Timothe Maujean, Prakash Kannaboina, Adam I Green, and George Burslem. Lead-Oriented Synthesis of Epigenetic Relevant Scaffolds. Chemical Communications. 15 Nov 2023. https://doi.org/10.1039/D3CC04317G
Abstract
A simple and rationale method to rank molecules’ lead-likeness using continuous evaluation functions was hereby developed. This strategy proved to be competitive against known methods and finally helped driving synthetic efforts towards candidates of interest for epigenetic applications towards HDAC6, BRD4 and EZH2