Welcome To Black Lab.

The Black Lab is answering the most pressing questions in chromosome biology, such as:

  • How does genetic inheritance actually work?
  • How was epigenetic information transmitted to us from our parents?
  • Can building new artificial chromosomes help us understand how natural chromosomes work?
  • How are the key enzymes protecting the integrity of our genome specifically and potently activated by potential catastrophes like DNA breaks or chromosome misattachment to the mitotic spindle?

News

Glennis and Craig develop a new type of human artificial chromosome that removes a key barrier limiting mammalian synthetic genome efforts, reported in our paper in Cell and highlighted here, here, and here

Praveen leads cryo-EM study of core centromeric chromatin complex, developing a new model for kinetochore assembly at the onset of mitosis

Craig publishes an essay on centromere identity in a special issue on DNA packaging: Nucleosome and Chromatin

Levani’s HXMS findings reveal key insight about the activation and inhibition of PARP-1 in a collaborative study with implications for how to best target PARP-1 in certain forms of cancer

 

Scientific Community

We are very active in scientific interactions across several departments, programs, and schools here at UPenn, including close-knit ties to graduate programs in Biochemistry and Molecular Biophysics (BMB) and Cell and Molecular Biology (CAMB). We are also co-founders of multi-lab group meetings of the Philly Chromosome Club.