The Penn Epigenetics Institute announces a request for applications of a Pilot Project Grant for faculty to conduct Epigenetics-related research projects. A broad spectrum of proposal topics will be considered. Including those that involve fundamental studies in Epigenetics as well as more applied or disease-oriented studies that utilize Epigenetics as a central component of the research.

Award Amount & Duration: Up to $50,000 for a 1-year pilot project. Renewable for a second year of funding.

Award Dates:
Application Receipt Deadline: May 2, 2022, at 11:59 pm
Notification of Award: June 6, 2022
Funding Period: July 1, 2022 – June 30, 2023

Apply Here:


2023 At-Large Epi Pilot Grant RFA



Past At-Large Epigenetics Pilot Grant Awardees

Year(s) AwardedInvestigator(s)Title of ProjectPublication(s)Grant Submission(s)
2023George Burslem, Ph.D. & Andrey Poleshko, Ph.D.Unbiased Probe Discover for Epigenetics ReprogrammingN/AN/A
2023Wanding Zhou, Ph.D., 8 Rahul Kohli, M.D., Ph.D. & Marisa Bartolomei, Ph.D.Comprehensive resolution of epigenome diversity using the ternary-code DNA modificationN/AN/A
2023Erica Korb, Ph.D. & George Burslem, Ph.D.Developing tools to examine the role and regulation of histone crotonylation in the brainN/AN/A
2020Brian Capell, M.D., Ph.D & Kathy Fange Liu, Ph.D.Defining the m6A epitranscriptome in epithelial gene regulaLon, development, and carcinogenesisN/AN/A
2020Roberto Bonasio, Ph.D. & Elizabeth Heller, Ph.D.In search of the epigeneQc engram in planariansN/AN/A
2019 & 2020Elizabeth Heller, Ph.D. & Zhaolan Zhou, Ph.D.Application of a novel method for neuronal cell-type specific simultaneous transcriptome and epigenome profiling in vivo in miceN/AN/A
2019 & 2020Junwei Shi, Ph.D.Develop a Cas 12a-based genetic method to identify paired epigenetic dependencies in acute myeloid leukemiaN/AN/A
2018 & 2019Eric Joyce, Ph.D., Melike Lakadamyali, Ph.D. & Rajan Jain, M.D.Inheritance of Lamin-associated domains and their role in maintaining cellular identityN/AN/A
2018 & 2019Maya Capelson, Ph.D. & Eric Joyce, Ph.D.Identifying regulators of nuclear gene positioning via a high-throughput imaging screen.Alejandro Gozalo, Ashley Duke, Yemin Lan, Pau Pascual-Garcia, Jessica A. Talamas, Son Nguyen, Eric F. Joyce and Maya Capelson. Core components of the nuclear pore bind distinct states of chromatin and contribute to Polycomb repression. In review at Mol CellN/A
2017 & 2018Hao Wu, Ph.D. & Rahul M. Kohli, M.D., Ph.D.APOBEC-Coupled Epigenetic SequencingEK Schutsky, JE DeNizio, P Hu, MY Liu, CS Nabel, EB Fabyanic, Y Hwang, FD Bushman, H Wu, RM Kohli, Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase. Nature Biotechnology, accepted on 24 May 2018.N/A
2017 & 2018Golnaz Vahedi, Ph.D. & Nancy A. Speck, Ph.DUncovering regulatory coordination during T cell development using single-cell epigenomicsN/ASubmitted to NIDDK in May 2018
2015 & 2017Benjamin Garcia, Ph.D.A novel mass spectrometry based platform for characterization of microRNA (miRNA) post-transcriptional modificationsN/AN/A
2015 & 2017Robert Babak Faryabi, Ph.D. & Warren S. Pear, M.D., Ph.D.Interrogating the oncogenic enhancer landscape in B cell lymphomaNotch-Regulated Enhancers in B-Cell Lymphoma Activate MYC and Potentiate B-Cell Receptor Signaling. Russell JH Ryan, Jelena Petrovic, Dylan Rausch, Caleb Lareau, Winston Lee, Laura Donohue, Amanda L Christie, Shawn Gillespie, Michael J Kluk, Valentina Nardi, Robert B Faryabi, Ephraim P Hochberg, David M Weinstock, Bradley E Bernstein, Jon C Aster, Warren S Pear. Blood Dec 2016.1) Targeting the Notch:Myc axis in leukemia/lymphoma, NCI R01. Scored at 12th percentile (Nov 2016), current NCI payline is 10th percentile. 2) Oncogenic Notch Signaling P01 (submitted September 2016)
2015Arjun Raj, Ph.D. & Roberto Bonasio, Ph.D.CRISPR Drop-seqN/AN/A
2013 & 2014Ben Black, Ph.D. & Michael Lampson, Ph.D.Maintaining centromere identity in mammalian oocytesN/AN/A
2013 & 2014Hua-Ying Fan, Ph.D.Mechanisms of Transcription Memory Maintenance by the Notch Pathway Effector RBPJRBPJ, the major transcriptional effector of Notch signaling, remains associated with chromatin throughout mitosis, suggesting a role in mitotic bookmarking. Lake RJ, Tsai PF, Choi I, Won KJ, Fan HY. PLoS Genet. 2014 Mar 6;10(3):e1004204. doi: 10.1371/journal.pgen.1004204. eCollection 2014 Mar. Erratum in: PLoS Genet. 2016 Jul;12(7):e1006209. PMID:24603501NIH/NIGMS 1R01GM114132-01 Title: Mechanistic basis for mitotic transcriptional memory
2013 & 2014Maya Capelson, Ph.D. & Sara Cherry, Ph.D.Defining Role of Nuclear Pore Proteins in Antiviral Gene ExpressionNup98 promotes antiviral gene expression to restrict RNA viral infection in Drosophila. Panda D, Pascual-Garcia P, Dunagin M, Tudor M, Hopkins KC, Xu J, Gold B, Raj A, Capelson M, Cherry S.Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):E3890-9. doi: 10.1073/pnas.1410087111. Epub 2014 Sep 2. PMID:25197089N/A