM, Weber D, Melzer W, Schneider MF, Meissner G.
Lovering RM, O’Neill A, Muriel JM, Prosser BL, Strong J, Bloch RJ.
Prosser BL, Hernández-Ochoa EO, Lovering RM, Andronache Z, Zimmer DB, Melzer W, Schneider MF.
Subcellular Ca2+ signaling in the heart: the role of ryanodine receptor sensitivity.
Prosser BL, Ward CW, Lederer WJ.
J Gen Physiol. 2010 Aug;136(2):135-42. doi: 10.1085/jgp.201010406. PMID: 20660656
Hernández-Ochoa EO, Prosser BL, Wright NT, Contreras M, Weber DJ, Schneider MF.
Prosser BL, Hernández-Ochoa EO, Zimmer DB, Schneider MF.
Prosser BL, Hernández-Ochoa EO, Zimmer DB, Schneider MF.
S100A1 and calmodulin compete for the same binding site on ryanodine receptor.
Wright NT, Prosser BL, Varney KM, Zimmer DB, Schneider MF, Weber DJ.
Prosser BL, Wright NT, Hernãndez-Ochoa EO, Varney KM, Liu Y, Olojo RO, Zimmer DB, Weber DJ, Schneider MF.