Penn Epigenetics Institute Pilot Grant Application Annoucement

At-Large Pilot Project Grant

The Penn Epigenetics Institute announces a request for applications of a Pilot Project Grant for faculty to conduct epigenetics-related research projects. A broad spectrum of proposal topics will be considered, including those that involve fundamental studies in epigenetics as well as more applied or disease-oriented studies that utilize epigenetics as a central component of the research.

Award Amount & Duration: Up to $50,000 for a 1-year pilot project.  Renewable for the second year of funding.

Award Dates:

  • Application Receipt Deadline: October 12, 2018, at 11:59 pm
  • Notification of Award: November 9, 2018
  • Funding Period: November 12, 2018 – November 11, 2019

2019 At-Large Epi Pilot Grant RFA

Submit Application

  • Past At-Large Epigenetics Pilot Grant Awardees

      Year Awarded
      2019 (2nd Year)

      Investigator(s)
      Eric Joyce, Ph.D., Melike Lakadamyali, Ph.D. & Rajan Jain, M.D.

      Title of Project
      Inheritance of Lamin-associated domains and their role in maintaining cellular identity

      Year Awarded
      2019 (2nd Year)

      Investigator(s)
      Maya Capelson, Ph.D. & Eric Joyce, Ph.D.

      Title of Project
      Identifying regulators of nuclear gene positioning via a high-throughput imaging screen.

      Year Awarded
      2019

      Investigator(s)
      Elizabeth Heller, Ph.D. & Zhaolan Zhou, Ph.D.

      Title of Project
      Application of a novel method for neuronal cell-type specific simultaneous transcriptome and epigenome profiling in vivo in mice

      Year Awarded
      2019

      Investigator(s)
      Junwei Shi, Ph.D.

      Title of Project
      Develop a Cas 12a-based genetic method to identify paired epigenetic dependencies in acute myeloid leukemia

      Year Awarded
      2018 (2nd Year)

      Investigator(s)
      Hao Wu, Ph.D. & Rahul M. Kohli, M.D., Ph.D.

      Title of Project
      APOBEC-Coupled Epigenetic Sequencing

      Year Awarded
      2018 (2nd Year)

      Investigator(s)
      Golnaz Vahedi, Ph.D. & Nancy A. Speck, Ph.D.

      Title of Project
      Uncovering regulatory coordination during T cell development using single-cell epigenomics

      Grant Submissions
      Submitted to NIDDK in May 2018

      Year Awarded
      2018

      Investigator(s)
      Maya Capelson, Ph.D. & Eric Joyce, Ph.D.

      Title of Project
      Identifying regulators of nuclear gene positioning via a high-throughput imaging screen.

      Publications
      Alejandro Gozalo, Ashley Duke, Yemin Lan, Pau Pascual-Garcia, Jessica A. Talamas, Son Nguyen, Eric F. Joyce and Maya Capelson. Core components of the nuclear pore bind distinct states of chromatin and contribute to Polycomb repression.  In review at Mol Cell

      Year Awarded
      2018

      Investigator(s)
      Eric Joyce, Ph.D., Melike Lakadamyali, Ph.D & Rajan Jain, M.D.

      Title of Project
      Inheritance of Lamin-associated domains and their role in maintaining cellular identity

      Year Awarded
      2017

      Investigator(s)
      Golnaz Vahedi, Ph.D. & Nancy A. Speck, Ph.D.

      Title of Project
      Uncovering regulatory coordination during T cell development using single-cell epigenomics

      Year Awarded
      2017

      Investigator(s)
      Hao Wu, Ph.D. & Rahul M. Kohli, M.D., Ph.D.

      Title of Project
      APOBEC-Coupled Epigenetic Sequencing

      Publications
      EK Schutsky, JE DeNizio, P Hu, MY Liu, CS Nabel, EB Fabyanic, Y Hwang, FD Bushman, H Wu, RM Kohli, APOBEC-Coupled Epigenetic Sequencing permits low-input, bisulfate free localization of 5-hydroxymethylcytosine at base resolution. Nature Biotechnology, accepted on 24 May 2018.

      Year Awarded
      2017 (2nd Year)

      Investigator(s)
      Benjamin Garcia, Ph.D.

      Title of Project
      A novel mass spectrometry based platform for characterization of microRNA (miRNA) post-transcriptional modifications

      Year Awarded
      2017 (2nd Year)

      Investigator(s)
      Robert Babak Faryabi, Ph.D. & Warren S. Pear, M.D., Ph.D.

      Title of Project
      Interrogating the oncogenic enhancer landscape in B cell lymphoma

      Year Awarded
      2015

      Investigator(s)
      Benjamin Garcia, Ph.D.

      Title of Project
      A novel mass spectrometry based platform for characterization of microRNA (miRNA) post-transcriptional modifications

      Year Awarded
      2015

      Investigator(s)
      Robert Babak Faryabi, Ph.D. & Warren S. Pear, M.D., Ph.D.

      Title of Project
      Interrogating the oncogenic enhancer landscape in B cell lymphoma

      Publications
      Notch-Regulated Enhancers in B-Cell Lymphoma Activate MYC and Potentiate B-Cell Receptor Signaling. Russell JH Ryan, Jelena Petrovic, Dylan Rausch, Caleb Lareau, Winston Lee, Laura Donohue, Amanda L Christie, Shawn Gillespie, Michael J Kluk, Valentina Nardi, Robert B Faryabi, Ephraim P Hochberg, David M Weinstock, Bradley E Bernstein, Jon C Aster, Warren S Pear. Blood Dec 2016.

      Grant Submissions
      1)  Targeting the Notch:Myc axis in leukemia/lymphoma, NCI R01. Scored at 12th percentile (Nov 2016), current NCI payline is 10th percentile.

      2) Oncogenic Notch Signaling P01 (submitted September 2016)

      Year Awarded
      2015

      Investigator(s)
      Arjun Raj, Ph.D. & Roberto Bonasio, Ph.D.

      Title of Project
      CRISPR Drop-seq

      Year Awarded
      2014 (2nd year)

      Investigator(s)
      Hua-Ying Fan, Ph.D.rjun Raj, Ph.D. & Roberto Bonasio, Ph.D.

      Title of Project
      Mechanisms of Transcription Memory Maintenance by the Notch Pathway Effector RBPJ

      Year Awarded
      2014 (2nd year)

      Investigator(s)
      Ben Black, Ph.D. & Michael Lampson, Ph.D.

      Title of Project
      Maintaining centromere identity in mammalian oocytes

      Year Awarded
      2014 (2nd year)

      Investigator(s)
      Maya Capelson, Ph.D. & Sara Cherry, Ph.D.

      Title of Project
      Defining Role of Nuclear Pore Proteins in Antiviral Gene Expression

      Year Awarded
      2013

      Investigator(s)
      Hua-Ying Fan, Ph.D.

      Title of Project
      Mechanisms of Transcription Memory Maintenance by the Notch Pathway Effector RBPJ

      Publications
      RBPJ, the major transcriptional effector of Notch signaling, remains associated with chromatin throughout mitosis, suggesting a role in mitotic bookmarking. Lake RJ, Tsai PF, Choi I, Won KJ, Fan HY. PLoS Genet. 2014 Mar 6;10(3):e1004204. doi: 10.1371/journal.pgen.1004204. eCollection 2014 Mar. Erratum in: PLoS Genet. 2016 Jul;12(7):e1006209. PMID:24603501

      Grant Submissions
      NIH/NIGMS 1R01GM114132-01
      Title: Mechanistic basis for mitotic transcriptional memory

      Year Awarded
      2013

      Investigator(s)
      Ben Black, Ph.D. & Michael Lampson, Ph.D.

      Title of Project
      Maintaining centromere identity in mammalian oocytes

      Publications
      Nup98 promotes antiviral gene expression to restrict RNA viral infection in Drosophila.
      Panda D, Pascual-Garcia P, Dunagin M, Tudor M, Hopkins KC, Xu J, Gold B, Raj A, Capelson M, Cherry S.Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):E3890-9. doi: 10.1073/pnas.1410087111. Epub 2014 Sep 2. PMID:25197089

      Year Awarded
      2013

      Investigator(s)
      Maya Capelson, Ph.D. & Sara Cherry, Ph.D.

      Title of Project
      Defining Role of Nuclear Pore Proteins in Antiviral Gene Expression

Mass Spectrometry & Epigenetics Pilot Project Grant

The Penn Epigenetics Institute announces a request for applications of a Pilot Project Grant for faculty to conduct epigenetics-related research projects involving the use of mass spectrometry. A broad spectrum of proposal topics will be considered, including those that involve fundamental studies in epigenetics as well as more applied or disease-oriented studies that utilize mass spectrometry as a central component of the research.

Award Amount & Duration: Up to $30,000 for a 1-year pilot project.

Award Dates:

  • Application Receipt Deadline: October 12, 2018, at 11:59 pm
  • Notification of Award: November 9, 2018
  • Funding Period: November 12, 2018 – November 11, 2019

2019 Mass Spectrometry & Epigenetics Pilot Grant RFA

Submit Application

  • Past Mass Spectrometry & Epigenetics Pilot Grant Awardees

      Year Awarded
      2019

      Investigator(s)
      Roger Greenberg, M.D., Ph.D. & Luca Busino, Ph.D.

      Title of Project
      Determine protein degradation at the Chromatin Double Strand Breaks

      Year Awarded
      2018

      Investigator(s)
      Kathryn Wellen, Ph.D.

      Title of Project
      Diet and epigenetic regulation of liver metabolism

      Year Awarded
      2017

      Investigator(s)
      Sarah E. Millar, Ph.D.

      Title of Project
      Identification of non-histone targets of Class I histone deacetylases in embryonic and adult epidermis and basal cell carcinoma

      Publications
      Zhu X, Leboeuf M, Liu F, Chen S, Olson EN, Morrisey EE, Dlugosz AA, Millar, SE. (2018). HDAC1 and HDAC2 regulate homeostasis and tumorigenesis of postnatal epidermis. Journal of Investigative Dermatology 138, S28

Chemical/Genetic Screening Epigenetics Institute Pilot Grant Program

The Epigenetics Institute at Penn in collaboration with the High-throughput Screening Core (HTSC) at Penn is announcing a Pilot Grant Program to highlight the expertise and services of the core available to members of the Epigenetics community.  The specific scientific focus of 2019 pilot grant applications is non-restrictive, but applications must utilize the services of the HTSC.  Applications with a focus to utilize the cores’ ability to screen either a) FDA approveddrug and known bioactives library or b) siRNA libraries of Gene Ontology (GO) categories or user defined gene sets to identify/validate candidate gene targets are encouraged. In preparing proposal, applicants are encouraged to consult with the core directors about the feasibility of a candidate screen, e.g. reporter gene assay, and budget.  Importantly, pilot grants that are responsive to an upcoming RFA, future NIH Concept or other future funding mechanisms will be given priority.The science remains a priority; however, it is important to emphasize how results from utilizing the core’s services will be used to leverage additional funding to support an expanded study.

High-throughput screening core: The Penn High-throughput screening core (HTSC) provides the PSOM community with HTS resources to identify genes or organic small molecule inhibitors of signaling pathways and cellular phenotypes in models of human disease.  To meet the needs of investigators, the HTS provides consultation and assistance with assay development and high-throughput screening of chemical and genetic libraries. For a consultation contact David C. Schultz, PhD, Technical Director (dschultz@pennmedicine.upenn.edu)

Award Amount & Duration: Up to $20,000 for a 1-year pilot project.  Renewable for the second year of funding.

Award Dates:

  • Application Receipt Deadline: October 12, 2018, at 11:59 pm
  • Notification of Award: November 9, 2018
  • Funding Period: November 12, 2018 – November 11, 2019

2019 Chemical_Genetic Screening Epigenetics Pilot RFA

Submit Application

  • Past Chemical / Genetic Screening Epigenetics Institute Pilot Grant Awardees

      Year Awarded
      2019 (2nd Year)

      Investigator(s)
      Irfan A. Asangani, Ph.D.

      Title of Project
      High throughput screening of FDA approved drugs with EZH2 inhibitor in prostate cancer cells

      Year Awarded
      2017

      Investigator(s)
      Irfan A. Asangani, Ph.D.

      Title of Project
      High throughput screening of FDA approved drugs with EZH2 inhibitor in prostate cancer cells