Welcome To Black Lab.

The Black Lab is answering the most pressing questions in chromosome biology, such as:

  • How does genetic inheritance actually work?
  • How was epigenetic information transmitted to us from our parents?
  • Can building new artificial chromosomes help us understand how natural chromosomes work?
  • How are the key enzymes protecting the integrity of our genome specifically and potently activated by potential catastrophes like DNA breaks or chromosome misattachment to the mitotic spindle?


Levani’s HXMS findings reveal key insight about the activation and inhibition of PARP-1 in a collaborative study with implications for how to best target PARP-1 in certain forms of cancer

Lucie leads study describing a 270 kDa centromeric nucleosome complex that maintains centromere identity

Jennine co-leads a collaborative study providing evidence that amplified centromeric DNA repeats act as selfish genetic elements in female meiosis

Ben edits a 22 chapter book on Centromeres and Kinetochores with contributions from our colleagues from 9 countries/4 continents

Scientific Community

We are very active in scientific interactions across several departments, programs, and schools here at UPenn, including close-knit ties to graduate programs in Biochemistry and Molecular Biophysics (BMB) and Cell and Molecular Biology (CAMB). We are also co-founders of multi-lab group meetings of the Philly Chromosome Club.