Penn Epigenetics Institute Pilot Grant Application Announcement

2020 Epigenetics Pilot Grant Annoucement

At-Large Pilot Project Grant

The Penn Epigenetics Institute announces a request for applications of a Pilot Project Grant for faculty to conduct Epigenetics-related research projects. A broad spectrum of proposal topics will be considered. Including those that involve fundamental studies in Epigenetics as well as more applied or disease-oriented studies that utilize Epigenetics as a central component of the research.

Award Amount & Duration: Up to $50,000 for a 1-year pilot project.  Renewable for the second year of funding.

Award Dates:

  • Application Receipt Deadline: October 25, 2019, at 11:59 pm
  • Notification of Award: November 15, 2019
  • Funding Period: November 25, 2019 – November 25, 2020

2020 At-Large Epi Pilot Grant RFA

Submit Application

  • Past At-Large Epigenetics Pilot Grant Awardees

      Year Awarded
      2020

      Investigator(s)
      Roberto Bonasio, Ph.D. & Elizabeth Heller, Ph.D.

      Title of Project
      In search of the epigenetic engram in planarians

      Year Awarded
      2020

      Investigator(s)
      Brian Capell, M.D., Ph.D. & Kathy Fange Liu, Ph.D.

      Title of Project
      Defining the m6A epitranscriptome in epithelial gene regulation, development and carcinogenesis

      Years Awarded
      2019 & 2020

      Investigator(s)
      Elizabeth Heller, Ph.D. & Zhaolan Zhou, Ph.D.

      Title of Project
      Application of a novel method for neuronal cell-type specific simultaneous transcriptome and epigenome profiling in vivo in mice

      Years Awarded
      2019 & 2020

      Investigator(s)
      Junwei Shi, Ph.D.

      Title of Project
      Develop a Cas 12a-based genetic method to identify paired epigenetic dependencies in acute myeloid leukemia

      Years Awarded
      2018 & 2019

      Investigator(s)
      Eric Joyce, Ph.D., Melike Lakadamyali, Ph.D. & Rajan Jain, M.D.

      Title of Project
      Inheritance of Lamin-associated domains and their role in maintaining cellular identity

      Years Awarded
      2018 & 2019

      Investigator(s)
      Maya Capelson, Ph.D. & Eric Joyce, Ph.D.

      Title of Project
      Identifying regulators of nuclear gene positioning via a high-throughput imaging screen.

      Publications
      Alejandro Gozalo, Ashley Duke, Yemin Lan, Pau Pascual-Garcia, Jessica A. Talamas, Son Nguyen, Eric F. Joyce and Maya Capelson. Core components of the nuclear pore bind distinct states of chromatin and contribute to Polycomb repression.  In review at Mol Cell

      Years Awarded
      2017 & 2018

      Investigator(s)
      Hao Wu, Ph.D. & Rahul M. Kohli, M.D., Ph.D.

      Title of Project
      APOBEC-Coupled Epigenetic Sequencing

      Publications
      EK Schutsky, JE DeNizio, P Hu, MY Liu, CS Nabel, EB Fabyanic, Y Hwang, FD Bushman, H Wu, RM Kohli, Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase. Nature Biotechnology, accepted on 24 May 2018.

      Years Awarded
      2017 & 2018

      Investigator(s)
      Golnaz Vahedi, Ph.D. & Nancy A. Speck, Ph.D.

      Title of Project
      Uncovering regulatory coordination during T cell development using single-cell epigenomics

      Grant Submissions
      Submitted to NIDDK in May 2018

      Years Awarded
      2015 & 2017

      Investigator(s)
      Benjamin Garcia, Ph.D.

      Title of Project
      A novel mass spectrometry based platform for characterization of microRNA (miRNA) post-transcriptional modifications

      Years Awarded
      2015 & 2017

      Investigator(s)
      Robert Babak Faryabi, Ph.D. & Warren S. Pear, M.D., Ph.D.

      Title of Project
      Interrogating the oncogenic enhancer landscape in B cell lymphoma

      Publications
      Notch-Regulated Enhancers in B-Cell Lymphoma Activate MYC and Potentiate B-Cell Receptor Signaling. Russell JH Ryan, Jelena Petrovic, Dylan Rausch, Caleb Lareau, Winston Lee, Laura Donohue, Amanda L Christie, Shawn Gillespie, Michael J Kluk, Valentina Nardi, Robert B Faryabi, Ephraim P Hochberg, David M Weinstock, Bradley E Bernstein, Jon C Aster, Warren S Pear. Blood Dec 2016.

      Grant Submissions
      1)  Targeting the Notch:Myc axis in leukemia/lymphoma, NCI R01. Scored at 12th percentile (Nov 2016), current NCI payline is 10th percentile.

      2) Oncogenic Notch Signaling P01 (submitted September 2016)

      Year Awarded
      2015

      Investigator(s)
      Arjun Raj, Ph.D. & Roberto Bonasio, Ph.D.

      Title of Project
      CRISPR Drop-seq

      Years Awarded
      2013 & 2014

      Investigator(s)
      Hua-Ying Fan, Ph.D.

      Title of Project
      Mechanisms of Transcription Memory Maintenance by the Notch Pathway Effector RBPJ

      Publications
      RBPJ, the major transcriptional effector of Notch signaling, remains associated with chromatin throughout mitosis, suggesting a role in mitotic bookmarking. Lake RJ, Tsai PF, Choi I, Won KJ, Fan HY. PLoS Genet. 2014 Mar 6;10(3):e1004204. doi: 10.1371/journal.pgen.1004204. eCollection 2014 Mar. Erratum in: PLoS Genet. 2016 Jul;12(7):e1006209. PMID:24603501

      Grant Submissions
      NIH/NIGMS 1R01GM114132-01
      Title: Mechanistic basis for mitotic transcriptional memory

      Year Awarded
      2013 & 2014

      Investigator(s)
      Ben Black, Ph.D. & Michael Lampson, Ph.D.

      Title of Project
      Maintaining centromere identity in mammalian oocytes

       

      Year Awarded
      2013 & 2014

      Investigator(s)
      Maya Capelson, Ph.D. & Sara Cherry, Ph.D.

      Title of Project
      Defining Role of Nuclear Pore Proteins in Antiviral Gene Expression

      Publications
      Nup98 promotes antiviral gene expression to restrict RNA viral infection in Drosophila.
      Panda D, Pascual-Garcia P, Dunagin M, Tudor M, Hopkins KC, Xu J, Gold B, Raj A, Capelson M, Cherry S.Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):E3890-9. doi: 10.1073/pnas.1410087111. Epub 2014 Sep 2. PMID:25197089

Mass Spectrometry & Epigenetics Pilot Project Grant

The Penn Epigenetics Institute announces a request for applications of a Pilot Project Grant for faculty to conduct epigenetics-related research projects involving the use of mass spectrometry. A broad spectrum of proposal topics will be considered, including those that involve fundamental studies in epigenetics as well as more applied or disease-oriented studies that utilize mass spectrometry as a central component of the research.

Award Amount & Duration: Up to $30,000 for a 1-year pilot project.

Award Dates:

  • Application Receipt Deadline: October 25, 2019, at 11:59 pm
  • Notification of Award: November 15, 2019
  • Funding Period: November 25, 2019 – November 25, 2020

2020 Mass Spectrometry & Epigenetics Pilot Grant RFA

Submit Application

  • Past Mass Spectrometry & Epigenetics Pilot Grant Awardees

      Year Awarded
      2020

      Investigator(s)
      Erica Korb, Ph.D.

      Title of Project
      Unique Properties of Histone Variant Proteins in the Brain

      Year Awarded
      2019

      Investigator(s)
      Roger Greenberg, M.D., Ph.D. & Luca Busino, Ph.D.

      Title of Project
      Determine protein degradation at the Chromatin Double Strand Breaks

      Year Awarded
      2018

      Investigator(s)
      Kathryn Wellen, Ph.D.

      Title of Project
      Diet and epigenetic regulation of liver metabolism

      Year Awarded
      2017

      Investigator(s)
      Sarah E. Millar, Ph.D.

      Title of Project
      Identification of non-histone targets of Class I histone deacetylases in embryonic and adult epidermis and basal cell carcinoma

      Publications
      Zhu X, Leboeuf M, Liu F, Chen S, Olson EN, Morrisey EE, Dlugosz AA, Millar, SE. (2018). HDAC1 and HDAC2 regulate homeostasis and tumorigenesis of postnatal epidermis. Journal of Investigative Dermatology 138, S28

Chemical/Genetic Screening Epigenetics Institute Pilot Grant Program

The Epigenetics Institute at Penn in collaboration with the High-throughput Screening Core (HTSC) at Penn is announcing a Pilot Grant Program to utilize the expertise and services of the core available to members of the Epigenetics community.  The specific scientific focus of this pilot grant application is non-restrictive, but applications must utilize the services of the HTSC.  Applications with a focus to utilize the cores’ ability to screen either a) FDA approved drugs and known bioactives library or b) siRNA libraries of Gene Ontology (GO) categories or user defined gene sets to identify/validate candidate gene targets are encouraged.  In preparing a proposal, applicants are encouraged to consult with the core directors about the feasibility of a candidate screen, e.g. reporter gene assay, and budget.  Importantly, pilot grants that are responsive to an upcoming RFA, future NIH Concept or other future funding mechanisms will be given priority. The science remains a priority; however, it is important to emphasize how results from utilizing the core’s services will be used to leverage additional funding to support an expanded study.

High-throughput screening core: The Penn High-throughput screening core (HTSC) provides the PSOM community with technical expertise in HTS to identify genes or organic small molecule inhibitors of signaling pathways and cellular phenotypes in models of human disease.  To meet the needs of investigators, the HTS provides advice and assistance with assay developing biological assays (i.e. biochemical-, cell-, and high-content) in miniaturized, multiwell microtiter plates that are laboratory automation compatible for HTS. For a consultation contact David C. Schultz, PhD, Technical Director (dschultz@pennmedicine.upenn.edu).

Award Amount & Duration: Up to $20,000 for a 1-year pilot project.

Award Dates:

  • Application Receipt Deadline: October 25, 2019, at 11:59 pm
  • Notification of Award: November 15, 2019
  • Funding Period: November 25, 2019 – November 25, 2020

2020 Chemical_Genetic Screening Epigenetics Pilot RFA

Submit Application

  • Past Chemical / Genetic Screening Epigenetics Institute Pilot Grant Awardees

      Year Awarded
      2019

      Investigator(s)
      Irfan A. Asangani, Ph.D.

      Title of Project
      High throughput screening of FDA approved drugs with EZH2 inhibitor in prostate cancer cells

      Year Awarded
      2017

      Investigator(s)
      Irfan A. Asangani, Ph.D.

      Title of Project
      High throughput screening of FDA approved drugs with EZH2 inhibitor in prostate cancer cells